POST-DOC POSITION: REGULATION OF CELL MIGRATION IN B CELL LEUKEMIAS AND LYMPHOMAS

Research Position | Published on 27.05.2020 | CEITEC MU

POST-DOC POSITION: REGULATION OF CELL MIGRATION IN B CELL LEUKEMIAS AND LYMPHOMAS

CEITEC is a scientific centre in the fields of life sciences, advanced materials and technologies whose aim is to establish itself as a recognized centre for basic as well as applied research. CEITEC offers a state-of-the-art infrastructure and great conditions to employ excellent researchers.

Our institute values diversity and promotes an inclusive working environment with the aim to support the best scientists. CEITEC MU is a proud holder of the HR Excellence in Research Award by the European Commission (http://muni.ceitec.cz/en/hr-strategy-hrs4r/).

We are looking for a motivated Post-Doc for a project funded by ERC Grant (Marek Mraz lab, www.ceitec.cz/mrazlab).

            The project goal is to understand the molecular machinery that regulates the migration of malignant B cells between different niches such as lymphoid and bone marrow niche and peripheral blood. This is of great interest, especially in chronic lymphocytic leukemia (CLL). In CLL, but also in other lymphomas, the malignant B cells permanently re-circulate from peripheral blood to lymph nodes and back, and blocking this recirculation can be used therapeutically since malignant B cell depent on signals in immune microenvironment. However, the factors that regulate this are mostly unclear. The lab established several models for in vitro and in vivo studies of microenvironmental interactions and their interplay (unpublished in vivo model; Pavlasova et al. Blood, 2016; Pavlasova et al. Leukemia, 2018; Musilova et al. Blood, 2018; Mraz et al. Blood, 2014; Cerna et al. Leukemia, 2018).

            We have identified candidate molecules that might act as novel regulators of the B cell migration or the balance between homing and survival in peripheral blood. This will be further investigated by the post-doctoral researcher using technics such as genome editing (CRISPR), RNA sequencing, use of primary smaples, functional studies with various in vitro and in vivo models. The research is also relevant for understanding resistance mechanisms to BCR inhibitors, pre-clinical development of novel drugs and their combinations (several patents submitted by the lab).

 

WHAT DO WE OFFER:

project funded by the prestigious ERC grant = high risk and high gain, state-of-the-art instruments, stable funding, a competitive salary, collaboration with top experts in the field

You will work in a team of young investigators that challenge some long-standing problems in hematology (we have access to a large biobank of primary samples).

Interesting position in a dynamically expanding research institute

An attractive salary and benefits package (6 weeks of paid holiday, meal tickets, MU canteens, retirement contribution)

Background of a recognized and successful institution with supportive and international working environment

Environment promoting interdisciplinarity and intersectorality of research

In house core facilities

Support of administrative departments (including grant office service)

Support with the relocation process (welcome office service)

CEITEC, Brno, Czech Republic (http://www.ceitec.eu) is a newly established European research center of scientific excellence.

YOUR PROFILE:

Motivated smart people that have the “drive” to work independently, but also willing to learn from other people in the lab and collaborate.

Candidates should have PhD degree (or expected within 3 months of applying) in Molecular biology, Oncology, Biochemistry, or similar field.

The Post-Doc position is for 2-4 years. Post-Doc position will start in 2020 (negotiable). Apply as soon as possible.

The position is NOT associated with any teaching obligations.

We welcome applications from all national (Czech) and international applicants.

 

TO APPLY:

To apply please send CV with two references and a full list of publications to the PI Marek Mraz: marek.mraz@email.cz  (Subject: Post-Doc position).

Information about the laboratory at: http://mrazlab.ceitec.cz/positions.html

OTHER INFO:

The research is funded by ERC Starting grant, and will be conducted at CEITEC MASARYK UNIVERSITY. Our laboratory extensively collaborates with the University Hospital Brno in the same campus to obtain primary samples from patients. The campus provides a vibrant, multidisciplinary, and highly collaborative scientific environment. The lab is located in Brno, the second-largest city in Czech Republic that has the biggest concentration of biomedical research in the region. Brno is one of the major cultural hubs, with a vibrant and lively atmosphere housing ~60.000 students. The city has a very good public transport and plenty of interesting places to visit within the reach of trains (within a small distance of several major cities such as Prague, Vienna, Bratislava, Budapest) and close to international airports.

Information about Brno, Czech Republic

The capital of South Moravian Region and the second largest city in the Czech Republic with a population of almost 400,000 people

Modern, dynamic and fast growing centre of industry, trade, science, research  and innovation with business incubators and centres of excellence in science

A city of universities with more than 86,000 students

More than 10,000 researchers; 2,200 IF publications/year; 600+ PhD graduates/year

500 mil. EUR of R&D investment per year, more than 350 companies with in-house R&D

City of Gregor Mendel, the founder of genetics; the prestigious Mendel Lectures series takes place in Brno since 2003 (lectures of the world´s top scientists, including Nobel Prize winners)

Quality of life index in 2016

 

Further info

CEITEC, please visit www.ceitec.eu

CEITEC Welcome Office, please visit https://www.ceitec.eu/welcome-office/t9938

Masaryk University, please visit www.muni.cz

Brno, please visit http://www2.brno.cz/index.php?lan=en&nav01=20608&nav02=20617

Start date: Negotiable
Opened Until: 31.12.2020

I am interested
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