Medical Genomics

Medical genomics explores how genetic changes affect cell function and contribute to disease development. Thanks to advanced technologies, we can now analyse the human genome in great detail, identify the genetic causes of disease, and apply this knowledge to diagnostics and patient care.

Our Publications

ANNALS OF HEMATOLOGY

Assessment of long-read strategies for the enrichment of clinically relevant breakpoints in lymphomas: towards a diagnostic implementation

Pardy, F; Reblova, K; Svozilova, H; Tichy, B; Pospisilova, S; Kotaskova, J; Navrkalova, V

doi: 10.1007/s00277-026-06754-2

HEMASPHERE

Casein kinase 1δ/ε inhibition suppresses CLL proliferation through cell-intrinsic and microenvironmental mechanisms

Mikulova, A; Plesingerova, H; Chorvatova, M; Kebkova, P; Bartosikova, J; Prochazkova, P; Verner, J; Mulidran, D; Cada, S; Vondalova-Blanarova, O; Kolcakova, N; Loja, T; Kurucova, T; Hoferkova, E;…

doi: 10.1002/hem3.70343

BLOOD ADVANCES

Central nervous system involvement in CLL: an international retrospective study by ERIC, the European Research Initiative on CLL

Chatzikonstantinou, T; Mikhaleva, M; Brieghel, C; Papangelou, C; Minga, E; Arrais-Rodrigues, C; Besikli-Dimou, S; Cerutti, A; Doubek, M; Enggaard, L; Espinet, B; Ferrer-Lores, B; Vela, JAG; Gentile,…

doi: 10.1182/bloodadvances.2025017755

DIAGNOSTIC PATHOLOGY

Advanced NGS analysis of cell-free tumor DNA supports clonal relation to primary high-grade B-cell lymphoma lesion and CNS relapse despite MRI negativity

Navrkalova, V; Mareckova, A; Porc, J; Hricko, S; Hrabcakova, V; Kissova, J; Kundova, S; Jarosova, M; Pospisilova, S; Kotaskova, J; Janikova, A

doi: 10.1186/s13000-025-01609-2