Research Position | Published on 27.05.2020 |
We are looking for a motivated Post-Doc for a project funded by ERC Grant (Marek Mraz lab, www.ceitec.cz/mrazlab).
The project goal is to understand the role of noncoding RNAs in the regulation of microenvironmental interactions in B cell malignancies. The lab is deciphering novel mechanisms of BCR signaling regulation mediated by microenvironmental signals, CD20, p53, and the signals from T cells (Pavlasova et al. Blood, 2016; Pavlasova et al. Leukemia, 2018). We showed for the first time that non-coding RNAs, namely microRNAs (miRNAs), regulate the BCR signaling which opened an interesting field of research (Musilova et al. Blood, 2018; Mraz et al. Blood, 2014; Cerna et al. Leukemia, 2018). Now we would like to reveal the role of lncRNAs in BCR signaling and other microenvironmental interactions of leukemias.
We have identified candidate long-noncoding RNAs (lncRNAs) that might act as novel regulators of the crosstalk of BCR signaling/T-cell interactions/adhesion in B cell malignancies. This will be further investigated by the post-doctoral researcher using technics such as genome editing (CRISPRi), RNA sequencing, functional studies with various in vitro (primary cells and cell lines), and in vivo models. The research is also relevant for pre-clinical development of novel RNA-based therapeutic trials, and resistance mechanisms to BCR inhibitors.
WHAT DO WE OFFER:
OTHER INFO: The research is funded by ERC Starting grant, and will be conducted at CEITEC MASARYK UNIVERSITY. Our laboratory extensively collaborates with the University Hospital Brno in the same campus to obtain primary samples from patients. The campus provides a vibrant, multidisciplinary, and highly collaborative scientific environment. The lab is located in Brno, the second-largest city in Czech Republic that has the biggest concentration of biomedical research in the region. Brno is one of the major cultural hubs, with a vibrant and lively atmosphere housing ~60.000 students. The city has a very good public transport and plenty of interesting places to visit within the reach of trains (within a small distance of several major cities such as Prague, Vienna, Bratislava, Budapest) and close to international airports.
Start date: Negotiable
Opened Until: 31.8.2020