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Multimodal and Functional Imaging Laboratory

    ACCESS TO THE BOOKING SYSTEM for registred users ( for registration click here )

Head of Core Facility
Researcher ID
Phone: +420 54949 6099, +420 543 182 685
Mobile: 777926665
E-mail:
Office:

Laboratory Characteristics

czech bio logo nove

MAFIL is open CEITEC laboratory providing advanced imaging services for CEITEC research teams as well as external users. Basic techniques on which the action is based are human MR imaging and MR spectroscopy in high field (3 T) and electrophysiological techniques (high density EEG, simultaneous measurements of electrophysiology and MRI). MAFIL expertise is mainly focused on functional and structural mapping of human brain because this core-facility was designed primarily to support neuroscience research. Regarding the fact CF MAFIL performs measurements of living subjects access to laboratory services conforms to specific organizational and operational guidelines.

Unique Features

  • The first research core-facility with MRI scanners in Czech Republic installed at the university and dedicated fully for science.
  • The first research core-facility in the Czech Republic providing open-access for both national and international customers. MAFIL is part of CzechBioImaging national research infrastructure and main part of EuroBioImaging Brno node.
  • Hyperscanning (two almost identical MR scanners can be used for simultaneous fMRI measurement of two competing or cooperating subjects).
  • Multimodal and multi-parametric approaches (combining MRI with simultaneous electrophysiology; rTMS with simultaneous EEG; combining various MRI techniques like fMRI, DTI, computational neuroanatomy etc.).
  • Cutting-edge equipment (two 3T Siemens Prisma MR scanners optimized for brain research; 256-channel MR compatible EEG; specialized hardware for stimulation and response recording).
  • Access to innovative MR pulse sequences thanks to cooperation with leading brain research centers.

Services and Methodologies Provided

General overview of MR techniques

  • Anatomical imaging offering various contrasts (T1, T2-weighting, separation of water / fat, magnetization transfer).
  • Imaging of BOLD effect (functional imaging) including multiband acquisition.
  • Imaging of diffusion of water molecules (diffusion weighted images, diffusion tensor, kurtosis) including multiband acquisition.
  • Spectroscopic measurements (single-voxel spectroscopy and spectroscopic imaging) + SemiLaser and FastMap for MRS (CMRR, Minneapolis).
  • Perfusion imaging, i.e. arterial spin labelling (ASL).

General ovierview of electrophysiological techniques

  • High-density EEG (256 leads), simultaneous measurement in MR possible.
  • Standard EEG (30 leads), simultaneous measurement in MR possible.
  • Recording of electrocardiography (ECG), respiration, movement (accelerometer), skin resistance and general polygraphic signals using bipolar or unipolar leads, for e.g. electromyography (EMG) - all with the possibility of simultaneous measurement in MR.
  • rTMS (repetitive transcranial magnetic stimulation).

Key Equipment (Core Facility fully operational from 2014)

1) Two whole-body human 3T MR scanners

  • Siemens Prisma 3T, whole-body MR scanner for imaging and spectroscopy with 60 cm bore-size, powerful gradient system (max. amplitude 80 T/m with slew-rate 200 T/m/s). RF excitation use two independent channels (TimTX TrueShape technique).
  • Available coils: head/neck (64 channels), head/neck (20 channels), spine (32 channels), body (18 channels), small and large flexible (4 channels).
  • Possible triggering with ECG, breathing belt, and pulse oximeter.
  • Possible simultaneous recording of polygraphic signals (EOG, ECG, EEG, breathing, movement, EMG, ...).
  • MR scanner A is prepared for multinuclear measurements (equipped with 1H/31P head volume coil) and equipped with Tx/Rx CP Head Coil.
  • Several sequences developed or modified in prestigious foreign institutions are available (e.g. from CMRR, University of Minnesota, University of Maastricht).

2) Equipment for functional studies

  • software E-Prime for stimulation, MATLAB, etc.
  • MR compatible audio-visual stimulation for delivering of auditory and/or visual stimuli.
  • other equipment for recording of subject’s response (buttons, keyboard etc.).

3) Electrophysiological systems for measurement in EEG lab or MR

  • 256 channel MR compatible EEG system - EGI GES 400 MR system with amplifier EGI Net Amps 400, 256 channels for EEG recording, including software for correction of artefacts caused by MR and for data analysis. Several types and sizes of EEG caps are available – MR compatible EEG caps for fast application, EEG caps for long-term measurements outside of MR, and rTMS compatible low-profile caps.
  • 30 channels MR compatible EEG/ExG system - BrainProducts BrainAmpl MR / BrainAMp ExG MR, 30 EEG channels, 1 EOG channel, ExG module. ExG module enables to record other physiological signals (ECG, EMG, skin conductance, respiratory signal, movement, general bipolar electrophysiological measurements). Software for correction of artefacts caused by MR and for data analysis.
  • ExG MR compatible system - BrainProducts BrainAMp ExG MR, ExG module enables to record other physiological signals (ECG, EMG, skin conductance, respiratory signal, movement, general bipolar electrophysiological measurements). Software for correction of artefacts caused by MR and for data analysis.
  • Shielded EEG lab - the lab is prepared for measurement of high-quality electrophysiological data inside RF shielded cabin fully equipped for audio-visual stimulation and recording of interactions of measured subject during experiment. E-prime software is used for programming of stimulation. Hardware configuration of lab is prepared for simultaneous recording with EEG and ExG systems.
  • rTMS (repetitive transcranial magnetic stimulation) with frameless stereotaxy.


