Change institution
Advanced Nano and Microtechnologies Advanced Materials Structural Biology Gen. and Prot. of Plant Systems Molecular Medicine Brain and Mind Research Molecular Vet. Medicine

Smart Nanodevices

Research Group Leader
Researcher ID
Phone: +420 54114 9255, +420 54114 6195
E-mail:
Office:

Research areas

  • Miniaturized systems (Modern electrochemical methods employing nanoelectrodes and nanopotentiostats, and other systems on a chip based on a physical transducer such as MEMS, Lab on a chip )
  • Nanostructures and nanoparticles (synthesis of nanodots, magnetic nanoparticles and modification of their surfaces for barcoding and targeted bioconjugation, nanostructured surfaces for advanced applications)
  • Nanomedicine (for diagnostics and drug delivery, in vivo imaging techniques and targeted therapy of serious diseases, molecular biology profiling of patients with tumor diseases)
  • Nanomachinery, nanorobots and nanotransporters (3D printing, molecular synthesis, liposomes, apoferritin, viral vectors)

Main objectives

Research and development of smart nanodevices

We focus on several areas of research covering modern electrochemical methods, synthesis of nanometrials such as quantum dots and magnetic nanoparticles, nanomedicine and targeted therapy as well as miniaturized devices for sensing and electronics including nonoelectrodes, nanopotentiostats, MEMS and Lab on a Chip. Moreover the application of 3D printing in nanotechnology and nanomedicine is at the centre of our interest. Finally, development of methods, techniques and technology for implementation of outputs into advance nanodevices and nanoprobes for electronics, nanomedicine and drug delivery is the main goal.

Content of research

Research and development of smart nanodevices

Development of more complex systems, both electrical and electromechanical (MEMS/NEMS) with applications in sensing, diagnostics, etc.

Miniaturized systems

The area of electrochemical analysis is a well-established group of techniques employed in our laboratory. The expertise covers a wide range of electrochemical techniques. The research in this area focusses on the utilization of different types of electrodes. Electrode modification by nanomaterials such as carbon nanotubes and nanoparticles as well as by biomolecules (peptides, proteins and nucleic acids) has been investigated. The miniaturized devices with nanoelectrodes, nanopotentiostats, and electrode array as well as microfluidic systems are the cornerstones in creating the Lab-on-chip concept. Using of flow injection analysis coupled with the robotic platform, “Orpheus”, is also of interest to us. Our research focusses on
micro-hotplates for chemical sensing, BioMEMS and Optical-MEMS. The main attention is paid to the investigation of nanostructured materials and to their characterization with respect to the application in designing and fabrication of MEMS sensors. Positive and negative (nano-)lithography, wet and dry etching processes as well as vapor depositions will be used in fabrication. MEMS systems for advanced fluidic system integrated together with electronic detectors (lab-on chip concept) will be developed. Systems will be also improved for in-vivo and in-vitro analysis of biologically interesting substances. The work will likewise include protective layers on chips for medical applications to achieve biocompatibility and to prevent negative interaction of the system (chip) with living substances/tissues of the organism.

Nanostructures and nanoparticles

Synthesis of quantum dots and magnetic nanoparticles and modification of their surface for barcoding and targeted bioconjugation.

We focus on nanomaterials such as magnetic nanoparticles and/or semiconductor nanocrystals. Magnetic nanoparticles (MNPs) are employed as an effective and versatile tool for the isolation of analytes (nucleic acids, proteins, virus, bacteria and cell) to improve significantly their detectability and simplify the process of analyte identification. Surface modification of MNPs by specific antibodies as well as versatile bioconjugation via streptavidin-biotin technology is employed to extract analytes from complex biological samples. Quantum dots (QDs), the modern fluorescent labels, with outstanding physico-chemical such as broad excitation and sharp emission spectrum, high quantum yield and low photobleaching are utilized as fluorescent tags. The wide range of materials available for QDs synthesis makes it possible to tailor properties to a specific application. Moreover, the rapid and simple preparation of QDs by microwave synthesis has been optimized. Surface modification and bioconjugation of QDs with a number of biologically active molecules and subsequent characterization by bioanalytical methods such as gel electrophoresis, capillary zone electrophoresis and/or fluorescent imaging provide a strong foundation for the investigation of benefits provided by nanomaterials.

Nanostructured surface strategy derives benefit from the very large surface areas of nanoparticles in comparison with their volumes. These advanced surfaces are advantageously used for catalytic applications, hydrophobic layers, electronics devices such as integrated electrolytic capacitors and bolometers, and nanosensing arrays. Mainly non-lithographic methods are employed in the fabrication of the surfaces bringing low-cost devices. The aspect ratio of the nanostructures can be easily tuned and nanodots, nanocolumns or nanowires can be prepared. The characteristics of such devices are set for optical, chemical, electrochemical, or mechanical properties. Template-based technology was developed and modifications of this technology are under investigation for several applications. Devices with quantum nanodots and their modifications such as biosensing arrays will be developed; also new electrolytic capacitors with film electrodes will be improved. Nanocolumns electrodes for biosensing are also investigated.

Nanomedicine for diagnostics

Nanomedicine focusses on the medical applications of nanomaterials both diagnostic and therapeutic applications. Nanocarriers for drug delivery including liposome, apoferritin and nanoparticles are employed in the transport and selective release of cytostatic drugs like platinum based ones including cisplatin, carbopaltin and oxaliplatin or doxorubicin, epirubicin and/or ellipticine. The coupling of these nanocarriers to magnetic nanoparticles via streptavidin-biotin linkage enables their targeted delivery into the cells by magnetofection. On the other hand, specifically modified quantum dots (QDs) are used for diagnostic and targeting purposes. The surfaces of the QDs are modified using antibodies and/or oligonucleotide fragments to ensure the specific interaction with targeted molecule and, therefore, effective fluorescent labelling. As an excellent tool for investigating and monitoring of transport labelled molecules through the living organism, the in vivo imaging system is used providing sensitive fluorescence based imaging coupled to high resolution X-ray modality. This system connected to inhalation anesthetic unit enables sensitive and careful handling of small animals.

Molecular biology profiling of patients with tumor diseases

Metallomics as a new interdisciplinary science arising from the growing need for knowledge of metals in the biochemistry of organisms is of great interest to us. In the field of metallomics studies, we mainly focus on protein metallothionein and its participation in various types of diseases. Particularly, its connection with tumors and neurodegenerative diseases due to its function as maintainer of metal ions metabolism is the most important one. Further, we study other metal-binding proteins including matrix metalloproteinases, prions, protein p53, zinc transporters (ZIP) and prostate specific antigen. Aside from proteins, we also focus our attention on the metabolism of metal ions such as zinc, copper and iron during various diseases. Metal-based drugs are also of interest to us.

Nanomachinery, nanorobots and nanotransporters

The suggested technologies (3D printing, molecular synthesis, liposomes, apoferritin, viral vectors) are aimed at preparing specific and smart tools for imaging and treatment assay. 3D printing enables the suggestion of suitable materials for targeted treatment of cell cultures. Nanocarriers are prepared for the application of the selected molecules into target organs and tissues. Besides these, modern techniques of molecular biology are used enabling us to modify viral particles for nanotechnological purposes.

