Contact
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| Phone: | +420 54949 5460 |
| Research group: | ERA Chair - RNA and Immunity - Mary O´Connell |
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24. Aug. 2020
Vědci z CEITEC odhalili důležité souvislosti vzácné formy epilepsie
Mezinárodní tým vědců, včetně Jiřího Sedmíka a Liama Keegana, pod vedením profesorky Mary O´Connellové z CEITEC Masarykovy univerzity, dokázal, jak…
8. July 2020
Karel Riha From CEITEC Was Elected as a New EMBO Member
Press release The prestigious European Molecular Biology Organisation, EMBO, based in Heidelberg (Germany) has officially announced the names of its…
7. July 2020
Researcher Contracts Under Strain as Economic Recession Looms
Covid-19 worsens the already precarious scenario for scientists on short-term contracts. In the midst of the coronavirus pandemic, the need for…
29. June 2020
MSCA ITN – A Unique Opportunity for Prospective PhD Students
Press Release The Mary O’Connell RNA and Immunity Research Group at CEITEC Masaryk University will take part in a three-year MSCA ITN project, along…
21. May 2020
Čeští vědci si připsali objev neznámé části RNA
Pomocí metod chemické biologie se odborníkům otevírají možnosti výzkumu nových RNA modifikací zejména ve virech a bakteriích, díky čemuž je usnadněno…
17. Apr. 2020
Scientists From CEITEC Revealed the Role of ADAR RNA Editing in Neurogeneration and Immunity
In an international collaboration between two research teams, scientists, including Anzer Khan from CEITEC Masaryk University and Patricia Deng from…
30. Mar. 2020
Researchers From CEITEC Found Important Links Behind Rare Neurological Disease
An international team of researchers including Jiri Sedmik and Liam Keegan, led by Research Group Leader Mary O´Connell from CEITEC Masaryk…
11. Feb. 2020
International Day of Women and Girls in Science 2020
As we celebrate the International Day of Women and Girls in Science on 11 February 2020, we are reminded of the need to honour the contribution of…
22. Jan. 2020
Interview with Prof. Mary O’Connell – ERA Chair: How is ERA Chair changing the Czech research environment?
Interview with Professor Mary O'Connell focuses on the ERA Chair (H2020 SEWP) to support universities and research institutes in attracting and…
26. Sept. 2019
PI Seminars Connect Research Teams with Students
Každý pátek po celý semestr hostí kampus semináře, které mají bořit bariéry mezi laboratořemi i mezi vědci a studenty. Provázat výzkumné…
13. Sept. 2019
People Are the Most Valuable Resources at CEITEC. Find out More About Mary O'Connell´s and Zdenek Farka´s Research
The most valuable resources at CEITEC are scientists and experts who have the knowledge and skills to work with unique devices. Two reports …
1. July 2019
In conversation with Mary O’Connell: an Irish scientist in Brno
Prof. Mary O’Connell, the group leader of the research group RNA and Immunity at CEITEC, discusses her scientific voyage across borders and cultures,…
12. June 2019
A molecular biologist of CEITEC MU among the world leaders in her field
Štěpánka Vaňáčová of CEITEC Institute at Masaryk University has been elected a member of the highly reputable European Molecular Biology Organization…
30. Apr. 2019
The rising profile of CEITEC
An EU venture is helping to upgrade a Czech university and the association of organisations in which it is a key participant. Founded in 1919 in…
16. Apr. 2018
Interview with Mary O´Connell for The RNA Society: You will have your ups-and-downs…
Mary O'Connell, a member of The RNA Society and group leader of the research group ERA Chair - RNA and Immunity at CEITEC, provided an interview…
21. June 2017
A scientist from MU has become a member of a prestigious molecular biology organization
Mary O'Connell, CEITEC MU, was recently elected a member of the European Molecular Biology Organization (EMBO). A recognised scientist Mary O…
9. June 2017
ERA CHAIR Conference – Nucleid Acids and Immunity 2017 is over
The organizers of the second conference on Nucleic Acids and Immunity; Mary O´Connell and Liam Keegan are very happy with the success of the conference. The conference hosted over one hundred participants with approximately twenty…
Publications that are part of the Web of Science database, possibly also other publications chosen by authors.