Czech and international researchers from universities and research institutes interested in accessing core facilities can benefit from support of research infrastructure Czech-BioImaging, funded by the Ministry of Education, Youth and Sports of the Czech Republic.

msmt

MAFIL Core Facility NEWSLETTER

VOL. 3 (1/2017)

a4_mafil_magazin_01_2017_stránka_1

VOL. 2 (2/2016)

MAFIL_newsletter_1eng

VOL. 1 (1/2016)

MAFIL_newsletter

 

list / cards

Name and position

E-mail

Phone

Michal Mikl, Ph.D.
Head of Core Facility
+420 54949 6099, +420 543 182 685
Pavel Daniel
Specialist
+420 54949 8197, +420 543 182 641
Peter Latta
Researcher, MR physicist
+420 54949 5622
Lubomír Vojtíšek, Ph.D.
Specialist, Manager MR equipments
+420 54949 7779
Martin Kojan
Specialist, Manager EEG laboratory
+420 54949 8197
Tomáš Slavíček
Specialist
+420 54949 7800
Marek Bartoň
Specialist
+420 54949 5432
Radek Mareček
Deputy Laboratory Leader, Specialist
+420 54949 7775, +420 543 182 641
Martin Lamoš
Specialist, assistant administrator electrophysiology
+420 54949 7801
Michaela Vaňharová, Ph.D.
Laboratory administrator, Specialist
+420 54949 7826, +420 54949 1342
Martin Gajdoš
Specialist
+420 54949 4031
Petr Kudlička
Specialist, operator MR+EEG
+420 54949 8197
Prof. MUDr. Ivan Rektor, CSc.
Research Group Leader
+420 54949 6057, +420 543 182 623
Veronika Fabíková
Specialist, operator MR+EEG
+420 54949 8197
Eva Štipčáková
Specialist, operator MR
+420 54949 7774
Pavla Hanzlíková
Petra Zemánková
PhD student
+420 54949 8006

SELECTED PUBLICATIONS

2017

  • VYTVAROVA, E; MARECEK, R; FOUSEK, J; STRYCEK, O; REKTOR, I., 2017:Large-scale cortico-subcortical functional networks in focal epilepsies. NeuroImage-Clinical (14), p. 28 - 34.

2016

  • DAMBORSKA, A; ROMAN, R; BRAZDIL, M; REKTOR, I; KUKLETA, M, 2016:Post-movement processing in visual oddball task - Evidence from intracerebral recording. CLINICAL NEUROPHYSIOLOGY 127 (2), p. 1297 - 1306.
  • ELFMARKOVA, N; GAJDOS, M; MRACKOVA, M; MEKYSKA, J; MIKL, M; REKTOROVA, I, 2016:Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control. PARKINSONISM & RELATED DISORDERS 22 , p. S52 - S55.
  • HEGER, Z; RODRIGO, MAM; MICHALEK, P; POLANSKA, H; MASARIK, M; VIT, V; PLEVOVA, M; PACIK, D; ECKSCHLAGER, T; STIBOROVA, M; ADAM, V, 2016:Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer. PLOS ONE 11 (11)
  • KLEIN, P; TYRLIKOVA, I; BRAZDIL, M; REKTOR, I, 2016:Brivaracetam for the treatment of epilepsy. EXPERT OPINION ON PHARMACOTHERAPY 17 (2), p. 283 - 295.
  • KUKLETA, M; DAMBORSKA, A; ROMAN, R; REKTOR, I; BRAZDIL, M, 2016:The primary motor cortex is involved in the control of a non-motor cognitive action. CLINICAL NEUROPHYSIOLOGY 127 (2), p. 1547 - 1550.
  • LOSAK, J; HUTTLOVA, J; LIPOVA, P; MARECEK, R; BARES, M; FILIP, P; ZUBOR, J; USTOHAL, L; VANICEK, J; KASPAREK, T, 2016:Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study. SCHIZOPHRENIA BULLETIN 42 (6), p. 1517 - 1527.
  • VESELY, B; REKTOR, I, 2016:The contribution of white matter lesions (WML) to Parkinson's disease cognitive impairment symptoms: A critical review of the literature. PARKINSONISM & RELATED DISORDERS 22 , p. S166 - S170.

