Research Programmes

• Advanced Nanotechnologies and Microtechnologies
  • Functional Properties of Nanostructures
  • Submicron Systems and Nanodevices
  • Experimental Biophotonics
  • Fabrication and Characterisation of Nanostructures
  • Development of Methods for Analysis and Measuring
  • X-ray Micro CT and Nano CT
  • Optoelectronic Characterisation of Nanostructures
  • Micro and Nanotribology
  • Plasma Technologies
  • Synthesis and Analysis of Nanostructures
  • Transport and Magnetic Properties
• Advanced Materials
  • Advanced Ceramic Materials
  • Materials for Sensors and Technological Processes Control Systems
  • Advanced Polymers and Composites
  • Advanced Metallic Materials and Metal Based Composites
  • Structure and Phase Analysis
• Structural Biology
  • Bioinformatics
  • CD Spectroscopy of Nucleic Acids and Proteins
  • CryoEM
  • Glycobiochemistry
  • RNA Quality Control
  • Nanobiotechnology
  • Biomolecular NMR Spectroscopy
  • NMR Spectroscopy II
  • NMR Spectroscopy III
  • Protein/RNA Interactions
  • X-ray Crystallography I
  • X-ray Crystallography II
  • Structure and Dynamics of Nucleic Acids
  • Structure and Interaction of Biomolecules at Surfaces
  • Computational Chemistry
• Genomics and Proteomics of Plant Systems
  • Bioanalytical Instrumentation
  • Plant Cytogenomics
  • Functional Genomics and Proteomics of Plants
  • Hormonal Crosstalk in Plant Development
  • Metabolomics
  • Core Facility – Proteomics
  • Developmental and Cell Biology of Plants
  • Chromatin Molecular Complexes
  • Developmental and Production Biology – Omics Approaches
• Molecular Medicine
  • Medical Genomics
  • Molecular Oncology I – Hematooncology
  • Molecular Oncology II – Solid Cancer
  • Inherited Diseases I – Genetic Research
  • Inherited Diseases II – Transcriptional Regulation
  • Molecular Immunology and Microbiology
  • Molecular Gastroenterology and Hepatology
  • Genome Dynamics
  • Core Facility – Genomics
  • Laboratory of Human Molecular Genetics
• Brain and Mind Research
  • Cellular and Molecular Neurobiology
  • Molecular and Functional Neuroimaging
  • Experimental and Applied Neuropsychopharmacology
  • Psychophysiology
  • Behavioural and Social Neuroscience
  • Applied Neuroscience
• Molecular Veterinary Medicine
  • Molecular Virology
  • Molecular Bacteriology
  • Parasitology
  • Food Safety
  • Orthopaedics and Surgery
  • Animal Imunogenomics
  • Animal Cytogenomics
  • Mammalian Reproduction

Orthopaedics and Surgery

Prof. MVDr. Alois Nečas, Ph.D.
Research Group Leader

THEMATIC RESEARCH FOCUS

RESEARCH AREAS

• Small animal orthopaedics
• Bone and joint surgery
• Arthroscopy

MAIN OBJECTIVES

• To obtain novel information on mechanisms of infectious diseases in domestic animals.
• Definition of the role of host genetics in infectious diseases.

CONTENT OF RESEARCH

Analysis of the causes, mechanisms and spread of infectious diseases in domestic animals

The main objective is to evaluate the clinical manifestations and to make analyses of the causes of infections in surgically treated bone and joint diseases in model animals. Despite high quality care in small animal orthopaedics, we encounter, in a certain number of patients, the development of infectious disease. The aim of this study will be to analyse the causes of infections of bones and joints in surgically treated model animals and based on the obtained results, to contribute to possible reduction of infection complications in operated patients in veterinary and human medicine.

Host genetics and comparative immugenomics

The objective is to evaluate characteristics of clinical manifestations of bone and joint infections in relation to surgical procedures in animal models for purposes of genetic analysis.

KEY RESEARCH EQUIPMENT

CURRENT RESEARCH INFRASTRUCTURE

The laboratories are currently fully equipped for the planned surgical procedures in model animals (operating theatres, surgical equipment, instrumentation, sterilisation, anaesthesia machines etc.).

MAIN PROJECTS

• Synthesis of new biomaterials and preparation of stem cell derived cells, and their aplications in for the treatment of diseases affecting human tissues derived from mesoderm: cartilage, bone, ligament and meniscus (2B06130), Ministry of Education, Youth and Sports, 2006-2011, A. Nečas, University of Veterinary and Pharmaceutical Sciences Brno, J. Motlík, Institute of Animal Physiology and Genetics AS CR, E. Syková, Institute of Experimental Medicine AS CR, P. Gál, Masaryk University, J. Jančář, Brno University of Technology.

SELECTED PUBLICATIONS

• PLANKA, L., GAL, P., KECOVA, H., KLIMA, J., HLUCILOVA, J., FILOVA, E., AMLER, E., KRUPA, P., KREN, L., SRNEC, R., URBANOVA, L., LORENZOVA, J., NECAS, A. Allogeneic and autogenous transplantations of MSCs in treatment of the physeal bone bridge in rabbits. BMC Biotechnology. 2008, 8(70), p. 70-78.
• MICKOVA, A., TOMANKOVA, K., KOLAROVA, H., BAJGAR, R., KOLAR, P., SUNKA, P., PLECNER, M., JAKUBOVA, R., BENES, J., KOLACNA, L., PLANKA, L., NECAS, A., AMLER, E. Ultrasonic shock-wave as a control mechanism for liposome drug delivery system for possible use in scaffold implanted to animals with iatrogenic articular cartilage defects. Acta Veterinaria Brno. 2007, 77(2), p. 285-289.
• JANCAR, J., SLOVIKOVA, A., AMLER, E., KRUPA, P., KECOVA, H., PLANKA, L., GAL, P., NECAS, A. Mechanical response of porous scaffolds for cartilage engineering. Physiological Research. 2007, 56, p. 17-25.
• KRUPA, P., KRSEK, P., JAVORNIK, M., DOSTAL, O., SRNEC, R., USVALD, D., PROKS, P., KECOVA, H., AMLER, E., JANCAR, J., GAL, P., PLANKA, L., NECAS, A. Use of 3D geometry modelling of osteochondrosis-like iatrogenic lesions as a template for press-and-fit scaffold seeded with mesenchymal stem cells. Physiological Research. 2007, 56, p. 107-114.
• WAGNER, K., GRIFFON, D., J., THOMAS, M., W., SCHAEFFER, D., J., SCHULZ, K., SAMII, V., F., NECAS, A. Radiographic, computed tomographic, and arthroscopic evaluation of experimental radio-ulnar incongruence in the dog. Veterinary Surgery. 2007, 36(7), p. 691-698.