2020
- Deng, P; Khan, A; Jacobson, D; Sambrani, N; McGurk, L; Li, XH; Jayasree, A; Hejatko, J; Shohat-Ophir, G; O´Connell, MA; Li, JB; Keegan, LP, 2020: Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila. NATURE COMMUNICATIONS 11(1), doi: 10.1038/s41467-020-15435-1
- Tan, TY; Sedmik, J; Fitzgerald, MP; Halevy, RS; Keegan, LP; Helbig, I; Basel-Salmon, L; Cohen, L; Straussberg, R; Chung, WK; Helal, M; Maroofian, R; Houlden, H; Juusola, J; Sadedin, S; Pais, L; Howell, KB; White, SM; Christodoulou, J; O´Connell, MA, 2020: Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures. AMERICAN JOURNAL OF HUMAN GENETICS 106(4), p. 467 - 483, doi: 10.1016/j.ajhg.2020.02.015
- Khan, A; Paro, S; McGurk, L; Sambrani, N; Hogg, MC; Brindle, J; Pennetta, G; Keegan, LP; O´Connell, MA, 2020: Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy. BMC BIOLOGY 18(1), doi: 10.1186/s12915-020-0747-0
2019
- Wiatrek, DM; Candela, ME; Sedmik, JI; Oppelt, J; Keegan, LP; O´Connell, MA, 2019: Activation of innate immunity by mitochondrial dsRNA in mouse cells lacking p53 protein. RNA 25(6), p. 713 - 726, doi: 10.1261/rna.069625.118
- Sinigaglia, K; Wiatrek, D; Khan, A; Michalik, D; Sambrani, N; Sedmik, J; Vukic, D; O´Connell, MA; Keegan, LP, 2019: ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1862(3), p. 356 - 369, doi: 10.1016/j.bbagrm.2018.10.011
- Bass, BL; O´Connell, MA; Wagner, EGH, 2019: A celebration of the life of Marie Ohman (1964-2019). RNA 25(10), p. IX - XI, doi: 10.1261/rna.072645.119
2018
- O´Connell, M; Khan, A; Sambrani, N; Novakova, B; Keegan, L, 2018: Deciphering a novel role of ADAR in Drosophila development. FEBS OPEN BIO 8, p. 14 - 14
- Jantsch, MF; Quattrone, A; O´Connell, M; Helm, M; Frye, M; Macias-Gonzales, M; Ohman, M; Ameres, S; Willems, L; Fuks, F; Oulas, A; Vanacova, S; Nielsen, H; Bousquet-Antonelli, C; Motorin, Y; Roignant, JY; Balatsos, N; Dinnyes, A; Baranov, P; Kelly, V; Lamm, A; Rechavi, G; Pelizzola, M; Liepins, J; Kholodnyuk, IH; Zammit, V; Ayers, D; Drablos, F; Dahl, JA; Bujnicki, J; Jeronimo, C; Almeida, R; Neagu, M; Costache, M; Bankovic, J; Banovic, B; Kyselovic, J; Valor, LM; Selbert, S; Pir, P; Demircan, T; Cowling, V; Schafer, M; Rossmanith, W; Lafontaine, D; David, A; Carre, C; Lyko, F; Schaffrath, R; Schwartz, S; Verdel, A; Klungland, A; Purta, E; Timotijevic, G; Cardona, F; Davalos, A; Ballana, E; O´Carroll, D; Ule, J; Fray, R, 2018: Positioning Europe for the EPITRANSCRIPTOMICS challenge. RNA BIOLOGY 15(6), p. 829 - 831, doi: 10.1080/15476286.2018.1460996
2017
- Keegan, L; Khan, A; Vukic, D; O´Connell, M, 2017: ADAR RNA editing below the backbone. RNA 23(9), p. 1317 - 1328, doi: 10.1261/rna.060921
- Tan, MH; Li, Q; Shanmugam, R; Piskol, R; Kohler, J; Young, AN; Liu, KI; Zhang, R; Amaswami, GR; Ariyoshi, K; Gupte, A; Keegan, LP; George, CX; Amu, AR; Huang, N; Pollina, EA; Leeman, DS; Ustighi, AR; Goh, YPS; Hawla, AC; Del Sal, G; Peltz, G; Runet, AB; Onrad, DFC; Samuel, CE; O´Connell, MA; Walkley, CR; Nishikura, K; Li, JB, 2017: Dynamic landscape and regulation of RNA editing in mammals. NATURE 550(7675), p. 249 - +, doi: 10.1038/nature24041
- Gallo, A; Vukic, D; Michalik, D; O´Connell, MA; Keegan, LP, 2017: ADAR RNA editing in human disease; more to it than meets the I. HUMAN GENETICS 136(9), p. 1265 - 1278, doi: 10.1007/s00439-017-1837-0
