Characterization of enzymes oxidizing the tyrosine kinase inhibitor vandetanib and elucidation of the high efficiency of cytochrome P450 3A4 to generate N-desmethylvandetanib

TOXICOLOGY LETTERS

INDRA, R.; VÁVROVÁ, K.; TAKÁCSOVÁ, P.; POMPACH, P.; MARTÍNEK, V.; HEGER, Z.; ADAM, V.; ARLT, V.; STIBOROVÁ, M, 2019: Characterization of enzymes oxidizing the tyrosine kinase inhibitor vandetanib and elucidation of the high efficiency of cytochrome P450 3A4 to generate N-desmethylvandetanib. TOXICOLOGY LETTERS 314, p. S130 - 1; FULL TEXT

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