list / cards

Name and position

E-mail

Phone

Olga Kryštofová, Ph.D.
Junior Researcher
+420 54513 3350
Soňa Křížková, Ph.D.
Junior Researcher
+420 54513 3365
Pavel Kopel, Ph.D.
Senior Researcher
+420 54513 3350
Jindřich Kynický, Ph.D.
Senior researcher
+420 54513 4037
Rajneesh Mohan
Senior researcher
+420 54114 9852, +420 77632 1078
Michal Masařík, Ph.D.
Vědecký pracovník
+420 54949 3631
Pavel Neužil
Senior Researcher
Jan Prášek, Ph.D.
Technician
+420 54114 6175
Jan Pekárek, Ph.D.
Junior researcher
+420 54114 9250, +420 726 816 192
Vojtěch Svatoš
Ph.D. student
+420 54114 9222, +420 54114 6092
Ondřej Zítka, Ph.D.
Junior researcher
+420 54114 6194, +420 54513 3350
Prof. Vojtěch Adam, Ph.D.
Senior Researcher
+420 54513 3350
Natalia Cernei, Ph.D.
Junior Researcher
+420 54513 3350
Jana Církvová
Support Staff
+420 54114 6194
Jana Drbohlavová, Ph.D.
Senior Researcher
+420 54114 9854, +420 54114 6196
Jaromír Gumulec
Support Staff
+420 54949 5809
Jaromír Hubálek, Ph.D.
Senior Researcher
+420 54114 9255, +420 54114 6195
David Hynek, Ph.D.
Junior Researcher
+420 54114 6194
Ana Maria Jimenez
Technician
Petr Čapek
Support Staff
Lukáš Fujcik, Ph.D.
specialist for the development of optical sensors
+420 54114 6133, +420 726 816 133
Zbyněk Heger, Ph.D.
Junior researcher
Jakub Kolář, Ph.D.
Junior researcher
+420 54114 9853, +420 541 146 164
Tomáš Lednický
Ph.D. student
+420 54114 9860
Michal Masařík, Ph.D.
Junior Researcher
Miguel Ángel Merlos Rodrigo
Technician
Amitava Moulick, Ph.D.
Junior Researcher
Lukáš Nejdl, Ph.D.
Junior researcher
Martina Raudenská, Ph.D.
Support Staff
Lukáš Richtera, Ph.D.
Junior researcher
Pavel Šteffan, Ph.D.
Mária Bendová
researcher - project manager
+420 54114 9848
Imrich Gablech
Ph.D. student
+420 54114 9221
Alexander Mozalev
Senior researcher
+420 54114 9849
Marian Márik
Ph.D. student
+420 54114 9861, +420 90274 1420, +420 776 495 608
Zdeněk Pytlíček
Jnior researcher
+420 54114 6288
Markéta Vaculovičová, Ph.D.
Junior Researcher
+420 54513 3350, +420 54114 6194
Martin Brtnický
Technician
Jan Hladký, Ph.D.
Junior researcher
Jiří Sochor, Ph.D.
Senior researcher
Helena Šimůnková
Core Facility Operator
+420 54114 9219
Milena Šetka
Ph.D. student
+420 54114 9864
Zdenka Fohlerová
Junior Researcher
+420 54114 9854, +420 54114 9615
David Juřička
Technician
Tomáš Urubek
Technician
Dalibor Húska
Junior researcher
Marek Remeš
Junior researcher
Dính Vinh Nguyen
Junior researcher
Dagmar Hegerová
Junior researcher
Ondřej Chmela
Ph.D. student
+420 54114 9254, +420 726 816 288
Petra Majzlíková
Junior researcher
+420 54114 6092, +420 726 816 092
Vilém Kledrowetz
Junior researcher
+420 54114 6318
Michal Horák
Support Staff
Roman Guráň
Support Staff
, +420 608 720 867
Jana Pekárková
Junior Researcher
+420 54114 6163
Roman Prokop
Junior researcher
+420 54114 6350, +420 726 816 350
Vedran Milosavljevič
Support Staff
Yazan Abdulmajeed Eyadh Haddad
Support staff - technician
Jiří Kudr
Junior researcher
Petr Michálek
Junior researcher
Evelína Polievková
Ph.D. student
+420 54114 9863
Hana Kynclová
Ph.D. student
+420 54114 6288
Miroslav Pohanka
Senior researcher
Hanadi Ananbeh
technician
Jakub Elbl
technician
Meng Feng
support staff - technician
Eliška Kabourková
junior researcher
Kristýna Šmerková
junior researcher
Pavel Švec
support staff - technician
Pavla Martinková
support staff - technician
Jakub Somer
Ph.D. student
Aneta Strejčková
support staff - technician
Helena Štuříková
support staff - technician
Petra Vičarová
support staff - technician
Martina Vršanská
support staff - technician
Pavlína Pelcová
senior researcher
Wenlei Song
Junior researcher
Stella Vallejos Vargas
Senior researcher
Radek Chmela
Support Staff
Zuzana Lacková
support staff - technician
Eliška Sedláčková
support staff - technician
Vendula Smolíková
support staff - technician
Helena Absolínová
Support staff - technician
Kateřina Kyseláková
support staff - technician
Jan Slavík
Ph.D. student
+420 54114 6288
Jelena Pejovic Simeunovic
Ph.D. student
+420 54114 9862, +420 736 169 330
Ana Mihajlović
Ph.D. student
Marie Novotná
Junior Researcher
+420 54513 3350
Jiří Šubarda
Laboratory technician
+420 54114 9623, +420 603 808 828
Radim Zahradníček
Ph.D. student
Zbyněk Šplíchal
Support Staff
Ondřej Svoboda
Ph.D. student
+420 54114 6638, +420 777 821 495
Radka Frýzová
Administrative staff
Jaroslav Klempa
Technician - student
Peter Fecko
Technician - student
Stanislav Kurdík
Stanislav Kurdík
Technician -student
Lucie Marková
support staff - technician

SELECTED PUBLICATIONS

2017

  • MILOSAVLJEVIC, V; KREJCOVA, L; GURAN, R; BUCHTELOVA, H; WAWRZAK, D; RICHTERA, L; HEGER, Z; KOPEL, P; ADAM, V, 2017:Exceptional release kinetics and cytotoxic selectivity of oxidised MWCNTs double-functionalised with doxorubicin and prostate-homing peptide. COLLOIDS AND SURFACES B-BIOINTERFACES 156 , p. 123 - 132.
  • XU, C; KYNICKY, J; SMITH, MP; KOPRIVA, A; BRTNICKY, M; URUBEK, T; YANG, YH; ZHAO, Z; HE, C; SONG, WL, 2017:Origin of heavy rare earth mineralization in South China. NATURE COMMUNICATIONS 8

