Education

• 1979 – Ph.D. (CSc.)  Brno University of Technology (Electrical and Electronic Technology)
• 1975 – M.S. (Ing.)  Brno University of Technology (Control Engineering, Measurement)

Academic Position

• 1998 – Full Professor
• 1985 – 1998   Associate Professor
• 1975 – 1985  Assistant Professor

Faculty member in Undergraduate and Graduate Program in Electrical, Electronic, Communication and Control Technology,  Education in Design of Electronic Circuits and Devices, Electronic Measuring Instruments for Microelectronics, Microelectronic and Optoelectronic Sensors, Programmable Logic Devices, Conversion of Analogue and Digital Signals, more than 80 Diploma students (31 of them with excellent classification), 25 research undergraduate students with published research papers, 14 PhD students.

Research interests 

Electronic systems, smart measurement systems, new types of integrated DA and AD converters, methods of their testing, analysis, simulation, smart industrial and special sensors, processing of sensor signals, networks of intelligent sensors for distributed applications, industrial and automotive communication buses, embedded systems, ASICs. Last few years focused to new embedded ASIC integrated measurement system for control responses from TFT sensors, behavioral and architectural specifications in embedded control system designs, security and safety frameworks, carbon nanotubes synthesized by plasma enhanced CVD for exploiting their electrical properties for application in pressure sensors, composite materials for electromagnetic interference shielding,  smart sensors in wireless network system, artificial neural network for sensors data recognition, wireless communication in automation, executable specifications for embedded distributed systems.

Publications and research outputs

1 monographs, 10 textbooks, over 80 journal and conference full text papers, 6 patents, 5 computer programs, 7 prototypes,  3 utility models; WoS citations 18 (autocitations excluded), h-index: 3

Management experience

13 years (1980/92) Deputy Head of Dept. of Microelectronics, 5 years (1993/97)  Head of Dept. of Microelectronics FEEC BUT (approx. 40 employees).  In 1997, he established and become a CEO (19971999) of MoellerElectric (100% Daughter Company of Klöckner-Moeller International Company seated in Bonn (about 20 employees), yearly turnover of about 10 mil Euro. In 1999, he returned to BUT FEEC as a fullprofessor and in 2000 he started as a ViceDean of FEEC BUT responsible for research and PhD study programmes, and in 2001 he was appointed as the Dean of the BUT FEEC (up to now, approx. 400 academic and supporting technical and administrative staff, more than 4300 students, yearly budget about 16 mil. Euro. Principal investigator of many national and international grants, yearly budget in average 1.5 mil. Euro including two successive long term Research Programs funded by the Ministry of Education, Youth and Sport of the Czech Republic. He has long and deep professional activities with industry in direct cooperation and common research projects (e.g. Megatron, Motorola, Flextronics, Honeywell, AMI  Semiconductors, ON Semiconductor, Knobel, BetaControl, BD Sensors).

Further university and academic service

• Group of experts to evaluate research and development proposals, Ministry of Industry and Trade of the Czech Republic (2001 –  )
• Member of Research and Development Advisory Board for ministerial program TIP (since 2008)
• Member of Scientific Boards: Brno University of Technology (since  2001), Faculty of Electrical Engineering and Communication BUT (since 1995), Faculty of Information Technologies BUT (since 2001), Institute of Scientific Instruments Academy of Sciences Brno (2003  2006).
• Member of  Doctoral Study Boards: Electrical and Electronic Technology;  State examination commissions on undergraduate or doctoral levelchairman: education in Microelectronics and Technology, Microelectronics
• Vice President of A.M.S.E. Association for the Advancement of Modelling  and Simulation Techniques in Enterprises, France (1994 – 2005)
• Member of Editorial Board of Sensors & Transducers Journal (since 1999)

Faculty development

In 1997, he established and became a CEO (19971999) of Moeller-Electric industrial and development company; 1989 Institute of Scientific Instruments, Academy of Science of the Czech Republic – 1 year visiting researcher; 1982 University of Salford, Great Britain – 3 months research fellow.

