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If you would like to participate online, please contact us at events@ceitec.muni.cz. Online participation is not possible on a one-time basis. It is intended for students whose health and other conditions prevent them from attending on-site during the semester.
Oncogenic signaling pathways are intricately regulated networks where alterations can lead to malignant transformation but also provide opportunities for targeted interventions. In the case of malignant melanoma, the aggressive growth of cancer cells is driven by BRAF and NRAS oncogenic mutations that overactivate the ERK mitogen-activated protein kinase (MAPK) signaling pathway. In my talk, I will introduce the concept of MAPK fitness zone and describe a novel signaling axis essential for controlling ERK MAPK signaling in melanoma.
