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The oro- and craniofacial complex originates from different embryonic lineages and is subject to continuous remodeling throughout life. Wnt signaling is a pivotal regulator of these processes, directing craniofacial development, tooth morphogenesis, and the long-term maintenance of skeletal and dental tissues. In the first part of the talk, Dr. Julian Petersen will present how Wnt1 differentially influences neural crest- and mesoderm-derived lineages, shaping bone and tooth development and contributing to postnatal tissue homeostasis.
In the second part, he will present an outlook on his group's recent work examining bone remodeling during orthodontic tooth movement. He will also share insights into the technical challenges of applying spatial transcriptomics to mineralized tooth and bone samples, and how overcoming these hurdles enables the generation of high-resolution molecular maps of early force responses in alveolar bone and periodontal tissues.