Running research projects (mostly research team leader and principal investigator)

• E3CAR Nanoelectronics for an Energy Efficient Electrical Car, ENIAC European Project funded by EC and Czech Ministry of Education, 2009 to 2012
• VAN Virtual Automation Networks, European Project funded by EC, 2005 to 2009
• Research and development of digitally tuned of ICs working in mix mode, project GA102/09/1628 funded by Czech Science Foundation, 2009 to 2011
• Methods of signal digitizing for smart sensors, project GA102/08/1116 funded Czech Science Foundation, 2008 to 2010
• KAAPS Research of universal and complex autentization and authorization for permanent and mobile computer networks, project 2C08002 funded by Czech Ministry of Education, 2008 to 2011
• Inteligent platform for wireless communication, project FIIM4/034 of  collaborative research with industrial company Microrisc, Ltd. cofunded by Czech Ministry of Industry and Trade, 2007 to 2010
• Multifunctional composites of extra properties based on inorganic nanocomponents, project FT-TA3/027 of collaborative research with industrial company VUSTAH, a.s. co-funded by Czech Ministry of Industry and Trade, 2006 to 2010
• New trends in microelectronic systems and nanotechnologies, long term project MSM0021630503 funded by Czech Ministry of Education, 2005 to 2011
• Research of new MEMS mechatronic structures applicable for pressure measurement, project 2A1TP1/143 of collaborative research with industrial company BD SENSORS Ltd. Co-funded by Czech Ministry of Industry and Trade, 2005 to 2011

Selected publications

• VRBA, R., VEČEŘA, I. An algorithmic A/D switchedcurrent  converter for smart signal digitization with self-test features.  MEASUREMENT, Journal of the International Measurement Confederation (IMEKO).  2004. 35(2). p. 153 – 160. ISSN 0263-2241. (IF=0,451, IF(2007)=0,5).
• VRBA, R., ŠVÉDA, M. Integrated Smart Sensor Networking Framework for Sensor-Based Appliances.  IEEE SENSORS JOURNAL.  2003. 3(5). p. 579 – 586. ISSN 1530-437X. (IF(2007)=1,34).
• ŠVÉDA, M., LEGÁT, P., VRBA, R. ASI Instrumentation.  Microprocessing and Microprogramming (North-Holland).  Vol.40(1012). p. 879 – 879. ISSN 0165-6074. (IF(1998)=0,667).  [4] FICEK, R., VRBA, R., KUČEROVÁ, Z., ZAJÍČKOVÁ, L., ELIÁŠ, M., MATĚJKA, F., MATĚJKOVÁ, J., JAŠEK, O., KLAPETEK, P. Carbon nanotubes synthesized by plasma enhanced CVD: Preparation for measurements of their electrical properties. Czechoslovak Journal of Physics.  2006. (53). p. 1 – 5. ISSN 0011-4626.
• (IF(2007)=0,423).
• ŠVÉDA, M., VRBA, R. An Integrated Framework for Internet-Based Applications of Smart
• Sensors.  IEEE SENSORS JOURNAL.  2003. 3(5). p. 579  586. ISSN 1530 – 437X. (IF(2007)=1,34).
• ŠVÉDA, M., VRBA, R. Integrated smart sensor networking framework for sensorbased appliances.  IEEE SENSORS JOURNAL.  2003. 5(3). p. 579 – 586. ISSN 1530437X. (IF(2007)=1,34).
• ŠVÉDA, M., VRBA, R. Executable Specifications for Distributed  Embedded Systems. 2001. 34(1). p. 138 – 140. ISSN 0018-9162. (IF=1,062, IF(2007)=1,367).
• ŠVÉDA, M., VRBA, R. Executable specifications for embedded distributed systems. Computer. 2001. 2001(1). p. 138- 277. ISSN 00189162. (IF=1,062, IF(2007)=1,367).
• HÁZE, J.; FUJCIK, L.; VRBA, R.; PAVLÍK, M.; MICHAELI, L. The Utilization of Novel Bandpass Sigma-delta Modulator for Capacitance Pressure Sensor Signal Processing. Radioengineering. 2008. 2008(4). p. 79 – 85. ISSN 12102512.
• ŠVÉDA, M., VRBA, R. Actuator-SensorInterface Interconnectivity.  Control Engineering Practice. 7(1). p. 95- 100. ISSN 0967-0661. (IF(2007)=1,263).