2016

  • AHRBERG, CD; ILIC, BR; MANZ, A; NEUZIL, P, 2016:Handheld real-time PCR device. LAB ON A CHIP 16 (3), p. 586 - 592.
  • AHRBERG, CD; MANZ, A; NEUZIL, P, 2016:Palm-Sized Device for Point-of-Care Ebola Detection. ANALYTICAL CHEMISTRY 88 (9), p. 4803 - 4807.
  • ALMEIDA, AV; MANZ, A; NEUZIL, P, 2016:Pyrosequencing on a glass surface. LAB ON A CHIP 16 (6), p. 1063 - 1071.
  • ANJUM, NA; RODRIGO, MAM; MOULICK, A; HEGER, Z; KOPEL, P; ZITKA, O; ADAM, V; LUKATKIN, AS; DUARTE, AC; PEREIRA, E; KIZEK, R, 2016:Transport phenomena of nanoparticles in plants and animals/humans. ENVIRONMENTAL RESEARCH 151 , p. 233 - 243.
  • BENDOVA, M; BUFON, CCB; FOMIN, VM; GORANTLA, S; RUMMELI, MH; SCHMIDT, OG, 2016:Electrical Properties of Hybrid Nanomembrane/Nanoparticle Heterojunctions: The Role of Inhomogeneous Arrays. JOURNAL OF PHYSICAL CHEMISTRY C 120 (12), p. 6891 - 6899.
  • BENDOVA, M; HUBALEK, J; MOZALEV, A, 2016:Exploring Electron Transport and Memristive Switching in Nanoscale Au/WOx/W Multijunctions Based on Anodically Oxidized Al/W Metal Layers. ADVANCED MATERIALS INTERFACES 3 (19)
  • DANHEL, A; HAVRAN, L; TRNKOVA, L; FOJTA, M, 2016:Hydrogen Evolution Facilitates Reduction of DNA Guanine Residues at the Hanging Mercury Drop Electrode: Evidence for a Chemical Mechanism. ELECTROANALYSIS 28 (11), p. 2785 - 2790.
  • DONG, YC; SVOBODA, P; VRBKA, M; KOSTAL, D; URBAN, F; CIZEK, J; ROUPCOVA, P; DONG, HS; KRUPKA, I; HARTL, M, 2016:Towards near-permanent CoCrMo prosthesis surface by combining micro-texturing and low temperature plasma carburising. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS 55 , p. 215 - 227.
  • DOSTALOVA, S; CERNA, T; HYNEK, D; KOUDELKOVA, Z; VACULOVIC, T; KOPEL, P; HRABETA, J; HEGER, Z; VACULOVICOVA, M; ECKSCHLAGER, T; STIBOROVA, M; ADAM, V, 2016:Site-Directed Conjugation of Antibodies to Apoferritin Nanocarrier for Targeted Drug Delivery to Prostate Cancer Cells. ACS APPLIED MATERIALS & INTERFACES 8 (23), p. 14430 - 14441.
  • GABLECH, I; SVATOS, V; CAHA, O; HRABOVSKY, M; PRASEK, J; HUBALEK, J; SIKOLA, T, 2016:Preparation of (001) preferentially oriented titanium thin films by ion-beam sputtering deposition on thermal silicon dioxide. JOURNAL OF MATERIALS SCIENCE 51 (7), p. 3329 - 3336.
  • HADDAD, Y; HEGER, Z; ADAM, V, 2016:Guidelines for Homology Modeling of Dopamine, Norepinephrine, and Serotonin Transporters. ACS CHEMICAL NEUROSCIENCE 7 (11), p. 1607 - 1613.
  • HEGER, Z; GUMULEC, J; CERNEI, N; POLANSKA, H; RAUDENSKA, M; MASARIK, M; ECKSCHLAGER, T; STIBOROVA, M; ADAM, V; KIZEK, R, 2016:Relation of exposure to amino acids involved in sarcosine metabolic pathway on behavior of non-tumor and malignant prostatic cell lines. PROSTATE 76 (7), p. 679 - 690.
  • HEGER, Z; POLANSKA, H; RODRIGO, MAM; GURAN, R; KULICH, P; KOPEL, P; MASARIK, M; ECKSCHLAGER, T; STIBOROVA, M; KIZEK, R; ADAM, V, 2016:Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes. SCIENTIFIC REPORTS 6
  • HEGER, Z; RODRIGO, MAM; MICHALEK, P; POLANSKA, H; MASARIK, M; VIT, V; PLEVOVA, M; PACIK, D; ECKSCHLAGER, T; STIBOROVA, M; ADAM, V, 2016:Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer. PLOS ONE 11 (11)
  • HRABETA, J; ECKSCHLAGER, T; STIBOROVA, M; HEGER, Z; KRIZKOVA, S; ADAM, V, 2016:Zinc and zinc-containing biomolecules in childhood brain tumors. JOURNAL OF MOLECULAR MEDICINE-JMM 94 (11), p. 1199 - 1215.
  • KRIZKOVA, S; KEPINSKA, M; EMRI, G; RODRIGO, MAM; TMEJOVA, K; NERUDOVA, D; KIZEK, R; ADAM, V, 2016:Microarray analysis of metallothioneins in human diseases-A review. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 117 , p. 464 - 473.
  • KUDR, J; RICHTERA, L; NEJDL, L; XHAXHIU, K; VITEK, P; RUTKAY-NEDECKY, B; HYNEK, D; KOPEL, P; ADAM, V; KIZEK, R, 2016:Improved Electrochemical Detection of Zinc Ions Using Electrode Modified with Electrochemically Reduced Graphene Oxide. MATERIALS 9 (1)
  • KUPKA, V; VOJTOVA, L; FOHLEROVA, Z; JANCAR, J, 2016:Solvent free synthesis and structural evaluation of polyurethane films based on poly(ethylene glycol) and poly(caprolactone). EXPRESS POLYMER LETTERS 10 (6), p. 479 - 492.
  • MICHALEK, P; RICHTERA, L; KREJCOVA, L; NEJDL, L; KENSOVA, R; ZITKA, J; KOPEL, P; HEGER, Z; ADAM, V; KIZEK, R, 2016:Bioconjugation of peptides using advanced nanomaterials to examine their interactions in 3D printed flow-through device. ELECTROPHORESIS 37 (3), p. 444 - 454.
  • MILOSAVLJEVIC, V; HADDAD, Y; RODRIGO, MAM; MOULICK, A; POLANSKA, H; HYNEK, D; HEGER, Z; KOPEL, P; ADAM, V, 2016:The Zinc-Schiff Base-Novicidin Complex as a Potential Prostate Cancer Therapy. PLOS ONE 11 (10)
  • MOZALEV, A; BENDOVA, M; GISPERT-GUIRADO, F; PYTLICEK, Z; LLOBET, E, 2016:Metal-substrate-supported tungsten-oxide nanoarrays via porous-alumina-assisted anodization: from nanocolumns to nanocapsules and nanotubes. JOURNAL OF MATERIALS CHEMISTRY A 4 (21), p. 8219 - 8232.
  • MOZALEV, A; BENDOVA, M; VAZQUEZ, RM; PYTLICEK, Z; LLOBET, E; HUBALEK, J, 2016:Formation and gas-sensing properties of a porous-alumina-assisted 3-D niobium-oxide nanofilm. SENSORS AND ACTUATORS B-CHEMICAL 229 , p. 587 - 598.
  • NGUYEN, HV; RICHTERA, L; MOULICK, A; XHAXHIU, K; KUDR, J; CERNEI, N; POLANSKA, H; HEGER, Z; MASARIK, M; KOPEL, P; STIBOROVA, M; ECKSCHLAGER, T; ADAM, V; KIZEK, R, 2016:Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode. ANALYST 141 (9), p. 2665 - 2675.
  • RESSNEROVA, A; RAUDENSKA, M; HOLUBOVA, M; SVOBODOVA, M; POLANSKA, H; BABULA, P; MASARIK, M; GUMULEC, J, 2016:Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis. CURRENT MEDICINAL CHEMISTRY 23 (13), p. 1304 - 1330.
  • RICHTERA, L; NGUYEN, HV; HYNEK, D; KUDR, J; ADAM, V, 2016:Electrochemical speciation analysis for simultaneous determination of Cr(III) and Cr(VI) using an activated glassy carbon electrode. ANALYST 141 (19), p. 5577 - 5585.
  • SHARMA, V; HYNEK, D; TRNKOVA, L; HEMZAL, D; MARIK, M; KIZEK, R; HUBALEK, J, 2016:Electrochemical determination of adenine using a glassy carbon electrode modified with graphene oxide and polyaniline. MICROCHIMICA ACTA 183 (4), p. 1299 - 1306.
  • SKALICKOVA, S; NEJDL, L; KUDR, J; RUTTKAY-NEDECKY, B; JIMENEZ, AMJ; KOPEL, P; KREMPLOVA, M; MASARIK, M; STIBOROVA, M; ECKSCHLAGER, T; ADAM, V; KIZEK, R, 2016:Fluorescence Characterization of Gold Modified Liposomes with Antisense N-myc DNA Bound to the Magnetisable Particles with Encapsulated Anticancer Drugs (Doxorubicin, Ellipticine and Etoposide). SENSORS 16 (3)
  • SONG, WL; XU, C; SMITH, MP; KYNICKY, J; HUANG, KJ; WEI, CW; ZHOU, L; SHU, QH, 2016:Origin of unusual HREE-Mo-rich carbonatites in the Qinling orogen, China. SCIENTIFIC REPORTS 6
  • TRISKOVA, I; FIALA, R; TRNKOVA, L, 2016:Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution. ELECTROANALYSIS 28 (11), p. 2841 - 2848.
  • VASILIEV, AA; PISLIAKOV, AV; SOKOLOV, AV; SAMOTAEV, NN; SOLOVIEV, SA; OBLOV, K; GUARNIERI, V; LORENZELLI, L; BRUNELLI, J; MAGLIONE, A; LIPILIN, AS; MOZALEV, A; LEGIN, AV, 2016:Non-silicon MEMS platforms for gas sensors. SENSORS AND ACTUATORS B-CHEMICAL 224 , p. 700 - 713.
  • VESELY, R; JELINKOVA, P; HEGEROVA, D; CERNEI, N; KOPEL, P; MOULICK, A; RICHTERA, L; HEGER, Z; ADAM, V; ZITKA, O, 2016:Nanoparticles Suitable for BCAA Isolation Can Serve for Use in Magnetic Lipoplex-Based Delivery System for L, I, V, or R-rich Antimicrobial Peptides. MATERIALS 9 (4)

