About event
You are cordially invited to the seminar The RNA Polymerase-Ribosome Dance: Is It Hip Hop or Ballroom in Bacteria?
Protein translation in bacteria is the focus of Dr. Blaha’s research. He was introduced to this dynamic research field during his Ph.D. training at the Max Planck Institute for Molecular Genetics, Berlin, Germany. He continued to broaden his understanding of translation under the guidance of Nobel laureate Thomas Steitz at Yale University, where he determined the structure of several ribosome complexes, e.g., Blaha et al. Science 2009. This work rekindled a broader interest in translation factor EF-P and its eukaryotic homologue, eIF-5A, leading to the discovery that the translation of poly-proline stretches require the assistance of this factor. Since joining University of California, Riverside, Dr. Blaha’s research has expanded beyond protein translation to include transcription. Dr. Blaha is most recognized for his work on ribosome-RNA polymerase interactions which has transformed our understanding and reignited interest in the coupling of transcription and translation in bacteria.
Abstract:
The absence of a nuclear membrane in bacteria allows the RNA to be translated while being transcribed. Here, Dr. Blaha will present data from his laboratory that suggests that the concurrence of both processes on the same RNA results in a dynamic interplay between RNA polymerase and ribosome, a dance set to the music of the genetic information flowing from DNA to RNA to protein.