CEITEC, Scientific Director for Life Sciences

Education

• 1993  D. Sc. (DrSc.)  Masaryk University,  Brno (Chemistry)
• 1983  Ph. D. (CSc.)  Komensky University, Bratislava, Slovakia    (Chemistry)
• 1979  M.S. (RNDr.)  Purkyně University, Brno (Mathematics and Chemistry)

Employment

• 1995   Full Professor
• 1988  1995 :  Associate Professor
• 1983  1988 :  Assistant Professor

Faculty member in Undegraduate and Graduate Program in Organic,  Mathematical and Computer Assisted Chemistry, Education in Chemistry, Information Technology in Chemistry, Modeling in Biochemistry and Environmental Science, Chemoinformatics and Bioinformatics, 22 Diplom students, 25 PhD students.

Research interests

Mathematical and computer assisted chemistry and biochemistry, computer assisted molecular modeling of biologically interesting chemical species, information technology in chemistry and biochemistry.  Last years mainly conformational search, molecular docking and molecular dynamics simulations on peptides, proteins, oligonucleotides, carbohydrates, and their complexes. Methods for analysis conformational potential energy surfaces and energy landscapes of chemical reactions using molecular mechanics and quantum chemistry techniques.

Publications

6 monographs, 1 textbook, over 120 journal full text papers, several computer programs and program systems ; WOS citations > 900 (autocitations excluded), H-index: 24

Management experience

One year (1994/95) Head of Chemistry Department, Fac Sci (approx. 70 employees].   In  1996, he established  and become a head (19962000) of Laboratory of Biomolecular Structure and Dynamics (about 25 people), yearly budget of about 0.2 mil. EURO. In  2001, he founded National Centre for Biomolecular Research and became director (up to now, these days about 100 people),  yearly budget more than 3 mil. EURO. Principal investigator of several national and international grants, one of the most successful in FP7 is the project POSTBIOMIN, budget over 1 mil. EURO.

Further university and academic service:

• Czech representative in Program Commitee “Ideas” of  7th FP (2006 )
• Pool of Experts to evaluate scientific proposals, European Commission FP6,  FP7, Brussels (2004)
• Member of national D.Sc. defense boards in organic chemistry and physical chemistry
• Member of  Scientific Boards: Masaryk University (MU) (19989, 2006 ),  Faculty of Science MU (19979, 2003 ), Faculty of Informatics MU (1995 )
• Member of national commission that is taking decisions about accreditation of university curricula  in Chemistry (2000 )
• Member of  Doctoral Study Boards: organic chemistry, physical chemistry, biochemistry, biophysics, biomolecular chemistry;  State examination commissions on undergraduate or doctoral levelchairman: education in chemistry, biomolecular chemistry
• Board of Directors, Czech Chemical Society (2001); National committee of  the Czech Chemical Society  (2001 ); Chairman of the Brno branch of the Czech Chemical Society (1997-    )

Faculty development

2002-2003 (CERMAV Grenoble, France – 6 months visiting professor (VP)), 199900 (Pacific Northwest National Laboratory, Richland, WA, USA – 1 year VP),  1998 (Univ. Grenoble, France – 3 months VP), 1996 (Univ. Athens, Greece  2 months VP), 1993 (Univ. Nantes, France – 4 months VP)), 1993 (Univ. of Tennessee, Knoxville, USA – 2 months  visiting researcher (VR)), 1992 (Univ. Trondheim,  Norway  – 1 month VR), 1991 (Univ. Rennes,  France  – 1 month  – teaching doctoral course), 1991 (Univ. Trondheim,  Norway  – 3 months  VP), 198890 (Univ. Trondheim,  Norway  – 2 years NTNF postdoctoral fellow), 1985  (Institute of Cybernetics  and Information Processes, Berlin, Germany  – 1 month – research stay).

