1. Characterizing sequence-structure-function relationships: A multi-dimensional approach for evaluating similarity in structural biology data
Supervisor: prof. Jaroslav Koča
Consultants: Crina-Maria Ionescu, Ph.D.
Annotation: Understanding the similarity between the sequence and/or structure of biomolecules has been key to inferring evolutionary relationships and predicting the function of biomolecules. We propose a novel approach for defining and evaluating the similarity between biomolecules. The approach is based on representing structural biology data as a square matrix of biomolecular structure elements and their properties; we then define similarity as the result of comparing the eigenvalues and eigenvector spaces determined for the biomolecules compared. Such a test of statistical similarity is intended to determine whether the compared biomolecules share features of structure, function, biological pathway, or affinity for a certain range of binding partners.
RG: Jaroslav Koča Research Group
Keywords: biomolecules, sequence-structure-function relationship, data analysis