Lecture Seminar Series

AMN SEMINAR SERIES 2019: Stem and niche cell interactions during development and regeneration

About event

Stem and niche cell interactions during development and regeneration

Regulation of skeletal muscle stem cells during homeostasis and regeneration involves the interplay between extrinsic and intrinsic cues. The mechanisms by which niche molecules and intrinsic factors regulate muscle stem cell quiescence and properties remain largely unknown. In a series of studies, we investigated Notch as a key mediator of muscle stem cell stability and fate through extrinsic regulation of extracellular matrix, and internal regulation of cell migration via the mirtron mir708. Using static and live imaging, these observations led us to propose a two-step mechanism where the final mitosis before cellular quiescence and cell migration need to be independently regulated prior to niche occupancy by the stem cell.

Dr. Shahragim Tajbakhsh's CV.

Date

29. 10. 2019, 10:00 - 11:00
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Speaker

Dr. Shahragim Tajbakhsh
Stem Cells & Development Unit, UMR CNRS 3738, Institut Pasteur, Paris, France

Venue

CEITEC BUT, Large meeting room (building S)