Selected publications

• Koca J.: Potential Energy Hypersurface and Molecular Flexibility. J.Mol.Struct. 291, 255-269 (1993)
• Koca J., Perez S., Imberty A.: Conformational Analysis and Flexibility of Carbohydrates using the CICADA approach with MM3. J.Comput.Chem. 16, 296-310 (1995)
• Stefl R., Koca J.: Unrestrained Molecular Dynamics Simulations of d(AT5]2 Duplex in Aqueous Solution: Hydration and Sodium Ions Binding in the Minor Groove. J. Am. Chem. Soc. 122, 5025-5033 (2000)
• Koca J., Zhan Ch.G., Rittenhouse R.C., Ornstein R.: Mobility of the Active Site bound Paraoxon and Sarin in Zinc-Phosphotriesterase by Molecular Dynamics Simulation and Quantum Chemical Calculation. J. Am. Chem. Soc. 123, 817-826 (2001).
• Kulhanek P., Schlag E.W., Koca J.: A Novel Mechanism of Proton  Transfer in Protonated Peptides. J. Am. Chem. Soc. 125, 13678-13679 (2003)
• Koca J., Zhan, Ch-G., Rittenhouse R., Ornstein R.: Coordination Number of Zinc Ions in the Phosphotriesterase Active Site by Molecular Dynamics and Quantum Mechanics. J. Comput. Chem. 24, 368-378 (2003)
• Petrek, M., Otyepka, M., Banas, P., Kosinova, P., Koca, J., Damborsky, J.: CAVER: A New Tool to Explore Routes from Protein Clefts, Pockets and Cavities. BMC Bioinformatics 7, 316-324 (2006)
• Otyepka M., Bartova I., Kriz Z., Koca J.: Different Mechanisms of CDK5 and CDK2 Activation as Revealed by CDK5/P25 and CDK2/CYCLIN A Dynamics . J. Biol. Chem. 281, 7271-7281 (2006)
• Prokop M., Adam J., Kriz Z.,  Wimmerova M., Koca J.:  TRITON: a graphical tool for ligand-binding protein engineering. Bioinformatics 24, 1955-1956 (2008)
• Jirouskova Z., Svobodova Varekova R., Vanek J.,  Koca J.: Electronegativity Equalization Method: Parameterization and Validation for Organic Molecules using the Merz-Kollman-Singh Charge Distribution Scheme. J. Comput. Chem. 30,  1174-1178 (2009)

Education

2000 – MA (Mgr.) Charles University Prague (Economics)
2002 – MA (Mgr.) Charles University Prague (International relations)

Management experience

The relevant experience for the preparation of CEITEC stems mainly from his  know-how accumulated during the work for CzechInvest which covered  project management on the working level as well as management of an institution with over 300 employees responsible for hundreds of investment projects, preparation and administration of EU Operational Programs (Operational Program Enterprise and Innovation; Operational Program  Industry and Enterprise) and running several national programs aimed at enhancing competitiveness and innovativeness of the Czech economy. In addition, he has been directly responsible for two of the major foreign direct investment projects in the Czech Republic to date, i.e. the joined project of Toyota/PSA Peugeot Citroen (as the project manager) and Huyndai (as the CEO coordinating and negotiating the strategic issues on behalf of the Czech government).