2015

  • BEDNARIK, P; MOHEET, A; DEELCHAND, DK; EMIR, UE; EBERLY, LE; BARES, M; SEAQUIST, ER; OZ, G, 2015:Feasibility and reproducibility of neurochemical profile quantification in the human hippocampus at 3T. NMR IN BIOMEDICINE 28 (6), p. 685 - 693.
  • BEDNARIK, P; TKAC, I; GIOVE, F; DINUZZO, M; DEELCHAND, DK; EMIR, UE; EBERLY, LE; MANGIA, S, 2015:Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 35 (4), p. 601 - 610.
  • BOCKOVA, M; CHLADEK, J; JURAK, P; HALAMEK, J; STILLOVA, K; BALAZ, M; CHRASTINA, J; REKTOR, I, 2015:Complex Motor-Cognitive Factors Processed in the Anterior Nucleus of the Thalamus: An Intracerebral Recording Study. BRAIN TOPOGRAPHY 28 (2), p. 269 - 278.
  • STILLOVA, K; JURAK, P; CHLADEK, J; CHRASTINA, J; HALAMEK, J; BOCKOVA, M; GOLDEMUNDOVA, S; RIHA, I; REKTOR, I, 2015:The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study. PLOS ONE 10 (11)
  • SVATKOVA, A; MANDL, RCW; SCHEEWE, TW; CAHN, W; KAHN, RS; POL, HEH, 2015:Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls. SCHIZOPHRENIA BULLETIN 41 (4), p. 869 - 878.

2014

  • NESTRASIL, I; BEDNARIK, P; YUND, B; DELANEY, K; KOVAC, V; AHMED, A; SHAPIRO, E, 2014:Brain Mill abnormalities in mucopolysaccharidosis type I: cross-sectional Study. MOLECULAR GENETICS AND METABOLISM 111 (2), p. S81 - S81.

2013

  • BRAZDIL, M; JANECEK, J; KLIMES, P; MARECEK, R; ROMAN, R; JURAK, P; CHLADEK, J; DANIEL, P; REKTOR, I; HALAMEK, J; PLESINGER, F; JIRSA, V, 2013:On the Time Course of Synchronization Patterns of Neuronal Discharges in the Human Brain during Cognitive Tasks. PLOS ONE 8 (5)
  • KASPAREK, T; PRIKRYL, R; REHULOVA, J; MARECEK, R; MIKL, M; PRIKRYLOVA, H; VANICEK, J; CESKOVA, E, 2013:Brain functional connectivity of male patients in remission after the first episode of schizophrenia. HUMAN BRAIN MAPPING 34 (3), p. 726 - 737.

2012

  • BRAZDIL, M; MARECEK, R; URBANEK, T; KASPAREK, T; MIKL, M; REKTOR, I; ZEMAN, A, 2012:Unveiling the mystery of deja vu: The structural anatomy of deja vu. CORTEX 48 (9), p. 1240 - 1243.
  • OBHLIDALOVA, I; KERKOVSKY, M; STOURAT, P; BEDNARIK, P; VICKOVA, E, 2012:Imaging Techniques to Evaluate Morphological Correlates of Cognitive Dysfunction in Multiple Sclerosis Patients. CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE 75 (2), p. 170 - 178.
  • REKTOR, I; GOLDEMUND, D; BEDNARIK, P; SHEARDOVA, K; MICHALKOVA, Z; TELECKA, S; DUFEK, M; REKTOROVA, I, 2012:Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease. MOVEMENT DISORDERS 27 (9), p. 1168 - 1172.

2011

  • REKTOR, I; TOMCIK, J; MIKL, M; MARECEK, R; BRAZDIL, M; REKTOROVA, I, 2011:ASSOCIATION BETWEEN BASAL GANGLIA AND LARGE SCALE BRAIN NETWORKS IN EPILEPSY. EPILEPSIA 52 , p. 175 - 176.

PROJECTS

  • RIAT-CZ (ATCZ40), Interreg CZ-AT, 2016 - 2018
  • Czech-BioImaging - National Infrastructure for Biological and Medical Imaging (LM2015062), MEYS, 2016 - 2019
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Equipment Research group / CF Profile card
EEG systém EEG systém
CF: Multimodal and Functional Imaging Laboratory
MR compatible EEG/polygraphic system supports a variety of electrophysiological measurements (EEG, ECG, respiration, skin resistance, EMG, etc.) MR compatible EEG/polygraphic system supports a variety of electrophysiological measurements (EEG, ECG, respiration, skin resistance, EMG, etc.)
CF: Multimodal and Functional Imaging Laboratory
MR compatible polygraphic system supports a variety of electrophysiological measurements (ECG, respiration, skin resistance, EMG, etc.) MR compatible polygraphic system supports a variety of electrophysiological measurements (ECG, respiration, skin resistance, EMG, etc.)
CF: Multimodal and Functional Imaging Laboratory
MR compatible stimulation system MR compatible stimulation system
CF: Multimodal and Functional Imaging Laboratory
TMS (transcranial magnetic stimulation) with frameless stereotaxy CF: Multimodal and Functional Imaging Laboratory
Whole-body human  3T MR scanner Whole-body human 3T MR scanner
CF: Multimodal and Functional Imaging Laboratory
Whole-body human  3T MR scanner Whole-body human 3T MR scanner
CF: Multimodal and Functional Imaging Laboratory

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