- Prof. RNDr. Vladimír Sklenář, DrSc.
tel.: +420 549 497 022
Structural Biology Programme will integrate information on the structure of biologically important macromolecules – proteins, nucleic acids and their complexes. The aim is to obtain the knowledge necessary to understand the basic functions and life processes at the molecular and cellular levels. Progressive high-resolution methods of structural analysis such as X-ray diffraction, nuclear magnetic resonance, cryo-electron microscopy and tomography will be used in combination with modern methods of molecular modelling, theoretical chemistry, and bioinformatics. The programme aims to achieve European competitiveness, stimulate regional development, and provide a support for biomedical and biotechnology research.
New, integrated infrastructure, set up by the CEITEC project, will provide information crucial for the development of biochemical and biomedical technologies and therapeutic strategies for the treatment of serious illnesses. The results will find use in the pharmaceutical industry, in the monitoring of environment quality, will help to develop nanobiotechnolgies and will contribute to the development of new scientific instruments. The research will focus on molecular biology and biochemical and structural characterization of cellular processes, including RNA, studies of the ribosome, understanding the structure-function relationships of proteins in pathogenic bacteria, fungi, and viruses, and on the acquisition of knowledge necessary for the development of biosensors for nanomechanical detection of clinical markers using their in vivo/in situ detection in real time.
Brochure of Structural Biology to download
- CD Spectroscopy of Nucleic Acids and Proteins
- RNA Quality Control
- Biomolecular NMR Spectroscopy
- RNA-based Regulation of Gene Expression
- Structural Biology of Gene Regulation
- Structural Virology
- Structure and Dynamics of Nucleic Acids
- Structure and Interaction of Biomolecules at Surfaces
- Computational Chemistry