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About the research project:
One of the key reasons we are interested in biomaterials and tissue engineering is their ability to mimic the natural environment of cells and influence their behaviour. Since a single material often does not provide optimal conditions, scaffolds with precisely designed structures, such as hydrogels or porous foams, are used to control both internal architecture and mechanical properties. These features allow materials to guide cell growth and support the formation of functional tissue. In this topic, we will prepare two types of scaffolds, hydrogel-based and foam-based, from natural polymers. First, we will focus on the preparation of a hydrogel and its processing via 3D printing, which allows precise control over the shape and internal structure of the scaffold. In parallel, we will prepare foams using lyophilization, a freeze-drying process that creates a highly porous structure. Subsequently, we will study the properties of both scaffold types using optical microscopy and scanning electron microscopy (SEM), along with the evaluation of their swelling behaviour and degradation. These results will help us assess whether the prepared scaffolds are suitable for effective cell cultivation.
Research project outline:
- Introduction to biomaterials, tissue engineering, scaffolds, and their role in cell cultivation
- Preparation of hydrogel substrates and 3D printing of hydrogel-based scaffolds for medical applications
- Preparation of foam-based scaffolds using lyophilization (freeze-drying) to obtain highly porous materials
- Characterization of scaffolds using optical microscopy and scanning electron microscopy (SEM), together with evaluation of their swelling behaviour and degradation
- Evaluation of scaffold properties and its suitability for cell cultivation and potential to support cell growth
Capacity:
- 4 students
Research project leader:
