Change institution
Advanced Nano and Microtechnologies Advanced Materials Structural Biology Gen. and Prot. of Plant Systems Molecular Medicine Brain and Mind Research Molecular Vet. Medicine

Applied Neuroscience

Research Group Leader
Researcher ID
Phone: +420 54949 7825, +420 543 182 639
E-mail: ,
Office:

Principal Investigator

Researcher ID

Prof. Josef Bednařík

Senior Researcher
Phone: +420 532 232 501
E-mail: ,
Office:
Masarykova univerzita - CEITEC MU

Research areas

  • Multimodal brain imaging and MRI biomarkers of neurodegenerative brain diseases (human and translational research)- 3 ongoing JPND grants, SoMoPro grant
  • Central and peripheral pain - FP7 grant
  • Non-invasive brain stimulation in schizophrenia and in neurodegenerative brain diseases (mild cognitive impairment, Alzheimer’s disease, Parkinson’s disease)
  • Multiple sclerosis and study of its mechanisms

Main objectives

  • Identify early diagnostic and prognostic biomarkers of Alzheimer’s disease/ Parkinson’s disease (AD/PD) (PI: I. Rektorová)
  • Combine multimodal MRI/EEG and non-invasive brain stimulation (rTMS, tCDS) to modulate cognition and behaviour in AD/PD and schizophrenia
  • Understand and control central and peripheral pain
  • Identify immunopathological mechanisms of multiple sclerosis

Content of research

The main research focus is on study of early imaging, biochemical and genetic markers of neurodegenerative brain diseases (from an animal model to human studies), pathophysiological mechanisms for neuropathic pain, immunopathological mechanisms of multiple sclerosis, and cognitive and behavioural symptoms of Parkinson’s disease, Alzheimer’s disease and schizophrenia. We particularly use multimodal brain and spinal cord imaging alone or in combination with noninvasive brain stimulation such as repetitive transcranial magnetic stimulation (rTMS). rTMS utilizes rapid magnetic pulses applied over the scalp with a small hand-held coil to induce precisely timed and localized electrical currents within the cortex of human subjects. It provides a non-invasive tool for studying pathophysiological mechanisms of various motor, cognitive and neuropsychiatric symptoms and may induce treatment effects. Other techniques have also been employed including quantitative sensory testing (QST), dynamic QST, and immunohistochemistry of dermal nerve fibers using skin biopsy. 

 

list / cards

Name and position

E-mail

Phone

Prof. Irena Rektorová, Ph.D.
Research Group Leader
+420 54949 7825, +420 543 182 639
Prof. Josef Bednařík
Senior Researcher
+420 532 232 501
Prof. Eva Češková
Senior Researcher
+420 547 192 057, +420 532 232 560, +420 532 233 706
Blanka Adamová, Ph.D.
Researcher
+420 532 232 368
Libor Ustohal, Ph.D.
Researcher
+420 532 232 074
Eva Vlčková, Ph.D.
Researcher
+420 532 232 368
Amit Suresh Khairnar, Ph.D.
Postdoctoral Researcher
Lenka Krajčovičová, Ph.D.
Postdoctoral Researcher
+420 543 182 645
Ľubomíra Anderková
PhD student
+420 54949 7766
Milena Košťálová, Ph.D.
PhD student
+420 532 232 350
Tomáš Svěrák
PhD student
+420 54949 7404
Dominik Pižem
Nela Němcová Elfmarková
PhD student
+420 54949 7766
Michaela Mayerová
PhD student
+420 532 232 074
Lucia Masárová
+420 54949 8446
Miroslav Škorňa
PhD student
+420 532 232 352
Tomáš Horák
Eva Výtvarová
+420 54949 6374
Sylvie Brustmannová
+420 54949 7404
Luboš Brabenec
+420 54949 7643
Patrik Šimko
+420 54949 7643
Monika Pupíková
+420 54949 8313
Alžběta Minsterová
+420 54949 8313
Petr Kudlička
Specialist, operator MR+EEG
+420 54949 8197
Tomáš Klail
Zoltán Galáž
Jonáš Kunst
Patrícia Klobušiaková
MR Operator
+420 54949 8446
Ilona Eliášová
PhD student
Ivana Hudcová
Assistant ICT
+420 54949 3030

SELECTED PUBLICATIONS

2017

  • VYTVAROVA, E; MARECEK, R; FOUSEK, J; STRYCEK, O; REKTOR, I., 2017:Large-scale cortico-subcortical functional networks in focal epilepsies. NeuroImage-Clinical (14), p. 28 - 34.

2016

  • ELFMARKOVA, N; GAJDOS, M; MRACKOVA, M; MEKYSKA, J; MIKL, M; REKTOROVA, I, 2016:Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control. PARKINSONISM & RELATED DISORDERS 22 , p. S52 - S55.
  • KOVALOVA, I; KERKOVSKY, M; KADANKA, Z; KADANKA, Z; NEMEC, M; JUROVA, B; DUSEK, L; JARKOVSKY, J; BEDNARIK, J, 2016:Prevalence and Imaging Characteristics of Nonmyelopathic and Myelopathic Spondylotic Cervical Cord Compression. SPINE 41 (24), p. 1908 - 1916.
  • LOSAK, J; HUTTLOVA, J; LIPOVA, P; MARECEK, R; BARES, M; FILIP, P; ZUBOR, J; USTOHAL, L; VANICEK, J; KASPAREK, T, 2016:Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study. SCHIZOPHRENIA BULLETIN 42 (6), p. 1517 - 1527.

2015

  • DROTAR, P; MEKYSKA, J; REKTOROVA, I; MASAROVA, L; SMEKAL, Z; FAUNDEZ-ZANUY, M, 2015:Decision Support Framework for Parkinson's Disease Based on Novel Handwriting Markers. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING 23 (3), p. 508 - 516.
  • LABBE, C; OGAKI, K; LORENZO-BETANCOR, O; SOTO-ORTOLAZA, AI; WALTON, RL; RAYAPROLU, S; FUJIOKA, S; MURRAY, ME; HECKMAN, MG; PUSCHMANN, A; MCCARTHY, A; LYNCH, T; SIUDA, J; OPALA, G; RUDZINSKA, M; KRYGOWSKA-WAJS, A; BARCIKOWSKA, M; CZYZEWSKI, K; SANOTSKY, Y; REKTOROVA, I; MCLEAN, PJ; RADEMAKERS, R; ERTEKIN-TANER, N; HASSAN, A; AHLSKOG, JE; BOEVE, BF; PETERSEN, RC; MARAGANORE, DM; ADLER, CH; FERMAN, TJ; PARISI, JE; GRAFF-RADFORD, NR; UITTI, RJ; WSZOLEK, ZK; DICKSON, DW; ROSS, OA, 2015:Role for the microtubule-associated protein tau variant p.A152T in risk of alpha-synucleinopathies. NEUROLOGY 85 (19), p. 1680 - 1686.

