Research Position | Published on 11.12.2019 |
The Director of Central European Institute of Technology
(CEITEC MU) opens a Postdoc position
Role of Specific protein-protein interactions in the formation of protein liquid droplets
Description of project
Cells employ protein liquid droplets to form dynamic clusters, which function as nanoreactors or storages with the increased local concentration of specific protein components. These membrane-less organelles self-assemble based on weak protein-protein interactions of intrinsically disordered domains. However, the role of specific sequences remains elusive and the mixing between different protein droplets unexplored. This project is focused on the droplets involved in genome transcription, where posttranslational modifications control the droplet composition and regulate the transcription. Expected findings are not only important for the general knowledge but could also be useful in the design of new treatments because translocation malfunction is involved in numerous diseases including cancer. The research is strongly coupled to collaborations with excellent experimental teams and will be more closely discussed during the interview. The employed tools will contain multi-scale simulations using a wide range of advanced sampling techniques and development of protein parametrization.
CEITEC is a scientific centre in the fields of life sciences, advanced materials and technologies whose aim is to establish itself as a recognized centre for basic as well as applied research. CEITEC offers a state-of-the-art infrastructure and great conditions to employ excellent researchers. Our institute values diversity and promotes an inclusive working environment with the aim to support the best scientists. CEITEC MU is a proud holder of the HR Excellence in Research Award by the European Commission. (http://muni.ceitec.cz/en/hr-strategy-hrs4r/)
A postdoc position is available in the Robert Vácha lab (vacha.ceitec.cz; CEITEC, Masaryk University, Brno, Czech Republic) to participate in research focused on computer simulations of intrinsically disordered proteins and their liquid-liquid phase separation. We are seeking a person with expertise in computer simulations of proteins or polymers and experience with coarse-grained models. Research will be conducted at CEITEC located in the life science campus of Masaryk University (Brno, Bohunice, https://www.ceitec.eu/).
Anticipated start date: Negotiable
The application should include:
Applications should be sent by e-mail to email@example.com.
Please quote the “Postdoc - liquid droplets” in the subject.
Electronic application deadline is: 29th February 2020
Information about Brno, Czech Republic
For further information about:
Start date: negotiable
Opened Until: 29.2.2020