2015

  • AHBERG, CD; MANZ, A; NEUZIL, P, 2015:Single Fluorescence Channel-based Multiplex Detection of Avian Influenza Virus by Quantitative PCR with Intercalating Dye. SCIENTIFIC REPORTS 5
  • AHRBERG, CD; NEUZIL, P, 2015:Doubling Throughput of a Real-Time PCR. SCIENTIFIC REPORTS 5
  • ALTMEYER, MO; MANZ, A; NEUZIL, P, 2015:Microfluidic Superheating for Peptide Sequence Elucidation. ANALYTICAL CHEMISTRY 87 (12), p. 5997 - 6003.
  • ANJUM, NA; ADAM, V; KIZEK, R; DUARTE, AC; PEREIRA, E; IQBAL, M; LUKATKIN, AS; AHMAD, I, 2015:Nanoscale copper in the soil-plant system - toxicity and underlying potential mechanisms. ENVIRONMENTAL RESEARCH 138 , p. 306 - 325.
  • BABULA, P; KLEJDUS, B; KOVACIK, J; HEDBAVNY, J; HLAVNA, M, 2015:Lanthanum rather than cadmium induces oxidative stress and metabolite changes in Hypericum perforatum. JOURNAL OF HAZARDOUS MATERIALS 286 , p. 334 - 342.
  • ELIAS, M; KLOC, P; JASEK, O; MAZANKOVA, V; TRUNEC, D; HRDY, R; ZAJICKOVA, L, 2015:Atmospheric pressure barrier discharge at high temperature: Diagnostics and carbon nanotubes deposition. JOURNAL OF APPLIED PHYSICS 117 (10)
  • HASANUZZAMAN, M; HASANUZZAMAN, M; HOSSEIN, MA; THANGAVEL, P; ROYCHOUDHURY, A; GILL, SS; RODRIGO, MAM; ADAM, V; FUJITA, M; KIZEK, R; DUARTE, AC; PEREIRA, E; AHMED, I, 2015:Jacks of metal/metalloid chelation trade in plants-an overview. FRONTIERS IN PLANT SCIENCE 6
  • HEGER, Z; CERNEI, N; KRIZKOVA, S; MASARIK, M; KOPEL, P; HODEK, P; ZITKA, O; ADAM, V; KIZEK, R, 2015:Paramagnetic Nanoparticles as a Platform for FRET-Based Sarcosine Picomolar Detection. SCIENTIFIC REPORTS 5
  • HEGER, Z; MICHALEK, P; GURAN, R; HAVELKOVA, B; KOMINKOVA, M; CERNEI, N; RICHTERA, L; BEKLOVA, M; ADAM, V; KIZEK, R, 2015:Exposure to 17 beta-Oestradiol Induces Oxidative Stress in the Non-Oestrogen Receptor Invertebrate Species Eisenia fetida. PLOS ONE 10 (12)
  • JANG, M; NEUZIL, P; VOLK, T; MANZ, A; KLEBER, A, 2015:On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro. BIOMICROFLUIDICS 9 (3)
  • KRIZKOVA, S; HEGER, Z; ZALEWSKA, M; MOULICK, A; ADAM, V; KIZEK, R, 2015:Nanotechnologies in protein microarrays. NANOMEDICINE 10 (17), p. 2743 - 2755.
  • MAJZLIKOVA, P; SEDLACEK, J; PRASEK, J; PEKAREK, J; SVATOS, V; BANNOV, AG; JASEK, O; SYNEK, P; ELIAS, M; ZAJICKOVA, L; HUBALEK, J, 2015:Sensing Properties of Multiwalled Carbon Nanotubes Grown in MW Plasma Torch: Electronic and Electrochemical Behavior, Gas Sensing, Field Emission, IR Absorption. SENSORS 15 (2), p. 2644 - 2661.
  • PARK, JK; CAMPOS, CDM; NEUZIL, P; ABELMANN, L; GUIJT, RM; MANZ, A, 2015:Direct coupling of a free-flow isotachophoresis (FFITP) device with electrospray ionization mass spectrometry (ESI- MS). LAB ON A CHIP 15 (17), p. 3495 - 3502.
  • SKLENICKA, V; KUCHAROVA, K; KRAL, P; KVAPILOVA, M; SVOBODOVA, M; CMAKAL, J, 2015:The effect of hot bending and thermal ageing on creep and microstructure evolution in thick-walled P92 steel pipe. MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING 644 , p. 297 - 309.
  • SMITH, MP; CAMPBELL, LS; KYNICKY, J, 2015:A review of the genesis of the world class Bayan Obo Fe-REE-Nb deposits, Inner Mongolia, China: Multistage processes and outstanding questions. ORE GEOLOGY REVIEWS 64 , p. 459 - 476.
  • STANISAVLJEVIC, M; KRIZKOVA, S; VACULOVICOVA, M; KIZEK, R; ADAM, V, 2015:Quantum dots-fluorescence resonance energy transfer-based nanosensors and their application. BIOSENSORS & BIOELECTRONICS 74 , p. 562 - 574.
  • VACULOVICOVA, M; AKTHER, M; MAASKANT, P; BRABAZON, D; MACKA, M, 2015:Fibre coupled micro-light emitting diode array light source with integrated band-pass filter for fluorescence detection in miniaturised analytical systems. ANALYTICA CHIMICA ACTA 871 , p. 85 - 92.

2014

  • HRBAC, J; HALOUZKA, V; TRNKOVA, L; VACEK, J, 2014:eL-Chem Viewer: A Freeware Package for the Analysis of Electroanalytical Data and Their Post-Acquisition Processing. SENSORS 14 (8), p. 13943 - 13954.
  • MAJZLIKOVA, P; PRASEK, J; ELIAS, M; JASEK, O; PEKAREK, J; HUBALEK, J; ZAJICKOVA, L, 2014:Comparison of different modifications of screen-printed working electrodes of electrochemical sensors using carbon nanotubes and plasma treatment. PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE 211 (12), p. 2756 - 2764.
  • PORIZKA, P; PROCHAZKOVA, P; PROCHAZKA, D; SLADKOVA, L; NOVOTNY, J; PETRILAK, M; BRADA, M; SAMEK, O; PILAT, Z; ZEMANEK, P; ADAM, V; KIZEK, R; NOVOTNY, K; KAISER, J, 2014:Algal Biomass Analysis by Laser-Based Analytical Techniques-A Review. SENSORS 14 (9), p. 17725 - 17752.
  • VAZQUEZ, RM; MOZALEV, A; CALAVIA, R; GISPERT-GUIRADO, F; VILANOVA, X; HABAZAKI, H; LLOBET, E, 2014:Gas sensing properties of the nanostructured anodic Zr-W oxide film. SENSORS AND ACTUATORS B-CHEMICAL 204 , p. 588 - 595.

2013

  • HEGER, Z; ZITKA, O; KRIZKOVA, S; BEKLOVA, M; KIZEK, R; ADAM, V, 2013:Molecular biology of beta-estradiol-estrogen receptor complex binding to estrogen response element and the effect on cell proliferation. NEUROENDOCRINOLOGY LETTERS 34 , p. 123 - 129.
  • HERMANOVA, S; BALKOVA, R; VOBERKOVA, S; CHAMRADOVA, I; OMELKOVA, J; RICHTERA, L; MRAVCOVA, L; JANCAR, J, 2013:Biodegradation study on poly(epsilon-caprolactone) with bimodal molecular weight distribution. JOURNAL OF APPLIED POLYMER SCIENCE 127 (6), p. 4726 - 4735.