- Quin, JE; Bujila, I; Cherif, M; Sanou, GS; Qu, Y; Homann, MV; Rolicka, A; Sirima, SB; O´Connell, MA; Lennartsson, A; Troye-Blomberg, M; Nebie, I; Farrant, AKO, 2017: Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria. ELIFE 6, doi: 10.7554/eLife.29156
- Bajad, P; Jantsch, MF; Keegan, L; O´Connell, M, 2017: A to I editing in disease is not fake news. RNA BIOLOGY 14(9), p. 1223 - 1231, doi: 10.1080/15476286.2017.1306173
2015
- O´Connell, M, 2015: RNA modification and the epitranscriptome; the next frontier. RNA 21(4), p. 703 - 704, doi: 10.1261/rna.050260.115
- Mannion, N; Arieti, F; Gallo, A; Keegan, LP; O´Connell, MA, 2015: New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins. BIOMOLECULES 5(4), p. 2338 - 2362, doi: 10.3390/biom5042338
- M. A. O’Connell; N. Mannion; L.P. Keegan, 2015: The Epitranscriptome and Innate Immunity. PLOS GENETICS 12(11), doi: 10.1371/journal.pgen.1005687
2014
- Mannion, NM; Greenwood, SM; Young, R; Cox, S; Brindle, J; Read, D; Nellaker, C; Vesely, C; Ponting, CP; McLaughlin, PJ; Jantsch, MF; Dorin, J; Adams, IR; Scadden, ADJ; Ohman, M; Keegan, LP; O´Connell, MA, 2014: The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA. CELL REPORTS 9(4), p. 1482 - 1494, doi: 10.1016/j.celrep.2014.10.041
2013
- Ramaswami, G; Zhang, R; Piskol, R; Keegan, LP; Deng, P; O´Connell, MA; Li, JB, 2013: Identifying RNA editing sites using RNA sequencing data alone. NATURE METHODS 10(2), p. 128 - 132, doi: 10.1038/NMETH.2330
2012
- Rice, GI; Kasher, PR; Forte, GMA; Mannion, NM; Greenwood, SM; Szynkiewicz, M; Dickerson, JE; Bhaskar, SS; Zampini, M; Briggs, TA; Jenkinson, EM; Bacino, CA; Battini, R; Bertini, E; Brogan, PA; Brueton, LA; Carpanelli, M; De Laet, C; de Lonlay, P; del Toro; Keegan, LP; O´Connell, MA; Lovell, SC; Crow, YJ, 2012: Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature. NATURE GENETICS 44(11), p. 1243 - 1248, doi: 10.1038/ng.2414
2011
- Marcucci, R; Brindle, J; Paro, S; Casadio, A; Hempel, S; Morrice, N; Bisso, A; Keegan, LP; Del Sal, G; O´Connell, MA, 2011: Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects. EMBO JOURNAL 30(20), p. 4211 - 4222, doi: 10.1038/emboj.2011.303
2010
- Galeano, F; Leroy, A; Rossetti, C; Gromova, I; Gautier, P; Keegan, LP; Massimi, L; Di Rocco, C; O´Connell, MA; Gallo, A, 2010: Human BLCAP transcript: new editing events in normal and cancerous tissues. INTERNATIONAL JOURNAL OF CANCER 127(1), p. 127 - 137, doi: 10.1002/ijc.25022
2009
- Heale, BSE; Keegan, LP; McGurk, L; Michlewski, G; Brindle, J; Stanton, CM; Caceres, JF; O´Connell, MA, 2009: Editing independent effects of ADARs on the miRNA/siRNA pathways. EMBO JOURNAL 28(20), p. 3145 - 3156, doi: 10.1038/sj.emboj.2009.244
- ADAR RNA editing; how immune systems and brains breach The Central Dogma, Grantová agentura ČR, 2021 - 2025
- ADAR RNA editing; how immune systems and brains breach The Central Dogma, Grantová agentura ČR, 2021 - 2025
- ROles of ePitranscriptomic in diseasES, , 2020 - 2024
- Integration of RNA Biology for Next-Generation Scientists, , 2021 - 2023
- Elucidating the role of the RNA editing enzyme ADAR1 in novel biological pathways and determine its posttranslational regulation., Grantová agentura ČR, 2020 - 2022
- Generation of stable cell lines for the screening of inhibitors of the ADAR enzymes, Masarykova univerzita, 2020 - 2021