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Home About Us People Václav Šeda, Ph.D.

Václav Šeda, Ph.D.

Václav Šeda, Ph.D.

Junior Staff Scientist


Publications that are part of the Web of Science database, possibly also other publications chosen by authors.
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Showing 16 out of total 16 records.

2024

LEUKEMIA Open access

Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs

HOFERKOVA, E.; SEDA, V.; KADAKOVA, S.; VERNER, J.; LOJA, T.; MATULOVA, K.; FRANCOVA, HS.; ONDROUSKOVA, E.; FILIP, D.; BLAVET, N.; BOUDNY, M.; PAVLASOVA, GM.; VECERA, J.; ONDRISOVA, L.; PAVELKOVA, P.; ...

doi: 10.1038/s41375-024-02284-w

2021

BLOOD Open access

miR-29 modulates CD40 signaling in chronic lymphocytic leukemia by targeting TRAF4: an axis affected by BCR inhibitors

Sharma, S; Pavlasova, GM; Seda, V; Cerna, KA; Vojackova, E; Filip, D; Ondrisova, L; Sandova, V; Kostalova, L; Zeni, PF; Borsky, M; Oppelt, J; Liskova, K; Kren, L; Janikova, A; Pospisilova, S; Fernande...

doi: 10.1182/blood.2020005627

BLOOD Open access

FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia

ŠEDA, V.; VOJÁČKOVÁ, E.; ONDRIŠOVÁ, L.; KOŠŤÁLOVÁ, L.; SHARMA, S.; LOJA, T.; MLADONICKÁ PAVLASOVÁ, G.; ZICHA, D.; PEŠKOVÁ, M.; KŘIVÁNEK, J.; LIŠKOVÁ, K.; KŘEN, L.; BENEŠ, V.; MUSILOVÁ LITZMANOVÁ, K.; ...

doi: 10.1182/blood.2020008101

HAEMATOLOGICA Open access

IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3K delta inhibitor idelalisib

Sandova, V; Pavlasova, GM; Seda, V; Cerna, KA; Sharma, S; Palusova, V; Brychtova, Y; Pospisilova, S; Fernandes, SM; Panovska, A; Doubek, M; Davids, MS; Brown, JR; Mayer, J; Mraz, M

doi: 10.3324/haematol.2021.278644

2019

Leukemia

MicroRNA miR-34a downregulates FOXP1 during DNA damage response to limit BCR signalling in chronic lymphocytic leukaemia B cells

Cerna, K; Oppelt, J; Musilova, K; Seda, V;Pavlasova, K; Radova, L; Arigoni, M; Calogero, RA; Benes, V; Tbusek, M; Brychtova, Y; Doubek, M; Mayer, J; Pospisilova, S; Mraz, M

HAEMATOLOGICA Open access

Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells

Boudny, M; Zemanova, J; Khirsariya, P; Borsky, M; Verner, J; Cerna, J; Oltova, A; Seda, V; Mraz, M; Jaros, J; Jaskova, Z; Spunarova, M; Brychtova, Y; Soucek, K; Drapela, S; Kasparkova, M; Mayer, J; Pa...

doi: 10.3324/haematol.2018.203430

2018

LEUKEMIA

Rituximab primarily targets an intra-clonal BCR signaling proficient CLL subpopulation characterized by high CD20 levels

Pavlasova, G; Borsky, M; Svobodova, V; Oppelt, J; Cerna, K; Novotna, J; Seda, V; Fojtova, M; Fajkus, J; Brychtova, Y; Doubek, M; Pospisilova, S; Mayer, J; Mraz, M

doi: 10.1038/s41375-018-0211-0

Blood

miR-150 downregulation contributes to the high-grade transformation of follicular lymphoma by upregulating FOXP1 levels

Musilova, K; Devan, J; Cerna, K; Seda, V; Pavlasova, G; Sharma, S; Oppelt, J; Pytlik, R; Prochazka, V; Prouzova, Z; Trbusek, M; Zlamalikova, L; Liskova, K; Kruzova, L; Jarosova, M; Mareckova, A; Korna...

2017

MOLECULAR CANCER THERAPEUTICS

The identification of combinatorial therapeutic approaches with BCR inhibitors in B cell malignancies

Pavlasova, G; Musilova, K; Seda, V; Cerna, K; Vojackova, E; Svobodova, V; Mraz, M

HAEMATOLOGICA

BCR SIGNALLING PROFICIENT CHRONIC LYMPHOCYTIC LEUKAEMIA B CELLS ARE PRONE TO RITUXIMAB MEDIATED ELIMINATION IN VIVO

Pavlasova, G; Borsky, M; Svobodova, V; Musilova, K; Cerna, K; Seda, V; Osickova, J; Brychtova, Y; Doubek, M; Pospisilova, S; Mayer, J; Mraz, M

LEUKEMIA & LYMPHOMA

MicroRNA induced by DNA damage response regulates the expression of FOXP1 and therapy response in CLL

Mraz, M; Cerna, K; Oppelt, J; Seda, V; Musilova, K; Pavlasova, G; Mayer, J; Pospisilova, S

2016

HAEMATOLOGICA

IBRUTINIB INHIBITS CD20 UP-REGULATION ON CLL B CELLS MEDIATED BY THE CXCR4/SDF-1 AXIS

Pavlasova, G; Borsky, M; Seda, V; Cerna, K; Osickova, J; Doubek, M; Mayer, J; Calogero, R; Pospisilova, S; Davids, M; Brown, J; Mraz, M

BLOOD

Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis

Pavlasova, G; Borsky, M; Seda, V; Cerna, K; Osickova, J; Doubek, M; Mayer, J; Calogero, R; Trbusek, M; Pospisilova, S; Davids, MS; Kipps, TJ; Brown, JR; Mraz, M

doi: 10.1182/blood-2016-04-709519

2015

EUROPEAN JOURNAL OF HAEMATOLOGY

B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells

Seda, V; Mraz, M

doi: 10.1111/ejh.12427

LEUKEMIA & LYMPHOMA

Microenvironmental interactions up-regulate CD20 expression in CLL B cells, but confer resistance to rituximab

Pavlasova, G; Borsky, M; Seda, V; Cerna, K; Osickova, J; Mayer, J; Pospisilova, S; Davids, M; Brown, J; Mraz, M

BLOOD

Microenvironmental Interactions up-Regulate CD20 Expression in CLL B Cells through the CXCR4/SDF-1 Axis: Implications for CD20-Targeting Antibodies and the Use of BCR-Inhibitors in Combination

Pavlasova, G; Seda, V; Borsky, M; Cerna, K; Osickova, J; Mayer, J; Pospisilova, S; Davids, MS; Brown, JR; Mraz, M

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