PhD Position – Mass spectrometric imaging of biological tissues

Research Position | Published on 20.12.2019 | CEITEC MU

Mass spectrometry imaging (MSI) exploits the ability of mass spectrometry to identify molecules according to their specific mass and image their distribution across the sample. The method allows direct visualization of endogenous compounds (lipids, proteins, small molecules) as well as exogenous drugs and their metabolites.  

Supervisor: Jan Preisler

Topic description:

The aim of the research will be development of a suitable matrix-assisted laser desorption/ionization (MALDI) MSI method for the study of distribution and the effect of chosen drug selected tissues and cell lines. Special attention will be devoted to sample preparation and matrix deposition (spray, sublimation, piezoelectric dispenser) and data processing. The samples will be supplied by cooperating institutions (e.g. the Department of Experimental Biology, the Department of Pharmacology or the Regional Centre for Applied Molecular Oncology). The analyzed compounds include selected drugs or endogenous compounds (e.g. lipids, glycans).

Requirements:

Successful candidate must hold the equivalent of a Czech Master's degree (Mgr., Ing., MSc.) in the same or similar study programmes from an institution of recognized standing (four or five year undergraduate degree). Hands-on experience with MALDI MS and software skills (MATLAB, R) are welcomed.

Detailed information available at: http://ls-phd.ceitec.cz

Conditions and contact:

Starting date: September 2020

Complete applications can be submitted: until 20 February 2020

To apply please contact phd@ceitec.muni.cz

Information about CEITEC PhD School

  • 4-year program
  • Above-standard funding
  • State-of-the-art Core Facilities
  • International and interdisciplinary environment
  • Wide range of topics from experiences supervisors
  • Coursework in your chosen field, soft and transferable skills and bioinformatics

Information about Brno and Czech Republic

  • #4 most popular city in the world for students according to topuniversities.com
  • #1 best city for expat support according to Financial Times
  • The capital of South Moravian Region and the second largest city in the Czech Republic with a population of almost 400,000 people
  • A city of universities with more than 86,000 students
  • City of Gregor Mendel, the founder of genetics
  • #6 safest country according to whitepaper on the future of Europe
  • EU, Schengen, NATO, OECD member

Information about Masaryk University

  • The second largest university in the Czech Republic, consisting of nine faculties
  • Extremely wide range of study possibilities
  • State-of-the-art equipment, cutting-edge technologies and international cooperation

A member of the Compostela Group and the Utrecht Network

Start date: September 2020
Opened Until: 20.2.2020

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