  • KENSOVA, R; BLAZKOVA, I; KONECNA, M; KOPEL, P; CHUDOBOVA, D; ZITKA, O; VACULOVICOVA, M; HYNEK, D; ADAM, V; BEKLOVA, M; KIZEK, R, 2013:Lead Ions Encapsulated in Liposomes and Their Effect on Staphylococcus aureus. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 10 (12), p. 6687 - 6700.
  • KIM, YJ; NEUZIL, P; NAM, CH; ENGELHARD, M, 2013:Deposition of Bacteriorhodopsin Protein in a Purple Membrane Form on Nitrocellulose Membranes for Enhanced Photoelectric Response. SENSORS 13 (1), p. 455 - 462.
  • KOBEROVA, M; JECMEN, T; SULC, M; CERNA, V; KIZEK, R; HUDECEK, J; STIBOROVA, M; HODEK, P, 2013:Photo-cytochrome b(5) - A New Tool to Study the Cytochrome P450 Electron-transport Chain. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 8 (1), p. 125 - 134.
  • KOMINKOVA, M; STANISAVLJEVIC, M; ZITKA, O; MAZANEK, S; SEDLACKOVA, J; BANDOUCHOVA, H; PIKULA, J; BEKLOVA, M; KIZEK, R, 2013:Yew poisoning of olive baboons (Papio anubis) in captivity: laboratory diagnosis. NEUROENDOCRINOLOGY LETTERS 34 , p. 130 - 133.
  • KRAJCAROVA, L; NOVOTNY, K; BABULA, P; PROVAZNIK, I; KUCEROVA, P; ADAM, V; MARTIN, MZ; KIZEK, R; KAISER, J, 2013:Copper Transport and Accumulation in Spruce Stems (Picea abies (L.) Karsten) Revealed by Laser-Induced Breakdown Spectroscopy. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 8 (4), p. 4485 - 4504.
  • KREJCOVA, L; NEJDL, L; HYNEK, D; KRIZKOVA, S; KOPEL, P; ADAM, V; KIZEK, R, 2013:Beads-Based Electrochemical Assay for the Detection of Influenza Hemagglutinin Labeled with CdTe Quantum Dots. MOLECULES 18 (12), p. 15573 - 15586.
  • MOHAN, R; DRBOHLAVOVA, J; HUBALEK, J, 2013:Water-dispersible TiO2 nanoparticles via a biphasic solvothermal reaction method. NANOSCALE RESEARCH LETTERS 8
  • MOZALEV, A; CALAVIA, R; VAZQUEZ, RM; GRACIA, I; CANE, C; CORREIG, X; VILANOVA, X; GISPERT-GUIRADO, F; HUBALEK, J; LLOBET, E, 2013:MEMS-microhotplate-based hydrogen gas sensor utilizing the nanostructured porous-anodic-alumina-supported WO3 active layer. INTERNATIONAL JOURNAL OF HYDROGEN ENERGY 38 (19), p. 8011 - 8021.
  • NAVRATIL, R; PILAROVA, I; JELEN, F; TRNKOVA, L, 2013:Comparative Voltammetric Analysis of Adenine and Xanthine on a Pencil Graphite Electrode in the Presence of Copper Ions. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 8 (4), p. 4397 - 4408.
  • NEJDL, L; RUTTKAY-NEDECKY, B; KUDR, J; KREMPLOVA, M; CERNEI, N; PRASEK, J; KONECNA, M; HUBALEK, J; ZITKA, O; KYNICKY, J; KOPEL, P; KIZEK, R; ADAM, V, 2013:Behaviour of Zinc Complexes and Zinc Sulphide Nanoparticles Revealed by Using Screen Printed Electrodes and Spectrometry. SENSORS 13 (11), p. 14417 - 14437.
  • PEKARIK, V; GUMULEC, J; MASARIK, M; KIZEK, R; ADAM, V, 2013:Prostate Cancer, miRNAs, Metallothioneins and Resistance to Cytostatic Drugs. CURRENT MEDICINAL CHEMISTRY 20 (4), p. 534 - 544.
  • PIKNA, L; KOVACOVA, Z; HEZELOVA, M; TRNKOVA, L, 2013:Anodic dissolution of iron microparticles in chloride-containing acetate buffer electrolytes studied by elimination voltammetry. JOURNAL OF SOLID STATE ELECTROCHEMISTRY 17 (10), p. 2687 - 2696.
  • POLJAKOVA, J; ECKSCHLAGER, T; CINATL, J; KIZEK, R; FREI, E; STIBOROVA, M, 2013:Electrochemical Determination of Enzymes Metabolizing Ellipticine in Thyroid Cancer Cells - a Tool to Explain the Mechanism of Ellipticine Toxicity to these Cells. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 8 (2), p. 1573 - 1585.
  • PRIBYLKA, A; ALMEIDA, AV; ALTMEYER, MO; PETR, J; SEVCIK, J; MANZ, A; NEUZIL, P, 2013:Fast spore breaking by superheating. LAB ON A CHIP 13 (9), p. 1695 - 1698.
  • ROP, O; MLCEK, J; JURIKOVA, T; SOCHOR, J; KIZEK, R, 2013:Antioxidant properties of saskatoon berry (Amelanchier alnifolia Nutt.) fruits. FRUITS 68 (5), p. 435 - 444.
  • RUTTKAY-NEDECKY, B; JIMENEZ, AMJ; NEJDL, L; CHUDOBOVA, D; GUMULEC, J; MASARIK, M; ADAM, V; KIZEK, R, 2013:Relevance of infection with human papillomavirus: The role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins. INTERNATIONAL JOURNAL OF ONCOLOGY 43 (6), p. 1754 - 1762.
  • RUTTKAY-NEDECKY, B; KUDR, J; NEJDL, L; MASKOVA, D; KIZEK, R; ADAM, V, 2013:G-Quadruplexes as Sensing Probes. MOLECULES 18 (12), p. 14760 - 14779.
  • SKLADANKA, J; ADAM, V; DOLEZAL, P; NEDELNIK, J; KIZEK, R; LINDUSKOVA, H; MEJIA, JEA; NAWRATH, A, 2013:How Do Grass Species, Season and Ensiling Influence Mycotoxin Content in Forage?. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 10 (11), p. 6084 - 6095.
  • SKUTKOVA, H; VITEK, M; BABULA, P; KIZEK, R; PROVAZNIK, I, 2013:Classification of genomic signals using dynamic time warping. BMC BIOINFORMATICS 14
  • SKUTKOVA, H; VITEK, M; KRIZKOVA, S; KIZEK, R; PROVAZNIK, I, 2013:Preprocessing and Classification of Electrophoresis Gel Images Using Dynamic Time Warping. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 8 (2), p. 1609 - 1622.
  • SMERKOVA, K; DOSTALOVA, S; SKUTKOVA, H; RYVOLOVA, M; ADAM, V; PROVAZNIK, I; KIZEK, R, 2013:Isolation of Xis Gen Fragment of lambda Phage from Agarose Gel Using Magnetic Particles for Subsequent Enzymatic DNA Sequencing. CHROMATOGRAPHIA 76 (42223), p. 329 - 334.

