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Mechanisms of RNA biogenesis regulated by RNA modifying factors
Doctoral study program
Life Sciences (Faculty of Science, Masaryk University)
Supervisor
Prof. Štěpánka Vaňáčová, Ph.D.
Annotation
Posttranscriptional RNA modifications possess key roles in diverse pathways in humans, including development, disease and infections. This PhD project will focus on the machines and role of internal RNA modifications of coding and noncoding RNAs in human cells. The student will master diverse methodologies, such as human cell culture manipulations (cultivation, RNAi, CRISPR/Cas9, etc.), recombinant DNA preparation, protein expression and purification, high-throughput analyses and enzymatic assays. She/he will have the opportunity to present the results at prestigious international conferences. Moreover, this project will involve collaboration with other leading researches in European institutes.
Funding of the PhD candidate
OP JAK – RNA for Therapy
Requirements for candidate
Prospective student should ideally have done master degree in molecular biology/biochemistry and have a laboratory experience in nucleic acids and/or protein purification and analyses. Experience with coding in R and statistics is a big plus. The most highly valued feature however is excitement and curiosity for science and strong drive in tackling important biological questions.