Research Programmes
Do you know…
- … the scientists in CEITEC will be researching what happens in the brain when a human has realized that they have made a mistake?
- … there will be nearly 800 scientists in CEITEC?
- … in CEITEC we will be researching how the brain works and why some people are motivated and others are not?
- … thanks to CEITEC most of the diagnostic methods will be cheaper, faster and more comfortable for the patients?
- … 58 research teams will be created in CEITEC?
- … there will be 9 research programmes in CEITEC?
- … there will be more than 1,000 modern instruments in CEITEC?
- … more than 31,000 m2 of new infrastructure will be built in CEITEC?
- … more than 1,500 students will use the CEITEC infrastructure per year?
- … there will be 11 shared laboratories created in CEITEC?
- … CEITEC has 7 partners?
- … work will be carried out on self-cleaning surfaces in CEITEC?
- … CEITEC will co-operate closely with the industrial sector?
- … there will also be international scientists working in CEITEC?
- … CEITEC will support the international mobility of scientists?
- … the scientists in CEITEC are developing a subdermal chip which will analyse some life functions and will inform doctors from a distance?
- … the scientists in CEITEC are working on the development of a device which will enable physiotherapy from a distance?
- … the scientists at CEITEC are working on the development of biosensors?
- … CEITEC will be created in the south-Moravian city of Brno?
Molecular Medicine
Program coordinator
Program description
The majority of human diseases has genetic background, or is caused by infectious agents. Moreover, the interaction of the human body with infection is also determined genetically, both from the host, as well as from the pathogen side. The main goal of this program is:
- to introduce modern approaches of the genome analysis (human, as well as microbial)
- characterisation of cell behaviour on a molecular level, with emphasis on malignant transformation, and resistance to modern anti-cancer treatment,
- analysis of mechanisms leading to disturbances of immune response.
The main diseases studied will be cancer; neuromuscular, neurodegenerative, and metabolic diseases; infectious diseases; and quantitative and qualitative immune defects (primary and secondary immune deficiencies, allergy, autoimmunity). These goals address the actual topics in current biomedical research and clinical medicine. The project aims to bring novel findings in pathogenesis of those diseases and elaborate experimental strategies for their treatments and prevention. New approaches for genome-wide analysis including comparative and functional genomics and proteomics will enable development of specific molecular diagnostics, and hopefully, development of predictive and personalized medicine, and perhaps gene therapy. These goals will be accomplished in close cooperation with lots of other programs from the CEITEC project.
The introduction of high-capacity analysis of human and microbial genomes and the use of these technologies in medicine Analysis of transcriptomes and epigenetic changes.
Mapping of key genetic defects of tumour cells. Proteomic and genomic analysis of tumour cells with the aim of predicting a therapeutic response Analysis of cellular resistance to the modern anti-tumour therapy. Find suitable targets for gene therapy.
Molecular genetic diagnosis and characterization of neuromuscular, neurodegenerative and metabolic disorders.
Characterization of the genome of the, re-spreading sexually transmitted pathogens, the identification and characterization of genetic characteristics of microorganisms whole-genome scale.
Studying the mechanisms leading to defects in the immune response of the body, especially the quantitative and qualitative defects (primary and secondary deficiency, allergies, alergooncology, autoimmune disorders); analysis of genes involved in immune response.
Developing approaches to improve current therapeutic protocols, and experimental strategies that aim to produce new designs of therapeutic procedures.
Main goals
- Better division of patients into tumourous and hereditary diseases in prognostic groups, allowing medicine to be “made-to-measure”.
- Development of new experimental strategies to treat cancer.
- “In vitro” testing of new medicines for the treatment of selected diseases.
- Improving the treatment protocols for selected patients with cancer.
- Identification of mutations responsible for disease emergence Search for interaction between genotype and phenotype.
- Identification of new targets for diagnosis and treatment of new and re-spreading sexually transmitted pathogens.
- Mapping the routes of transmission of nosocomial infections, which will help reduce the incidence of these infections v hospital equipment.
- Epidemiological survey of sexually transmitted disease microorganisms to allow the introduction of more effective preventive measures.
- Improving the diagnosis in order to better estimate the seriousness of the infection and any allergies and autoimmune complications.
- Identification of micro-organisms associated with diseases with complex etiology, the introduction of a new treatment for these diseases.
- Clarification immunodeficiency and pathogenesis of allergic diseases, new treatments and therapies.
Photo gallery
EUROPEAN UNION