CEITEC

• Project Director (since March 2009)

Constantia Privatbank AG

• Vice-President, Head of operations in the Czech Republic (2007- February 2009)

CzechInvest (National Investment and Business Development Agency)

• Chief Executive Officer (2005 – 2007)
• Director of Japanese Operations (2005)
• Director of Investment Project Dept. (2003-2005)
• Head of TPCA (Toyota Peugeot Citroen Automobile) Project Preparation Section (2002-2003)
• Project Manager (2000 – 2002)

National Centre of Biomolecular Research, Masaryk University, Brno, Czech Republic

Citation Report:

• Sum of articles WoS: 107
• Sum of articles WoS (2004 ‘ 2008):  16
• Sum of the Times Cited: 6662
• h’index : 32
• Number of patents: 2

Prof. Sklenář is a group leader of NMR laboratory and a deputy Head of National Centre for Biomolecular Research (NCBR). He has been involved in the development of NMR techniques and their applications to study the structure and dynamics of biological macromolecules for past 20 years. His methodological contributions have focused on designing novel NMR experiments for water suppression, indirect detection of low sensitive nuclei, triple’resonance measurements in C’13 and N’15 labelled RNA and DNA oligonucleotides, and for extracting accurate descriptors of inter’atomic interactions, which can be used as structural restraints for calculating spatial, three’dimensional  structures of both nucleic acids and proteins. Recently, he has used NMR to study the protein dynamics and dynamics of protein’ligand interactions using NMR relaxation measurement and spectral density mapping complemented by molecular dynamics simulations. Prof. Sklenář is involved also in theoretical calculations of NMR parameters, such as chemical shielding tensors and spin’spin scalar interactions, using modern apparatus of quantum chemistry. He has published more than 100 publications in peer’reviewed international journals, which acquired over 6800 citations, with H’index of 32. NMR laboratory is currently equipped with a 600 MHz NMR spectrometer (Bruker Avance) with the TCI cryoprobe, a 500 MHz NMR spectrometer (Bruker Avance) for spectroscopy in liquids and the CP MAS accessory for solid state measurements, and a routine  300 MHz NMR system (Bruker Avance) for the measurements in liquids. The lab  has installed and mastered a full armoury of computational tools for studies of biomolecular structure and dynamics of both proteins and nucleic acids.

Five Selected Publications:

• Macek, P., Chmelík, J., Křížová, I., Kadeřávek, P. Žídek, L., Wildová, M.,Hadravová, R., Chaloupková, R., Pichová, I.,Ruml, T., Rumlová, M., Sklenář, V.: J. Mol. Biol. 2009, in press: NMR structure of the N’terminal domain of capsid protein from the Mason’Pfizer monkey virus.
• Fiala, R. and Sklenář, V.: J. Biomol. NMR 2007, 39, 153’163: 13 C’detected NMR Experiments for Measuring Chemical Shifts and Coupling Constants in Nucleic Acid Bases.
• Křížová, H., Žídek, L., Stone, M., Novotny, M.V., and Sklenář, V., J. Biomol. NMR 2004, 28, 369’384: Temperature Dependent Backbone Dynamics of Major Urinary Protein’I Complexed with the Pheromone 2′sec’butyl’4,5′dihydrothiazole.
• Munzarová, M. and Sklenář, V., J. Amer. Chem. Soc. 2003, 125, 3649’3658: A DFT Analysis of NMR Scalar Interactions Across the Glycosidic Bond in DNA.
• Fiala, R., Czernek, J. and Sklenář, V. J. Biomol. NMR., 2000, 16, 291’302: Transverse Relaxation Optimized Triple’Resonance NMR Experiments for Nucleic Acids.

Faculty of Mechanical Engineering (FME); Brno University of Technology (BUT); Director of
Institute of Materials Science and Engineering

Citation Report:

• Sum of articles WoS: 25
• Sum of articles WoS (2004 & 2008):
• Sum of the Times Cited: 130
• h&index : 6
• Number of patents: 0