2012

  • BABULA, P; MASARIK, M; ADAM, V; ECKSCHLAGER, T; STIBOROVA, M; TRNKOVA, L; SKUTKOVA, H; PROVAZNIK, I; HUBALEK, J; KIZEK, R, 2012:Mammalian metallothioneins: properties and functions. METALLOMICS 4 (8), p. 739 - 750.
  • BABULA, P; VANCO, J; KREJCOVA, L; HYNEK, D; SOCHOR, J; ADAM, V; TRNKOVA, L; HUBALEK, J; KIZEK, R, 2012:Voltammetric Characterization of Lawsone-Copper(II) Ternary Complexes and Their Interactions with dsDNA. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (8), p. 7349 - 7366.
  • CASTILLO, G; TRNKOVA, L; HRDY, R; HIANIK, T, 2012:Impedimetric Aptasensor for Thrombin Recognition Based on CD Support. ELECTROANALYSIS 24 (5), p. 1079 - 1087.
  • CERNEI, N; ZITKA, O; RYVOLOVA, M; ADAM, V; MASARIK, M; HUBALEK, J; KIZEK, R, 2012:Spectrometric and Electrochemical Analysis of Sarcosine as a Potential Prostate Carcinoma Marker. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (5), p. 4286 - 4301.
  • DOSPIVOVA, D; HYNEK, D; KOPEL, P; BEZDEKOVA, A; SOCHOR, J; KRIZKOVA, S; ADAM, V; TRNKOVA, L; HUBALEK, J; BABULA, P; PROVAZNIK, I; VRBA, R; KIZEK, R, 2012:Electrochemical Behaviour of Apoferritin Encapsulating of Silver(I) Ions and Its Application for Treatment of Staphylococcus aureus. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (7), p. 6378 - 6395.
  • DOSPIVOVA, D; SMERKOVA, K; RYVOLOVA, M; HYNEK, D; ADAM, V; KOPEL, P; STIBOROVA, M; ECKSCHLAGER, T; HUBALEK, J; KIZEK, R, 2012:Catalytic Electrochemical Analysis of Platinum in Pt-DNA Adducts. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (4), p. 3072 - 3088.
  • DRBOHLAVOVA, J; CHOMOUCKA, J; HRDY, R; PRASEK, J; JANU, L; RYVOLOVA, M; ADAM, V; KIZEK, R; HALASOVA, T; HUBALEK, J, 2012:Effect of Nucleic Acid and Albumin on Luminescence Properties of Deposited TiO2 Quantum Dots. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (2), p. 1424 - 1432.
  • DRBOHLAVOVA, J; VOROZHTSOVA, M; HRDY, R; KIZEK, R; SALYK, O; HUBALEK, J, 2012:Self-ordered TiO2 quantum dot array prepared via anodic oxidation. NANOSCALE RESEARCH LETTERS 7 (123), p. 1 - 4.
  • GUMULEC, J; SOCHOR, J; HLAVNA, M; SZTALMACHOVA, M; KRIZKOVA, S; BABULA, P; HRABEC, R; ROVNY, A; ADAM, V; ECKSCHLAGER, T; KIZEK, R; MASARIK, M, 2012:Caveolin-1 as a potential high-risk prostate cancer biomarker. ONCOLOGY REPORTS 27 (3), p. 831 - 841.
  • HLAVNA, M; RAUDENSKA, M; HUDCOVA, K; GUMULEC, J; SZTALMACHOVA, M; TANHAUSEROVA, V; BABULA, P; ADAM, V; ECKSCHLAGER, T; KIZEK, R; MASARIK, M, 2012:MicroRNAs and zinc metabolism-related gene expression in prostate cancer cell lines treated with zinc(II) ions. INTERNATIONAL JOURNAL OF ONCOLOGY 41 (6), p. 2237 - 2244.
  • HYNEK, D; KREJCOVA, L; KRIZKOVA, S; RUTTKAY-NEDECKY, B; PIKULA, J; ADAM, V; HAJKOVA, P; TRNKOVA, L; SOCHOR, J; POHANKA, M; HUBALEK, J; BEKLOVA, M; VRBA, R; KIZEK, R, 2012:Metallomics Study of Lead-Protein Interactions in Albumen by Electrochemical and Electrophoretic Methods. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (2), p. 943 - 964.
  • HYNEK, D; KREJCOVA, L; SOCHOR, J; CERNEI, N; KYNICKY, J; ADAM, V; TRNKOVA, L; HUBALEK, J; VRBA, R; KIZEK, R, 2012:Study of Interactions between Cysteine and Cadmium(II) Ions using Automatic Pipetting System off-line Coupled with Electrochemical Analyser Dedicated United Nation Environment Program: Lead and Cadmium Initiatives. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (3), p. 1802 - 1819.
  • HYNEK, D; KREJCOVA, L; ZITKA, O; ADAM, V; TRNKOVA, L; SOCHOR, J; STIBOROVA, M; ECKSCHLAGER, T; HUBALEK, J; KIZEK, R, 2012:Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (1), p. 34 - 49.
  • HYNEK, D; KREJCOVA, L; ZITKA, O; ADAM, V; TRNKOVA, L; SOCHOR, J; STIBOROVA, M; ECKSCHLAGER, T; HUBALEK, J; KIZEK, R, 2012:Electrochemical Study of Doxorubicin Interaction with Different Sequences of Single Stranded Oligonucleotides, Part I. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (1), p. 13 - 33.
  • HYNEK, D; KRIZKOVA, S; KREJCOVA, L; GUMULEC, J; RYVOLOVA, M; CERNEI, N; MASARIK, M; ADAM, V; TRNKOVA, L; STIBOROVA, M; ECKSCHLAGER, T; HUBALEK, J; KIZEK, R, 2012:Femtogram Electroanalytical Detection of Prostatic Specific Antigen by Brdicka Reaction. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (3), p. 1749 - 1766.
  • CHOMOUCKA, J; DRBOHLAVOVA, J; MASARIK, M; RYVOLOVA, M; HUSKA, D; PRASEK, J; HORNA, A; TRNKOVA, L; PROVAZNIK, I; ADAM, V; HUBALEK, J; KIZEK, R, 2012:Nanotechnologies for society. New designs and applications of nanosensors and nanobiosensors in medicine and environmental analysis. INTERNATIONAL JOURNAL OF NANOTECHNOLOGY 9 (42255), p. 746 - 783.
  • JURIKOVA, T; ROP, O; MLCEK, J; SOCHOR, J; BALLA, S; SZEKERES, L; HEGEDUSOVA, A; HUBALEK, J; ADAM, V; KIZEK, R, 2012:Phenolic Profile of Edible Honeysuckle Berries (Genus Lonicera) and Their Biological Effects. MOLECULES 17 (1), p. 61 - 79.
  • KAISER, J; NOVOTNY, K; MARTIN, MZ; HRDLICKA, A; MALINA, R; HARTL, M; ADAM, V; KIZEK, R, 2012:Trace elemental analysis by laser-induced breakdown spectroscopy-Biological applications. SURFACE SCIENCE REPORTS 67 (42349), p. 233 - 243.
  • KIZEK, R; ADAM, V; HRABETA, J; ECKSCHLAGER, T; SMUTNY, S; BURDA, JV; FREI, E; STIBOROVA, M, 2012:Anthracyclines and ellipticines as DNA-damaging anticancer drugs: Recent advances. PHARMACOLOGY & THERAPEUTICS 133 (1), p. 26 - 39.
  • KREJCOVA, L; DOSPIVOVA, D; RYVOLOVA, M; KOPEL, P; HYNEK, D; KRIZKOVA, S; HUBALEK, J; ADAM, V; KIZEK, R, 2012:Paramagnetic particles coupled with an automated flow injection analysis as a tool for influenza viral protein detection. ELECTROPHORESIS 33 (21), p. 3195 - 3204.
  • KREJCOVA, L; FABRIK, I; HYNEK, D; KRIZKOVA, S; GUMULEC, J; RYVOLOVA, M; ADAM, V; BABULA, P; TRNKOVA, L; STIBOROVA, M; HUBALEK, J; MASARIK, M; BINKOVA, H; ECKSCHLAGER, T; KIZEK, R, 2012:Metallothionein Electrochemically Determined using Brdicka Reaction as a Promising Blood Marker of Head and Neck Malignant Tumours. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (3), p. 1767 - 1784.
  • KREMPLOVA, M; KREJCOVA, L; HYNEK, D; BARATH, P; MAJZLIK, P; HORAK, V; ADAM, V; SOCHOR, J; CERNEI, N; HUBALEK, J; VRBA, R; KIZEK, R, 2012:Automated Electrochemical Detection of Iron Ions in Erythrocytes from MeLiM Minipigs Suffering from Melanoma. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (7), p. 5893 - 5909.
  • KRIZKOVA, S; RYVOLOVA, M; HYNEK, D; ECKSCHLAGER, T; HODEK, P; MASARIK, M; ADAM, V; KIZEK, R, 2012:Immunoextraction of zinc proteins from human plasma using chicken yolk antibodies immobilized onto paramagnetic particles and their electrophoretic analysis. ELECTROPHORESIS 33 (12), p. 1824 - 1832.
  • KRYSTOFOVA, O; ZITKA, O; KRIZKOVA, S; HYNEK, D; SHESTIVSKA, V; ADAM, V; HUBALEK, J; MACKOVA, M; MACEK, T; ZEHNALEK, J; BABULA, P; HAVEL, L; KIZEK, R, 2012:Accumulation of Cadmium by Transgenic Tobacco Plants (Nicotiana tabacum L.) Carrying Yeast Metallothionein Gene Revealed by Electrochemistry. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (2), p. 886 - 907.
  • MASARIK, M; GUMULEC, J; HLAVNA, M; SZTALMACHOVA, M; BABULA, P; RAUDENSKA, M; PAVKOVA-GOLDBERGOVA, M; CERNEI, N; SOCHOR, J; ZITKA, O; RUTTKAY-NEDECKY, B; KRIZKOVA, S; ADAM, V; KIZEK, R, 2012:Monitoring of the prostate tumour cells redox state and real-time proliferation by novel biophysical techniques and fluorescent staining. INTEGRATIVE BIOLOGY 4 (6), p. 672 - 684.
  • MOZALEV, A; HABAZAKI, H; HUBALEK, J, 2012:The superhydrophobic properties of self-organized microstructured surfaces derived from anodically oxidized Al/Nb and Al/Ta metal layers. ELECTROCHIMICA ACTA 82 , p. 90 - 97.
