Research Position | Published on 20.12.2019 |
Mass spectrometry imaging (MSI) exploits the ability of mass spectrometry to identify molecules according to their specific mass and image their distribution across the sample. The method allows direct visualization of endogenous compounds (lipids, proteins, small molecules) as well as exogenous drugs and their metabolites.
Supervisor: Jan Preisler
The aim of the research will be development of a suitable matrix-assisted laser desorption/ionization (MALDI) MSI method for the study of distribution and the effect of chosen drug selected tissues and cell lines. Special attention will be devoted to sample preparation and matrix deposition (spray, sublimation, piezoelectric dispenser) and data processing. The samples will be supplied by cooperating institutions (e.g. the Department of Experimental Biology, the Department of Pharmacology or the Regional Centre for Applied Molecular Oncology). The analyzed compounds include selected drugs or endogenous compounds (e.g. lipids, glycans).
Successful candidate must hold the equivalent of a Czech Master's degree (Mgr., Ing., MSc.) in the same or similar study programmes from an institution of recognized standing (four or five year undergraduate degree). Hands-on experience with MALDI MS and software skills (MATLAB, R) are welcomed.
Detailed information available at: http://ls-phd.ceitec.cz
Conditions and contact:
Starting date: September 2020
Complete applications can be submitted: until 20 February 2020
To apply please contact firstname.lastname@example.org
Information about CEITEC PhD School
Information about Brno and Czech Republic
Information about Masaryk University
Start date: September 2020
Opened Until: 20.2.2020