Daniel Zicha

Daniel Zicha

Senior researcher


Phone: +420 54114 2778
Research group: Experimental Biophotonics - Radim Chmelík

Daniel Zicha received his MSc from the Czech University of Technology, Prague with thesis on “Expert system for genetic diagnosis”. He then pursued a PhD project on “Artificial intelligence methods in tumour cell biology” at the Institute of Molecular Genetics, Czech Academy of Sciences. His subsequent postdoctoral research post, focussing on chemotaxis [Zicha, D. et al. (1991) A new direct viewing chemotaxis chamber. J Cell Sci 99 769-75] and development of interference microscopy [Dunn, G. A., and Zicha, D. (1997) Using the DRIMAPS system of interference microscopy to study cell behavior. In Handbook of Cell Biology (2nd edition), J. E. Celis (ed.), Academic Press Inc.], was held at Medical Research Council, Muscle and Cell Motility Unit, King's College, London, UK. Daniel Zicha has been head of Light Microscopy at Imperial Cancer Research Fund/ Cancer Research UK London Research Institute/ the Francis Crick Institute, Lincoln's Inn Fields Laboratory for over 17 years and since 2016, senior researcher at Brno University of Technology, CEITEC - Central European Institute of Technology, Czech Republic. He has been involved in development of novel quantitative light microscopy techniques such as “Fluorescence Localisation After Photobleaching” [Zicha, D. et al. (2003) Rapid actin transport during cell protrusion. Science 300 142 5] and has experience with metastasis research [Cavanna, T., Pokorná, E., Veselý, P., Gray, C., and Zicha, D. (2007) Evidence for protein 4.1B acting as a metastasis suppressor. J Cell Sci 120 606-16]. Daniel Zicha has been a member of the editorial board of the Journal of Microscopy since 2007.


  • Image reconstruction of three-dimensional objects by the methods of the holographic confocal microscopy (GA202/04/1410), Czech Science Foundation - Standard Grants, 2004 - 2006
  • Inorganic nanomaterials and nanostructures: fabrication, characterization, properties (MSM0021630508), MEYS - Institutional Research Plan, 2005 - 2011
  • The significance of fast intracellular motile reactions in living cells (GA304/99/0368), Czech Science Foundation - Standard Grants, 1999 - 2001
  • Validation of digital holographic microscope in investigations of living cell dynamics & completion of new multifunctional instrument (GA202/08/0590), Czech Science Foundation - Standard Grants, 2008 - 2010
  • Advances incoherent holographic microscopy using photonic simulations and principles of singular optics (GA15-14612S), Czech Science Foundation - Standard Grants, 2015 - 2017
  • Progress in quantitative phase imaging achieved with cutting-edge technologies for transformation of geometric phase of light (TA622S01001), Technology Agency of the Czech Republic, 2018 - 2020
  • Center of digital optics (GA628S00000), Czech Science Foundation - Standard Grants, 2012 - 2019