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Biomolecular condensates in plant germline differentiation
- Project type: GACR EXPRO
- Project coordinator: CEITEC MU
- Project code: GX23-07969X
- Implementation period: 01.01.2023 – 31.12.2027
- Total budget:
- Budget for CEITEC MU:
Project description:
Biomolecular condensates are membrane-less compartments that concentrate proteins and nucleic acids via multivalent interactions, and exhibit features of liquid-liquid phase separation. They have been implicated in number of cellular processes and list of their biological functions has rapidly grown over recent years. P-bodies are cytoplasmic condensates involved in translation repression, RNA storage and RNA decay, but how these opposite outcomes are achieved is not resolved. P-bodies are also important for differentiation of plant germline. We showed that P-bodies change composition and functional properties in the course of Arabidopsis meiosis, which represents unique system to study mechanisms of their action and regulation. In this application we propose to combine quantitative imaging and genomic approaches to study the function of P-bodies in plant meiosis. Gained knowledge will fundamentally advance our understanding of gene regulation in plant germline, and proposed technological developments will contribute to research on biomolecular condensates in plants.
Principal investigator:
