Research Position | Published on 03.02.2020 |
Supervisor: Gabriel Demo
OBJECTIVES: The research aims to unravel the fundamental mechanism of the transcription-translation coupling in bacteria. These studies will significantly advance the current understanding how the lead ribosome closely trails the RNA polymerase (RNAP), thus promoting pause-free transcription, mRNA quality and efficient gene expression in bacteria.
FOCUS: Doctoral research projects focus on the mechanistic details and functional outcomes of coupled transcription-translation in bacteria. Students benefit from the shared cutting-edge core facilities of CEITEC that include (i) X-ray crystallography – crystallization robot Mosquito, Rigaku crystal hotel and diffraction system, (ii) cryo-EM equipment - Versa 3D dual beam microscope, Titan Krios and F20 electron microscopes (iii) High-field NMR systems, and (iv) biomolecular interactions equipment - confocal microscopes, near-field optical microscope (SNOM), surface plasmon resonance, microcalorimetric equipment.
Open PhD Positions:
We are seeking a Ph.D. candidate who holds MSc. in molecular biology or biochemistry and run the biochemical assays, or who was trained in structural biology, mainly single-particle cryo-EM or cryo-electron tomography (cryo-ET). The candidate should be able to purify the components for structural studies of transcription-translation coupling and run the biochemical assays. The candidate should be a motivated person with collaborative mindset.
Detailed information available at: http://ls-phd.ceitec.cz
Conditions and contact:
Starting date: September 2020
Complete applications can be submitted: until 24 February 2020
To apply please contact email@example.com
Information about CEITEC PhD School
Information about Brno and Czech Republic
Information about Masaryk University
A member of the Compostela Group
Start date: September 2020
Opened Until: 24.2.2020