  • NAJMANOVA, J; NEUMANNOVA, E; LEONHARDT, T; ZITKA, O; KIZEK, R; MACEK, T; MACKOVA, M; KOTRBA, P, 2012:Cadmium-induced production of phytochelatins and speciation of intracellular cadmium in organs of Linum usitatissimum seedlings. INDUSTRIAL CROPS AND PRODUCTS 36 (1), p. 536 - 542.
  • NEUZIL, P; GISELBRECHT, S; LANGE, K; HUANG, TJ; MANZ, A, 2012:Revisiting lab-on-a-chip technology for drug discovery. NATURE REVIEWS DRUG DISCOVERY 11 (8), p. 620 - 632.
  • OHNOUTKOVA, L; ZITKA, O; MRIZOVA, K; VASKOVA, J; GALUSZKA, P; CERNEI, N; SMEDLEY, MA; HARWOOD, WA; ADAM, V; KIZEK, R, 2012:Electrophoretic and chromatographic evaluation of transgenic barley expressing a bacterial dihydrodipicolinate synthase. ELECTROPHORESIS 33 (15), p. 2365 - 2373.
  • POHANKA, M; HRABINOVA, M; FUSEK, J; HYNEK, D; ADAM, V; HUBALEK, J; KIZEK, R, 2012:Electrochemical Biosensor Based on Acetylcholinesterase and Indoxylacetate for Assay of Neurotoxic Compounds Represented by Paraoxon. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (1), p. 50 - 57.
  • POHANKA, M; HYNEK, D; KRACMAROVA, A; KRUSEOVA, J; RUTTKAY-NEDECKY, B; SOCHOR, J; ADAM, V; HUBALEK, J; MASARIK, M; ECKSCHLAGER, T; KIZEK, R, 2012:Voltammetry Assay for Assessment of Oxidative Stress linked Pathologies in Brain Tumor suffered Childhood Patients. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (12), p. 11978 - 11992.
  • POHANKA, M; SOCHOR, J; RUTTKAY-NEDECKY, B; CERNEI, N; ADAM, V; HUBALEK, J; STIBOROVA, M; ECKSCHLAGER, T; KIZEK, R, 2012:Automated assay of the potency of natural antioxidants using pipetting robot and spectrophotometry. JOURNAL OF APPLIED BIOMEDICINE 10 (3), p. 155 - 167.
  • PRASEK, J; TRNKOVA, L; GABLECH, I; BUSINOVA, P; DRBOHLAVOVA, J; CHOMOUCKA, J; ADAM, V; KIZEK, R; HUBALEK, J, 2012:Optimization of Planar Three-Electrode Systems for Redox System Detection. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (3), p. 1785 - 1801.
  • ROP, O; POSOLDA, M; MLCEK, J; REZNICEK, V; SOCHOR, J; ADAM, V; KIZEK, R; SUMCZYNSKI, D, 2012:Qualities of Native Apple Cultivar Juices Characteristic of Central Europe. NOTULAE BOTANICAE HORTI AGROBOTANICI CLUJ-NAPOCA 40 (1), p. 222 - 228.
  • ROP, O; REZNICEK, V; MLCEK, J; JURIKOVA, T; SOCHOR, J; KIZEK, R; HUMPOLICEK, P; BALIK, J, 2012:Nutritional values of new Czech cultivars of Saskatoon berries (Amelanchier alnifolia Nutt.). HORTICULTURAL SCIENCE 39 (3), p. 123 - 128.
  • RYVOLOVA, M; ADAM, V; ECKSCHLAGER, T; STIBOROVA, M; KIZEK, R, 2012:Study of DNA-ellipticine interaction by capillary electrophoresis with laser-induced fluorescence detection. ELECTROPHORESIS 33 (11), p. 1545 - 1549.
  • RYVOLOVA, M; ADAM, V; KIZEK, R, 2012:Analysis of metallothionein by capillary electrophoresis. JOURNAL OF CHROMATOGRAPHY A 1226 (0), p. 31 - 42.
  • RYVOLOVA, M; HYNEK, D; SKUTKOVA, H; ADAM, V; PROVAZNIK, I; KIZEK, R, 2012:Structural changes in metallothionein isoforms revealed by capillary electrophoresis and Brdicka reaction. ELECTROPHORESIS 33 (2), p. 270 - 279.
  • RYVOLOVA, M; CHOMOUCKA, J; DRBOHLAVOVA, J; KOPEL, P; BABULA, P; HYNEK, D; ADAM, V; ECKSCHLAGER, T; HUBALEK, J; STIBOROVA, M; KAISER, J; KIZEK, R, 2012:Modern Micro and Nanoparticle-Based Imaging Techniques. SENSORS 12 (11), p. 14792 - 14820.
  • SERRANO, N; ALBERICH, A; TRNKOVA, L, 2012:Oxidation of 6-Benzylaminopurine-Copper(I) Complex on Pencil Graphite Electrode. ELECTROANALYSIS 24 (4), p. 955 - 960.
  • SIMONE, G; NEUZIL, P; PEROZZIELLO, G; FRANCARDI, M; MALARA, N; DI FABRIZIO, E; MANZ, A, 2012:A facile in situ microfluidic method for creating multivalent surfaces: toward functional glycomics. LAB ON A CHIP 12 (8), p. 1500 - 1507.
  • SOBROVA, P; RYVOLOVA, M; HUSKA, D; HUBALEK, J; PROVAZNIK, I; ADAM, V; KIZEK, R, 2012:Voltammetry of Adiponectin and its Interactions with Collagen on a Carbon Paste Electrode at Femtogram Level. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (1), p. 1 - 12.
  • SOBROVA, P; RYVOLOVA, M; HYNEK, D; ADAM, V; HUBALEK, J; KIZEK, R, 2012:Electrochemical Behaviour of Native and Denatured beta-Sheet Breaker Prion Protein. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (2), p. 928 - 942.
  • SOBROVA, P; VASATKOVA, A; SKLADANKA, J; BEKLOVA, M; ZEMAN, L; KIZEK, R; ADAM, V, 2012:Study of deoxynivalenol effect on metallothionein and glutathione levels, antioxidant capacity, and glutathione-S-transferase and liver enzymes activity in rats. CHEMICAL PAPERS 66 (12), p. 1092 - 1102.
  • SOBROVA, P; VYSLOUZILOVA, L; STEPANKOVA, O; RYVOLOVA, M; ANYZ, J; TRNKOVA, L; ADAM, V; HUBALEK, J; KIZEK, R, 2012:Tissue Specific Electrochemical Fingerprinting. PLOS ONE 7 (11), p. 1 - 12.
  • SOBROVA, P; ZEHNALEK, J; ADAM, V; BEKLOVA, M; KIZEK, R, 2012:The effects on soil/water/plant/animal systems by platinum group elements. CENTRAL EUROPEAN JOURNAL OF CHEMISTRY 10 (5), p. 1369 - 1382.
  • SOCHOR, J; HYNEK, D; KREJCOVA, L; FABRIK, I; KRIZKOVA, S; GUMULEC, J; ADAM, V; BABULA, P; TRNKOVA, L; STIBOROVA, M; HUBALEK, J; MASARIK, M; BINKOVA, H; ECKSCHLAGER, T; KIZEK, R, 2012:Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (3), p. 2136 - 2152.
  • STIBOROVA, M; ECKSCHLAGER, T; POLJAKOVA, J; HRABETA, J; ADAM, V; KIZEK, R; FREI, E, 2012:The Synergistic Effects of DNA-Targeted Chemotherapeutics and Histone Deacetylase Inhibitors As Therapeutic Strategies for Cancer Treatment. CURRENT MEDICINAL CHEMISTRY 19 (25), p. 4218 - 4238.
  • SZTALMACHOVA, M; HLAVNA, M; GUMULEC, J; HOLUBOVA, M; BABULA, P; BALVAN, J; SOCHOR, J; TANHAUSEROVA, V; RAUDENSKA, M; KRIZKOVA, S; ADAM, V; ECKSCHLAGER, T; KIZEK, R; MASARIK, M, 2012:Effect of zinc(II) ions on the expression of pro- and anti-apoptotic factors in high-grade prostate carcinoma cells. ONCOLOGY REPORTS 28 (3), p. 806 - 814.
  • VAZQUEZ, RM; CALAVIA, R; LLOBET, E; GUIRADO, F; HUBALEK, J; MOZALEV, A, 2012:The growth and gas sensing properties of mixed oxide nanocomposite thin film derived from anodically oxidized Al/Ti metal layers. 26TH EUROPEAN CONFERENCE ON SOLID-STATE TRANSDUCERS, EUROSENSOR 2012 47 , p. 833 - 836.
  • VERGARA, A; CALAVIA, R; VAZQUEZ, RM; MOZALEV, A; ABDELGHANI, A; HUERTA, R; HINES, EH; LLOBET, E, 2012:Multifrequency Interrogation of Nanostructured Gas Sensor Arrays: A Tool for Analyzing Response Kinetics. ANALYTICAL CHEMISTRY 84 (17), p. 7502 - 7510.
  • ZITKA, O; BABULA, P; SOCHOR, J; KUMMEROVA, M; KRYSTOFOVA, O; ADAM, V; HAVEL, L; BEKLOVA, M; HUBALEK, J; KIZEK, R, 2012:Determination of Eight Polycyclic Aromatic Hydrocarbons and in Pea Plants (Pisum sativum L.) Extracts by High Performance Liquid Chromatography with Electrochemical Detection. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (2), p. 908 - 927.
  • ZITKA, O; KOMINKOVA, M; SKALICKOVA, S; SKUTKOVA, H; PROVAZNIK, I; ECKSCHLAGER, T; STIBOROVA, M; ADAM, V; TRNKOVA, L; KIZEK, R, 2012:Hydrodynamic Voltammograms Profiling of Metallothionein Fragment. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 7 (11), p. 10544 - 10561.
  • ZITKA, O; MERLOS, MA; ADAM, V; FERROL, N; POHANKA, M; HUBALEK, J; ZEHNALEK, J; TRNKOVA, L; KIZEK, R, 2012:Electrochemistry of copper(II) induced complexes in mycorrhizal maize plant tissues. JOURNAL OF HAZARDOUS MATERIALS 203 (1), p. 257 - 263.
  • ZITKA, O; RYVOLOVA, M; HUBALEK, J; ECKSCHLAGER, T; ADAM, V; KIZEK, R, 2012:From Amino Acids to Proteins as Targets for Metal-based Drugs. CURRENT DRUG METABOLISM 13 (3), p. 306 - 320.
  • ZITKA, O; SKALICKOVA, S; GUMULEC, J; MASARIK, M; ADAM, V; HUBALEK, J; TRNKOVA, L; KRUSEOVA, J; ECKSCHLAGER, T; KIZEK, R, 2012:Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients. ONCOLOGY LETTERS 4 (6), p. 1247 - 1253.

