Molecular and Functional Imaging
Head of Core Facility
Methodologies for in-vivo magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) of human, animal and plant tissues with spatial resolution reaching to 0.1 mm, with the main application in functional (fMRI) and molecular imaging (mMRI) of the brain.
Basic as well as applied research in medicine (human and animal) including pharmacology, molecular and cell biology requires in-vivo insight into live organs and tissues as a very important part of a multi-level and multidisciplinary approach. Modern MRI methods make it possible to visualise the anatomical structures of living objects, but also to discover their functional organisation and the chemical mechanisms underlying health and disease. Currently an effort is put in tracking their dynamics, to multimodal imaging (such as by combining MR with electrophysiology or transcranial magnetic stimulation), and to visualise biological processes at the cellular and molecular levels using molecular MRI by employing targeted contrast agents, spectroscopic imaging, diffusometry or relaxometry. The intended infrastructure will be also used for technological and methodological research aiming to improve existing imaging methods or to develop new methods and data processing strategies for the study of animate as well as inanimate matter, thus establishing a bridge between life and material sciences.
Key Equipment (Core Facility fully operational from 2014)
- Head human 7T MR scanner
- Whole-body human 3T MR scanner
- Multichannel head RF coil for 7T MR
- MR compatible EEG system
- MR compatible stimulation system
All CEITEC core facilities are available to external users (academia and companies). Czech and international researchers from universities and research institutes interested in accessing core facilities can benefit from support of CEITEC – open access project funded by the Ministry of Education, Youth and Sports of the Czech Republic.