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Eukaryotic gene expression is a multistep process involving transcription, mRNA processing, and translation, each regulated at multiple levels. Our lab investigates the roles of cyclin-dependent kinases (CDKs) in these processes. In this seminar, we will present our latest findings on how specific CDKs contribute to the regulation of pre-mRNA processing. We will also discuss how dysregulation of these pathways may contribute to the development of human diseases.