Artificial Anion Transporters for Biomedical Application
23. May 2018
CEITEC MU scientists at the head of international team, Ondřej Jurček, as the first author, Martin Novák and Radek Marek, have recently published an article in Chemistry – A European Journal, in which they carried out detailed structural analysis of non-toxic anionophore of exceptional interest for biomedical applications and studied its interaction with a broad range of biogenic anions. This study highlights the preorganization conferred by the trans-1,5-diureidodecalin framework and helps to understand more of its properties and behaviour. This is important for further progress towards its practical use. A particular hope is that such artificial anion carriers can be used to replace the activity of natural anion channels (e.g. CFTR) which are missing or defective in a number of genetic disorders, most notably, the widespread life-shortening disease cystic fibrosis (CF). This article is a follow-up on a study published in Nature Chemistry (doi:10.1038/nchem.2384), where scientists, together with Ondřej, have introduced and studied the biological activity of this exceptional anionophore for the first time.
A great number of anion carriers, including this one, has been developed and studied in the laboratories of Prof. A. P. Davis from the University of Bristol, who will have a lecture within the Life Sciences Seminar Series on Thursday, 24th of May at 16:00 in A11/132.