|Phone:||+420 54949 7807|
|Research group:||Behavioural and Social Neuroscience - Milan Brázdil|
Research Interests: My research focuses on mapping the human brain in health and disease and particularly on biomarkers and underlying mechanisms of psychiatric diseases. This builds upon my expertise in population neuroscience, neuroimaging, and social neuroscience.
In my largest study so far, I focus on the neural-hormonal coupling during negative affect in patients with depression, bipolar disorder, and schizophrenia. I am verifying the presence of the neural and hormonal signatures of depressive symptomatology, which might possibly serve as early biomarkers, in a cohort of typically developing young adults. I am also interested in the comorbidity of psychiatric disorders with general medical disorders such as cardiovascular disease and obesity.
Thanks to the access to several European and North American cohort studies, I can take a life-course perspective and investigate the early origins of adult diseases. Starting with small-scale experimental studies focused on the sources of altered brain structure and function (e.g., studies of the impact of prenatal and pubertal androgens, studies of the role of menstrual cycle and the use oral contraception on brain function, studies on the effects of short term sleep deprivation on structural fluctuations in white matter), we can verify the results on samples from hundreds of individuals to improve our confidence in the findings. In particular, I am interested in prenatal and early postnatal exposures (stress, proinflammatory cytokines, androgens), development during adolescence, and their impact on health in adulthood.
- University of Toronto (prof. Paus, prof. Pausova)
- Harvard Medical School (prof. Goldstein)
Grants in the past:
- Biomarkers and underlying mechanisms of vulnerability to depression (FP7-PEOPLE-2013-IEF) - Marie Curie Fellow
- Sleep deprivation and structural fluctuations in white matter (funding from MŠMT and Child Mind Institute) - Local Coordinator
Bio: Dr. Klára Marečková is a Marie Curie Fellow in the Behavioral and Social Neuroscience (BeSoN) research group at the Central European Institute of Technology, Masaryk University. She received her M.Sc. in Cognitive Neuroscience and Neuroimaging at the University of Nottingham (UK) in 2008. In 2009, she moved to Canada to start her PhD at the Rotman Research Institute, Baycrest, under the supervision of prof. Tomas Paus. She defended her PhD thesis entitled Sex differences and the role of sex hormones on face development and face processing in 2013 and moved with her husband to their home town of Brno, Czech Republic, where she joined the BeSoN research group as a postdoctoral fellow. This position enabled her to focus on clinical neuroscience, develop a close collaboration with prof. Goldstein’s team at Harvard Medical School (US), and work with 50-year worth of data from New England Family Study. Her current work funded by Marie Curie grant (FP7-2013-IEF) enriches the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with neuroimaging (structural, functional and diffusion MRI), physiological, hormonal and behavioural data and studies Biomarkers and underlying mechanisms of vulnerability to depression (VULDE). Together with Prof. Paus, Klara also developed a collaboration between CEITEC MU and the Child Mind Institute in New York (US) and studies the effects of sleep deprivation on structural fluctuations in white matter. In addition, she serves as a reviewer for a number of peer reviewed journals (e.g. Brain Structure and Function, Neuroimage, Psychoneuroendocrinology, Hormones and Behavior), conferences (e.g. OHBM), and grant proposals (e.g. H2020).
8. Nov. 2017
Stress in pregnancy may lead to more susceptibility of children to depression, Klára Marečková from CEITEC Masaryk University discovered. More…
- Marečková, K.; Mareček, R.; Bencurova, P.; Klánová, J.; Dušek, L.; Brázdil, M., 2018: Perinatal stress and human hippocampal volume: Findings from typically developing young adults. SCIENTIFIC REPORTS , doi: 10.1038/s41598-018-23046-6
- Mareckova, K; Klasnja, A; Bencurova, P; Andyýskova, L; Brazdil, M; Paus, T, 2018: Prenatal stress, mood and gray matter volume in young adulthood. CEREBRAL CORTEX
- Mareckova, K; Holsen, L; Admon, R; Whitfield-Gabrieli, S; Seidman, LJ; Buka, SL; Klibanski, A; Goldstein, JM, 2017: Neural - hormonal responses to negative affective stimuli: Impact of dysphoric mood and sex. JOURNAL OF AFFECTIVE DISORDERS 222, p. 88 - 97, doi: 10.1016/j.jad.2017.06.050
- Mareckova, K; Holsen, LM; Admon, R; Makris, N; Seidman, L; Buka, S; Whitfield-Gabrieli, S; Goldstein, JM, 2016: Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses. HUMAN BRAIN MAPPING 37(11), p. 3733 - 3744, doi: 10.1002/hbm.23271
- Garcia, R; Mareckova, K; Fluegel, B; Holsen, L; Aizley, H; Remington, A; Whitfield-Gabrieli, S; Barbieri, R; Napadow, V; Goldstein, J, 2015: Central Modulation of Parasympathetic Response to Negative Affect is Disrupted in Major Depression: Impact of Sex. NEUROPSYCHOPHARMACOLOGY 40, p. S157 - S158
- Mareckova, K; Holsen, L; Admon, R; Whitfield-Gabrieli, S; Goldstein, J, 2015: Neural and Hormonal Responses to Negative Affective Stimuli: Impact of Sex and Depressed Mood. NEUROPSYCHOPHARMACOLOGY 40, p. S176 - S177
- Mareckova, K; Chakravarty, MM; Lawrence, C; Leonard, G; Perusse, D; Perron, M; Pike, BG; Richer, L; Veillette, S; Pausova, Z; Paus, T, 2015: Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development. BRAIN STRUCTURE & FUNCTION 220(6), p. 3233 - 3244, doi: 10.1007/s00429-014-0852-3
- Mareckova, K; Holsen, L; Admon, R; Whitfield-Gabrieli, S; Goldstein, J, 2014: Mood Dysregulation and Stress Response Circuitry Deficits: Impact of Diagnosis, Mood State, and Sex. NEUROPSYCHOPHARMACOLOGY 39, p. S201 - S202
- Mareckova, K; Perrin, JS; Nawaz Khan, I; Lawrence, C; Dickie, E; McQuiggan, DA; Paus, T; IMAGEN Consortium, 2014: Hormonal contraceptives, menstrual cycle and brain response to faces. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE 2(9), p. 191 - 200
- Mareckova, K; Chakravarty, MM; Huang, M; Lawrence, C; Leonard, G; Perron, M; Pike, BG; Richer, L; Veillette, S; Pausova, Z; Paus, T, 2013: Does skull shape mediate the relationship between objective features and subjective impressions about the face?. NEUROIMAGE 79(79), p. 234 - 240, doi: 10.1016/j.neuroimage.2013.04.110
- Tahmasebi, AM; Artiges, E; Banaschewski, T; Barker, GJ; Bruehl, R; Buchel, C; Conrod, PJ; Flor, H; Garavan, H; Gallinat, J; Heinz, A; Ittermann, B; Loth, E; Mareckova, K; Martinot, JL; Poline, JB; Rietschel, M; Smolka, MN; Strohle, A; Schumann, G; Paus, T, 2012: Creating probabilistic maps of the face network in the adolescent brain: A multicentre functional MRI study. HUMAN BRAIN MAPPING 33(4), p. 938 - 957, doi: 10.1002/hbm.21261
- Mareckova, K; Weinbrand, Z; Chakravarty, M M; Lawrence, C; Aleong, R; Leonard, G; Perron, M; Pike, B G; Richer, L; Veillette, S; Pausova, Z; Paus, T, 2011: Testosterone-mediated sex differences in the face shape during adolescence: subjective impressions and objective features. HORMONES AND BEHAVIOR 5(60), p. 681 - 690, doi: 10.1016/j.yhbeh.2011.09.004
- CEITEC - Central European Institute of Technology (CZ.1.05/1.1.00/02.0068), Ministerstvo školství, mládeže a tělovýchovy ČR, 2011 - 2015
- Optimalizace metodiky analýzy a hodnocení simultánního EEG-fMRI u pacientů s farmakorezistentní epilepsií (GAP304/11/1318), Grantová agentura ČR, 2011 - 2013
- Individuální rozdíly v diferenciaci mezi reprezentací sebe a druhých lidí (GA15-16738S), Grantová agentura ČR, 2015 - 2017
- Understanding empathy using a second person neuroscience approach – a multimodal hyperscanning study combining fMRI and scalp EEG (7AMB15AT015), Ministerstvo školství, mládeže a tělovýchovy ČR, 2015 - 2016
- Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci (CZ.1.07/2.3.00/30.0009), Ministerstvo školství, mládeže a tělovýchovy ČR, 2012 - 2015
- Promoting stability and resilience in high-risk youth: AdoEHealth (MUNI/F/0055/2017), Masarykova univerzita, 2017 - 2017
- Biomarkers and underlying mechanisms of vulnerability to depression, Evropská unie, 2015 - 2017
- Economic Decision-Making: Hormonal Determinants and Ritualized Behavior, Masarykova univerzita, 2018 - 2020