He studied physical chemistry at the Faculty of Science of Masaryk University in Brno and received MSc. degree in 1972. He defended his thesis from the field of polymer chemistry at the Czechoslovak Academy of Sciences in Prague and received PhD in 1978. He began his professional career as scientific worker at the Brno University of Technology in 1978, working in the area of physical chemistry of ceramic, polymeric and metallic materials. He habilitated in 1990. He was appointed professor of materials science and engineering in 1999. Presently, he works as professor in the Institute of Materials Science and Engineering and in the Institute of Materials Chemistry. He is Director of the Institute of Materials Science and Engineering,  Brno University of Technology. In his research work he was focused on the study of advanced inorganic and composite materials (bioceramics, engineering ceramics, nanoceramics, electronic ceramics), on methods of preparation of ceramic materials (sol&gel synthesis and injection moulding, CIP, electrophoresis, extrusion) and on the study of high&temperature processes in ceramic materials and in reactive alloys. At the last ten years he is focused on chemistry of nanoparticle materials, namely “unconventional” syntheses of nanoparticle materials (ultrasonic sonochemical synthesis, microwave synthesis and colloidal mechanochemical synthesis) and on ceramic materials for SOFCś and electrochemical membrane reactors. In the years 1993 to 2009 he was responsible researcher of 10 foreign and 14 national research projects. In addition to the above projects of fundamental research he was involved in several tens of applied research tasks for companies producing inorganic and polymeric materials.  From 1991 to 1997 he held the office of Vice&rector of the Brno University of Technology, for the sphere of science and research. In the years 1993 to 1998, he was national co&ordinator of the COST programme on behalf of the Czech Republic; presently he is the representative of the Czech Republic in the Senior Official Council of the COST programme in Brussels, a member of the Technical Committee for Chemistry of the COST programme.  In 2000 to 2003 years he was chairman of the NanoSTAG of the COST programme. In 1994 to 2009 heworked as expert of the European Commission for evaluation of international projects of the Copernicus and INCO&Copernicus programmes and 5, 6 and 7 FPś. He is chairman of the Czech Ministry of Education Board for the COST programme. He has authored over 100 scientific papers presented in journals and conferences, 6 patents, 55 research reports, and 20 projects of applied research. He is a member of five scientific societies (American Ceramic Society, Materials Research Society, Electrochemical Society, Czech Silicate Society and Czech Society for Advanced Materials).

Selected recent papers:

• J. Cihlar, H. Hadraba, K. Maca, K. Castkova: Mechanochemical synthesis of gadolinia doped ceria powders, In: Grain boundary Engineering in Electronic Materials, s. 53&59, British Ceramic Proceedings, vol. 63, London 2003.
• Merna, J., Cihlar, J., Cramail, H. Deffieux, A., Kucera, M., Polymerization of hex&1&ene initiated by diimine complexes of nickel and palladium, Eur. Polym. J., 2005, 41, 303&312
• Hermanová S., Merna J., Cihlář J., Kučera M.: Titanium complex having two phenoxy&imine chelate ligands for living ethylene polymerization, Chem. Listy 99 (S), S450 (2005)
• Merna J., Hermanová S., Cihlář J., Kučera M., Cramail H., Deffieux A.: Living polymerization of olefins initiated by nickel catalysts, Chem. Listy 99 (S), S373 (2005)
• Trunec, M., Cihlar, J., Diethelm, S.,Van Herle, J. Tubular La0.7Ca0.3Fe0.85Co0.15O3&d perovskite membranes, Part I: Preparation and properties. J. Am. Ceram. Soc., 2006, Vol. 89, No. 3, pp. 949&954.
• Trunec, M., Cihlar, J., Diethelm, S.,Van Herle, J. Tubular La0.7Ca0.3Fe0.85Co0.15O3&d perovskite membranes, Part II: Performance and stability. J. Am. Ceram. Soc., 2006, Vol. 89, No. 3, pp. 955&959.
• Cihlar, J., Del Favero, D., Cihlar, J., Buchal, A., Van Herle, J. Synthesis, structure and oxygen thermally programmed desorption spectra of La1&xCaxAlyFe1&yO3&d. J. Eur. Ceram. Soc., 2006, Vol. 26, No. 14, pp. 2999&3004.

Investment into R&D is one of the basic foundations for raising the competitiveness of the country. Financial funding for these activities is awarded in the Czech Republic by OP Research and Development for Innovation. (Celý příspěvek…)

Developmental version of website released. On friday the 3. 7. 2009 it stated with basic implementation of design and functionality.