2014

  • CESKOVA, E; PRIKRYL, R; LIBIGER, J, 2014:Gender differences in the pharmacotherapy of schizophrenia. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 17 , p. 66 - 66.
  • JURA, R; SROTOVA, I; JANKU, P; ADAMOVA, B, 2014:Post-partum posterior reversible encephalopathy syndrome in a pre-eclamptic woman with twin pregnancy. EUROPEAN JOURNAL OF NEUROLOGY 21 , p. 575 - 575.
  • KRAJCOVICOVA, L; MARECEK, R; MIKL, M; REKTOROVA, I, 2014:Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects. CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS 14 (10)
  • KRAJCOVICOVA, L; MIKL, M; MARECEK, R; REKTOROVA, I, 2014:Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing. JOURNAL OF ALZHEIMERS DISEASE 41 (4), p. 1229 - 1238.
  • MAYEROVA, M; USTOHAL, L; STEHNOVA, I; PRIKRYL, R; CESKOVA, E; KASPAREK, T, 2014:Early response to risperidone treatment in the first episode of schizophrenia (FES) patients and its predictive value to subsequent response. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 17 , p. 147 - 148.
  • PRIKRYL, R; USTOHAL, L; KUCEROVA, HP; KASPAREK, T; JARKOVSKY, J; HUBLOVA, V; VRZALOVA, M; CESKOVA, E, 2014:Repetitive transcranial magnetic stimulation reduces cigarette consumption in schizophrenia patients. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 49 , p. 30 - 35.
  • REKTOROVA, I, 2014:Resting-State Networks in Alzheimer's Disease and Parkinson's Disease. NEURODEGENERATIVE DISEASES 13 (42065), p. 186 - 188.
  • REKTOROVA, I; BIUNDO, R; MARECEK, R; WEIS, L; AARSLAND, D; ANTONINI, A, 2014:Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. PLOS ONE 9 (1)
  • REKTOROVA, I; KRAJCOVICOVA, L; MARECEK, R; NOVAKOVA, M; MIKL, M, 2014:Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease. JOURNAL OF ALZHEIMERS DISEASE 42 , p. S217 - S228.
  • USTOHAL, L; PRIKRYL, R; HUBLOVA, V; MAYEROVA, M; KUCEROVA, HP; CESKOVA, E; KASPAREK, T, 2014:Severe acute dystonia/akathisia after paliperidone palmitate application - a case study. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 17 (2), p. 341 - 342.
  • VLCKOVA, E; SROTOVA, I; KINCOVA, S; PRAKSOVA, P; ADAMOVA, B; BEDNARIK, J, 2014:Evaluation of sensory and pain perception and its central modulation in chronic low back pain. EUROPEAN JOURNAL OF NEUROLOGY 21 , p. 603 - 603.

2013

  • KASPAREK, T; PRIKRYL, R; REHULOVA, J; MARECEK, R; MIKL, M; PRIKRYLOVA, H; VANICEK, J; CESKOVA, E, 2013:Brain functional connectivity of male patients in remission after the first episode of schizophrenia. HUMAN BRAIN MAPPING 34 (3), p. 726 - 737.
  • PRIKRYL, R; USTOHAL, L; KUCEROVA, HP; KASPAREK, T; VENCLIKOVA, S; VRZALOVA, M; CESKOVA, E, 2013:A detailed analysis of the effect of repetitive transcranial magnetic stimulation on negative symptoms of schizophrenia: A double-blind trial. SCHIZOPHRENIA RESEARCH 149 (42064), p. 167 - 173.

2012

  • BURSOVA, S; DUBOVY, P; VLCKOVA-MORAVCOVA, E; NEMEC, M; KLUSAKOVA, I; BELOBRADKOVA, J; BEDNARIK, J, 2012:Expression of growth-associated protein 43 in the skin nerve fibers of patients with type 2 diabetes mellitus. JOURNAL OF THE NEUROLOGICAL SCIENCES 315 (42036), p. 60 - 63.
  • CESKOVA, E, 2012:Optimizing treatment with risperidone long-acting injections. ACTA PSYCHIATRICA SCANDINAVICA 126 (6), p. 479 - 480.
  • DIVISOVA, S; VLCKOVA, E; HNOJCIKOVA, M; SKORNA, M; NEMEC, M; DUBOVY, P; DUSEK, L; JARKOVSKY, J; BELOBRADKOVA, J; BEDNARIK, J, 2012:Prediabetes/early diabetes-associated neuropathy predominantly involves sensory small fibres. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 17 (3), p. 341 - 350.
  • MITASOVA, A., KOSTALOVA, M., BEDNARIK, J., MICHALCAKOVA, R., KASPAREK, T., BALABANOVA, P., DUSEK, L., VOHANKA, S., ELY, E., W., 2012:Post-stroke delirium incidence and outcomes: Validation of the confusion assessment method for the intensive care unit (CAM-ICU). Critical Care Medicine 40 (2), p. 484 - 490.
  • REKTOR, I; GOLDEMUND, D; BEDNARIK, P; SHEARDOVA, K; MICHALKOVA, Z; TELECKA, S; DUFEK, M; REKTOROVA, I, 2012:Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease. MOVEMENT DISORDERS 27 (9), p. 1168 - 1172.
  • REKTOROVA, I; KRAJCOVICOVA, L; MARECEK, R; MIKL, M, 2012:Default Mode Network and Extrastriate Visual Resting State Network in Patients with Parkinson's Disease Dementia. NEURODEGENERATIVE DISEASES 10 (42095), p. 232 - 237.
  • SORBI, S; HORT, J; ERKINJUNTTI, T; FLADBY, T; GAINOTTI, G; GURVIT, H; NACMIAS, B; PASQUIER, F; POPESCU, BO; REKTOROVA, I; RELIGA, D; RUSINA, R; ROSSOR, M; SCHMIDT, R; STEFANOVA, E; WARREN, JD; SCHELTENS, P, 2012:EFNS-ENS Guidelines on the diagnosis and management of disorders associated with dementia. EUROPEAN JOURNAL OF NEUROLOGY 19 (9), p. 1159 - +.

2011

  • REKTOR, I; TOMCIK, J; MIKL, M; MARECEK, R; BRAZDIL, M; REKTOROVA, I, 2011:ASSOCIATION BETWEEN BASAL GANGLIA AND LARGE SCALE BRAIN NETWORKS IN EPILEPSY. EPILEPSIA 52 , p. 175 - 176.

GRANTY

  • Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for riskassessment, patient stratification and personalised pain medicine (602133), FP7 - Cooperation - Health, 2013 - 2017
  • Pre-clinical genotype-phenotype predictors of Alzheimer's disease and other dementia (237250), EU Joint Programme - Neurodegenerative Disease Research (JPND), 2014 - 2016
  • Identification of MRI based imaging biomarker in earlier detection of neuronal changes in animal models of Parkinson’s disease (4SGA8588), South Moravian Region - SoMoPro, 2015 - 2016
  • Biomarkers for Alzheimer’s disease and Parkinson’s disease, EU Joint Programme - Neurodegenerative Disease Research (JPND), 2012 - 2015
  • Multi-centre cohort-studies in Lewy-body dementia: Challenges in harmonizing different clinical and biomarker protocols, EU Joint Programme - Neurodegenerative Disease Research (JPND), 2014 - 2015
  • Effect of intensive dance-exercise intervention on cognition and brain plasticity in healthy seniors and patients with mild cognitive impairment (15-33854A), Ministry of Health - Health research agency, 2015 - 2018
  • Speech, its impairment and cognitive performance in Parkinson's disease (NT/13499), Internal grant agency - Ministry of Health, 2012 - 2015
  • Specific characteristics of neuropathic pain of central and peripheral type (NT/13523), Internal grant agency - Ministry of Health, 2012 - 2015

sedum                    jpnd

PLANNED RESEARCH INFRASTRUCTURE

Core Facility

The research group will be one of the principal users of the equipment available within CEITEC Molecular and Functional Imaging Core Facility.

CURRENT RESEARCH INFRASTRUCTURE

  • Two whole-body MR scanners Siemens Magnetom Prisma 3T
  • High density MR compatible EEG system (EGI Net Amps 400)
  • 32 channels MR compatible EEG/ExG system (Brain Products Brain AMP MR)
  • MR compatible ExG system (Brain Products Brain AMP ExG MR)
  • rTMS system with frameless stereotaxy (Deymed DuoMag XT rTMS + Brainsight TMS Navigation)
  • PATHWAY system 

duomag
rTMS system with frameless stereotaxy

 

More CEITEC News ...
Honorary Degree Ceremony

24. února 2017 10:19

Honorary Degree Ceremony

On behalf of the Rector and the Scientific Board of Masaryk University and on behalf of the Director and the Scientific Board of the Central…

Ceremonial opening of Plant Sciences Core Facility

23. února 2017 10:42

Ceremonial opening of Plant Sciences Core Facility

It is a great pleasure to invite you to the Ceremonial opening of Plant Sciences Core Facility which will take place on April 11th, 2017 at the…