Structural Biology of Gene Regulation

ABOUT US

Structural Biology of Gene Regulation

Structural biology of gene regulation focuses on how cells control gene activity at the molecular level. It studies interactions between RNA and proteins that determine when and how genetic information is used. The field uses advanced structural, biochemical, and biophysical methods to understand how these molecular complexes function and how they influence fundamental cellular processes.

Our Publications

NUCLEIC ACIDS RESEARCH

Cooperation between intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly

Kasiliauskaite, A; Kubicek, K; Klumpler, T; Zanova, M; Zapletal, D; Koutna, E; Novacek, J; Stefl, R

doi: 10.1093/nar/gkac451

JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct mechanisms of recognition of phosphorylated RNAPII C-terminal domain by BRCT repeats of the BRCA1-BARD1 complex

Klapstova, V; Sedova, K; Houser, J; Sebesta, M

doi: 10.1016/j.jbc.2025.111010

STRUCTURE

Assembly of the Xrn2/Rat1-Rai1-Rtt103 termination complexes in mesophilic and thermophilic organisms

Dikunova, A; Noskova, N; Overbeck, JH; Polak, M; Stelzig, D; Zapletal, D; Kubicek, K; Novacek, J; Sprangers, R; Stefl, R

doi: 10.1016/j.str.2024.11.010

NUCLEIC ACIDS RESEARCH

Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks

Long, QL; Ajit, K; Sedova, K; Haluza, V; Stefl, R; Dokaneheifard, S; Beckedorff, F; Valencia, MG; Sebesta, M; Shiekhattar, R; Gullerova, M

doi: 10.1093/nar/gkae937