Four basic approaches enabling study of the
a. subcortical structures and their interaction with the cortex
b. large scale brain networks in healthy and diseased brain predominantly cortical/ predominantly subcortical diseases (Epilepsy / Parkinson´s disease, dystonia)
Data analysis with advanced mathematical methods are performed in cooperation with ISI AS CR, CERIT MU
The project consists of two parts. First is intracranial EEG study focused on the impact of music on epilepsy. Second part involves research of the brain connectivity related to music in professional and non-professionals. This part focuses on analysis of functional connectivity and extent of brain cognitivity involvment while listening to classical music by professional players versus passive listeners. The design of the study includes listening to an excerpt of classical music chosen by the subject and listening to subject’s beforehand unknown excerpt. We will test the hypothesis whether professional players connect cognitive component more then passive listeners while listening to classical music. We will particulary focus on networks analysis.
Supported by NPU II.
Deep brain stimulation (DBS) is an effective long-term treatment for motor symptoms in advanced Parkinson's disease (PD). The most frequently used target is the subthalamic nucleus (STN). For some patients, the beneficial motor effects may be accompanied by cognitive impairment and other neuropsychiatric disturbances. Thus, we use scalp high-density EEG under on and off conditions and also intracerebral recordings of the STN combined with scalp recording in the subgroup. Advanced analytical methods are used to clarify the STN DBS impact on motor and cognitive cortical networks and correlated with longitudinal clinical examination. The project is intended to identify changes in cortical functional connectivity produced by DBS-STN stimulation in order to optimalize the treatment, and to find a possible predictive marker of cognitive impairment linked with DBS.
Supported by AZV-16-33798A Modulation of functional connectivity of the large scale cortical networks by STN DBS
This project focuses on comparison and evaluation of possible approaches for data-driven filtering of fMRI data. This kind of filtering uses signals from white matter and cerebrospinal fluid. The aim of project is to compare suitability of particular extraction options and also the exact regions from which the signals can be extracted. The criterion for comparison of particular approaches is the ammount of explained noise variability in data (desirable as high as possible) and supression of signals of neural origin (desirable as low as possible).
Supported by GA14-33143S.
The aim of the project is to design and optimize an ultra-short echo-time pulse sequence for a direct measurement of the short-T2 signals arising from white matter of the brain. There are two main obstacles to a reliable detection of myelin sheaths: 1) their signal decays to zero in a few tens of microseconds; and 2) their signal is overwhelmed by the predominant long-T2 components from white matter of the brain. The unique feature of the pulse sequence design will be a calibration procedure correcting for eddy-current induced image distortions, based on the measurement of k-space trajectory during the gradient ramp-up. The complete removal of residual long-T2 components will be achieved by optimized dual echo acquisition and subtraction, which will selectively depict signal from the short-T2 components. Following the technical development, a pilot study including healthy and multiple sclerosis volunteers will be performed to demonstrate the capabilities of the newly developed methodology for the direct myelin measurement.
Supported by Czech Science Foundation grant no. GA15-12607S
The goal of the project "Neurobiological and psychological markers of stress response and resilience in holocaust survivors and their offspring - a three generation study" is to identify the neurobiological, psychological and genetic markers of stress response and resilience in shoa (holocaust) survivors and investigate transmission of trauma in two generations of their offspring as compared to age-, gender- and education- matched control subjects.
Supported by Czech Bioimaging and Foundation for holocaust victims.
The project is focused on identification of previously unidentified brain structural or functional lesions that are potential seizure onset zones. Advanced functional and structural imaging methods will be combined to detect lesions: high density EEG; simultaneous HD EEG-fMRI; arterial spin labeling; advanced high-resolution structural imaging; diffusion tract and kurtosis imaging. We presume that subtle lesion will be defined by advanced multimodal imaging. The goal is introduction of validated protocols in the routine clinical practice.
Supported by NPU II.
list / cards
Name and position
|Prof. MUDr. Ivan Rektor, CSc.
Research Group Leader
|+420 54949 6057, +420 543 182 623|
|Martina Bočková, Ph.D.
|+420 543 182 683|
|Petr Bob, Ph.D.
|Marek Baláž, Ph.D.
|+420 543 182 645|
|Alena Damborská, Ph.D.
|+420 54949 7454, +420 532 232 050|
Researcher, MR physicist
|+420 54949 5622|
|Michal Mikl, Ph.D.
Head of Core Facility
|+420 54949 6099|
|+420 54949 5432|
Deputy Laboratory Leader, Specialist
|+420 54949 7775, +420 543 182 641|
|+420 543 182 658|
Specialist, assistant administrator electrophysiology
|+420 54949 7801|
|Anna Wojna Pelczar, Ph.D.
||+420 54949 8215|
Specialist, operator MR
|+420 54949 7774|
||+420 54949 5432|
|+420 543 183 034|
|+420 54949 4031|
||+420 775 892 513, +420 54949 3158|
|+420 54949 8446|
||+420 54949 7774|
||+420 54949 6374|
||+420 54949 7774|
|Lubomír Vojtíšek, Ph.D.
Specialist, Manager MR equipments
|+420 54949 7779|
|Michael Teodor Grey
||+420 54949 6397|
|+420 54949 8197, +420 543 182 641|
The research group will be one of the principal users of the equipment available within CEITEC Molecular and Functional Imaging Core Facility.
MR Siemens Magnetom Symphony 1.5T, MR compatible EEG (BrainAmp) 32 channels, Video EEG system (Alien) 128 channels, EEG system (BrainScope) 96 channels.
22. listopadu 2017 14:00
SPEAKER: Dr. Suzana Šegota, Ruđer Bošković Institute, Croatia TOPIC: Tuning the membrane elasticity by the ionic strength of surrounding media …
14. listopadu 2017 22:22
The most sophisticated microscopy methods of biomolecular interaction and structure analyses were introduced to young researchers and students in…