Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides

JOURNAL OF MEDICINAL CHEMISTRY

Khirsariya, P; Pospisil, P; Maier, L; Boudny, M; Babas, M; Kroutil, O; Mraz, M; Vacha, R; Paruch, K, 2022: Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides. JOURNAL OF MEDICINAL CHEMISTRY 65(7), p. 5701 - 5723, doi: 10.1021/acs.jmedchem.1c02228

Research Groups:

Microenvironment of Immune Cells
Interaction Protein-Protein and Protein-Membrane

CEITEC authors:

Miroslav Boudný, Ph.D.
Ondřej Kroutil, Ph.D.
Prof. Marek Mráz, Ph.D.
Prof. Robert Vácha, Ph.D.