2011

  • BEKLOVA, M; SOUKUPOVA, I; MAJZLIK, P; KRYSTOFOVA, O; ADAM, V; ZEHNALEK, J; KAISER, J; KIZEK, R, 2011:Various methods for detection of heavy metals in environmental samples. TOXICOLOGY LETTERS 205 , p. S191 - S192.
  • BEKLOVA, M; ZITKA, O; KRYSTOFOVA, O; SOBROVA, P; SOCHOR, J; ADAM, V; ZEHNALEK, J; KIZEK, R, 2011:A new assay for determination phytochelatin synthase activity. TOXICOLOGY LETTERS 205 , p. S62 - S62.
  • KLOSOVA, K; SERRANO, N; SALYK, O; TRNKOVA, L, 2011:Template-Assisted Fabrication and Characterization of Nanostructured Copper Electrode for Adenine Detection. CURRENT NANOSCIENCE 7 (6), p. 984 - 994.
  • KRIZKOVA, S; ZITKA, O; MASARIK, M; ADAM, V; STIBOROVA, M; ECKSCHLAGER, T; CHAVIS, GJ; KIZEK, R, 2011:Assays for determination of matrix metalloproteinases and their activity. TRAC-TRENDS IN ANALYTICAL CHEMISTRY 30 (11), p. 1819 - 1832.
  • POLJAKOVA, J; HREBACKOVA, J; DVORAKOVA, M; MOSEROVA, M; ESKSCHLAGER, T; HRABETA, J; GOTTLICHEROVA, M; KOPEJTKOVA, B; FREI, E; KIZEK, R; STIBOROVA, M, 2011:Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. NEUROENDOCRINOLOGY LETTERS 32 , p. 101 - 116.
  • PRASEK, J; DRBOHLAVOVA, J; CHOMOUCKA, J; HUBALEK, J; JASEK, O; ADAM, V; KIZEK, R, 2011:Methods for carbon nanotubes synthesis-review. JOURNAL OF MATERIALS CHEMISTRY 21 (40), p. 15872 - 15884.
  • SERRANO, N; HOLUBOVA, S; TRNKOVA, L, 2011:Acid-Base Equilibrium of 6-Benzylaminopurine and Its 4-Chloro and 4-Methoxy Derivatives in Water-Ethanol Solutions Studied by Voltammetry and Spectrophotometry. ELECTROANALYSIS 23 (9), p. 2217 - 2225.
  • SOUKUPOVA, I; BEKLOVA, M; SVOBODOVA, Z; MAJZLIK, P; SOCHOR, J; ADAM, V; TRNKOVA, L; KIZEK, R, 2011:Effect of cadmium(II) ions on level of biologically active compounds in carps and invertebrates. TOXICOLOGY LETTERS 205 , p. S69 - S70.
  • SOUKUPOVA, I; BEKLOVA, M; ZITKA, O; MAJZLIK, P; SOCHOR, J; ADAM, V; ZEHNALEK, J; KIZEK, R, 2011:An influence of platinum group elements on duckweed (Lemna minor). TOXICOLOGY LETTERS 205 , p. S77 - S77.
  • TRNKOVA, L; KRIZKOVA, S; ADAM, V; HUBALEK, J; KIZEK, R, 2011:Immobilization of metallothionein to carbon paste electrode surface via anti-MT antibodies and its use for biosensing of silver. BIOSENSORS & BIOELECTRONICS 26 (5), p. 2201 - 2207.

2010

  • BABULA, P; VANCO, J; KOHOUTKOVA, V; DANKOVA, I; OHNOUTKOVA, L; HAVEL, L; KIZEK, R, 2010:Phytotoxicity of New Complex of Lawsone with Cu(II) Ions. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 46 , p. S148 - S148.
  • CALAVIA, R; MOZALEV, A; VAZQUEZ, R; GRACIA, I; CANE, C; IONESCU, R; LLOBET, E, 2010:Fabrication of WO3 nanodot-based microsensors highly sensitive to hydrogen. SENSORS AND ACTUATORS B-CHEMICAL 149 (2), p. 352 - 361.
  • KEE, JS; POENAR, DP; NEUZIL, P; YOBAS, L; CHEN, Y, 2010:Design and fabrication of Poly(dimethylsiloxane) arrayed waveguide grating. OPTICS EXPRESS 18 (21), p. 21732 - 21742.
  • KRIZKOVA, S; KRYSTOFOVA, O; HAVEL, L; BEKLOVA, M; KIZEK, R, 2010:PROTEIN PROFILES IN PLANTS EXPOSED TO beta HEXACHLOROCYCLOHEXANE. LISTY CUKROVARNICKE A REPARSKE 126 (11), p. 401 - 402.
  • KRIZKOVA, S; MASARIK, M; KUKACKA, J; PRUSA, R; ECKSCHLAGER, T; HUBALEK, J; KIZEK, R, 2010:Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines. EJC SUPPLEMENTS 8 (5), p. 49 - 49.
  • MASARIK, M; GUMULEC, J; KUCHTICKOVA, S; KUDLACKOVA, V; JURAJDA, M; PAVLIK, D; ROVNY, A; HRABEC, R; KRIZKOVA, S; KIZEK, R, 2010:Determination of novel tumor markers in prostate carcinoma. FEBS JOURNAL 277 , p. 188 - 188.
  • OHNOUTKOVA, L; MRIZOVA, K; GALUSZKA, P; KIZEK, R; SMEDLEY, M; HARWOOD, W, 2010:Expression of Bacterial Dihydrodipicolinate Synthase in Transgenic Barley. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 46 , p. S147 - S147.
  • SHESTIVSKA, V; KRIZKOVA, S; ZITKA, O; MACKOVA, M; MACEK, T; KIZEK, R, 2010:METALLOTHIONEIN AND LOW MOLECULAR THIOL COMPOUNDS DETERMINATION IN TRANSGENIC TOBACCO EXPOSED TO CdCl2. LISTY CUKROVARNICKE A REPARSKE 126 (11), p. 403 - 403.
  • SKLADANKA, J; ADAM, V; RYANT, P; DOLEZAL, P; HAVLICEK, Z, 2010:Can Festulolium, Dactylis glomerata and Arrhenatherum elatius be used for extension of the autumn grazing season in Central Europe?. PLANT SOIL AND ENVIRONMENT 56 (10), p. 488 - 498.
  • SOCHOR, J; BABULA, P; KRSKA, B; HORNA, A; PROVAZNIK, I; HUBALEK, J; KIZEK, R, 2010:Evaluation of output signals from CoulArray detector for determination of antioxidant capacity of apricots samples. ANALYSIS OF BIOMEDICAL SIGNALS AND IMAGES , p. 209 - 214.
  • TROJAN, V; CHOMOUCKA, J; KRYSTOFOVA, O; HUBALEK, J; BABULA, P; KIZEK, R, 2010:Quantum dots (CdSe) modified by glutathione and their localization of tobacco BY-2 cells. JOURNAL OF BIOTECHNOLOGY 150 , p. S479 - S479.
  • VALLA, M; MASARIK, M; ECKSCHLAGER, T; HUBALEK, J; TRNKOVA, L; KIZEK, R; PROVAZNIK, I, 2010:Fourier Transform and Cyclic Loop for Distinguishing Catalytic Metallothionein Signals at Patient with Malignant Tumours. ANALYSIS OF BIOMEDICAL SIGNALS AND IMAGES , p. 341 - 344.

GRANTY

  • Support of the development of high-quality teams in R&D in the field of material science (CZ.1.07/2.3.00/20.0029), MEYS - OP Education for Competiteveness, 2011 - 2014
  • Nano-Electro-Bio-Tools for Biochemical and Molecularly-Biological Studies of Eukaryotic Cells (NanoBioTECell) (GAP102/11/1068), Czech Science Foundation - Standard Grants, 2011 - 2015
  • Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas (GAP301/10/0356), Czech Science Foundation - Standard Grants, 2010 - 2014
  • International Cooperation in the Field of Nanotechnologies with In Vivo Imaging Techniques (CZ.1.07/2.3.00/20.0148), MEYS - OP Education for Competiteveness, 2012 - 2014
  • Partner Network for Bionanotechnological and Metallomic Research (CZ.1.07/2.4.00/31.0023), MEYS - OP Education for Competiteveness, 2012 - 2014
  • New design and exploiting nanobiosensors and nanosensors to target medicine (KAN208130801), Academy of Sciences of the Czech Republic - Nanotechnologies for Society, 2008 - 2012

CURRENT RESEARCH INFRASTRUCTURE (not only CEITEC facility)

Clean rooms (3 µm photolithography, CVD wet oxidation, P and B diffusion from targets, magnetron sputtering of standard metals, wire bonding, FIB for nanofabrication), non-clean room facility (magnetron sputtering of special materials, thermal evaporator, profilometer, laser dicing, SEM with low vacuum analysis, EDX/WDX detectors a nanolithography in near field, chip prober with analyzer of electrical properties). In vivo imaging system with 3D analysis technology (drug delivery and cancer diagnostics), fluorescence microscope with microelectrochemical measurement technology in single cell (uncial electrochemical methods, drug effect and cell biology), fluorimeter (fluorescence of QDs, peptide, protein and DNA interaction with anticancer drugs), automatic and manual spectrometers (characterization QDs, peptide, protein and DNA interaction with anticancer drugs, interaction QDs with biomolecules), spectrophotometric analysers (metallomic analysis in biological samples, heavy metals interaction with biomolecules), capillary electrophoresis with UV/Vis, electrochemical and laser-induced fluorescence detection (nanotransportes, characterization of nanotransporters, drug analysis, interaction study), liquid chromatography (ionex chromatography biological important low molecules, sephadex chromatography for protein isolation and nano liquid chromatography for  eptide analysis , mass spectrometers (MALDI ultrafleXtrem for clinical and applied proteomics applications, ESI-Qq-TOF for molecular formula determinations and exact mass measurements), electrochemical analyzers (automatic electrochemical analyzer for protein and heavy metals detection, adsorptive transfer stripping analysis nucleic acids, testing of screen printed electrode with nanofabrication working electrode, electrochemical scanning microscope (analysis DNA or RNA on surface electrode).

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