Lenka Radová, Ph.D.

2018

• Sana, J; Busek, P; Fadrus, P; Besse, A; Radova, L; Vecera, M; Reguli, S; Stollinova Sromova, L; Hilser, M; Lipina, R; Lakomy, R; Kren, L; Smrcka, M; Sedo, A; Slaby, O., 2018: Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival. SCIENTIFIC REPORTS , doi: 10.1038/s41598-018-20929-6
• Plesingerova, H; Janovska, P; Mishra, A; Smyckova, L; Poppova, L; Libra, A; Plevova, K; Ovesna, P; Radova, L; Doubek, M; Pavlova, S; Pospisilova, S; Bryja, V, 2018: Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia. HAEMATOLOGICA 103(2), p. 313 - 324, doi: 10.3324/haematol.2017.178699
• Kubesova, B; Pavlova, S; Malcikova, J; Kabathova, J; Radova, L; Tom, N; Tichy, B; Plevova, K; Kantorova, B; Fiedorova, K; Slavikova, M; Bystry, V; Kissova, J; Gisslinger, B; Gisslinger, H; Penka, M; Mayer, J; Kralovics, R; Pospisilova, S; Doubek, M, 2018: Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status. LEUKEMIA 32(2), p. 450 - 461, doi: 10.1038/leu.2017.230
• Zaprazna, K; Basu, A; Tom, N; Jha, V; Hodawadekar, S; Radova, L; Malcikova, J; Tichy, B; Pospisilova, S; Atchison, ML, 2018: Transcription factor YY1 can control AID-mediated mutagenesis in mice. EUROPEAN JOURNAL OF IMMUNOLOGY 48(2), p. 273 - 282, doi: 10.1002/eji.201747065

2017

• Valianatos, G; Valcikova, B; Growkova, K; Verlande, A; Mlcochova, J; Radova, L; Stetkova, M; Vyhnakova, M; Slaby, O; Uldrijan, S, 2017: A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein. PLOS ONE 12(10), doi: 10.1371/journal.pone.0185801
• de Montaigu, A; Oeljeklaus, J; Krahn, JH; Suliman, MNS; Halder, V; de Ansorena, E; Nickel, S; Schlicht, M; Plihal, O; Kubiasova, K; Radova, L; Kracher, B; Toth, R; Kaschani, F; Coupland, G; Kombrink, E; Kaiser, M, 2017: The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock. ACS CHEMICAL BIOLOGY 12(6), p. 1466 - 1471, doi: 10.1021/acschembio.6b00978
• Horak, S; Sovova, E; Pastucha, D; Konecny, P; Radova, L; Calabova, N; Janoutova, J; Janout, V, 2017: COMPREHENSIVE GROUP THERAPY OF OBESITY AND ITS IMPACT ON SELECTED ANTHROPOMETRIC AND POSTURAL PARAMETERS. CENTRAL EUROPEAN JOURNAL OF PUBLIC HEALTH 25(4), p. 326 - 331, doi: 10.21101/cejph.a4780
• Vychytilova-Faltejskova, P; Merhautova, J; Machackova, T; Gutierrez-Garcia, I; Garcia-Solano, J; Radova, L; Brchnelova, D; Slaba, K; Svoboda, M; Halamkova, J; Demlova, R; Kiss, I; Vyzula, R; Conesa-Zamora, P; Slaby, O, 2017: MiR-215-5p is a tumor suppressor in colorectal cancer targeting EGFR ligand epiregulin and its transcriptional inducer HOXB9. ONCOGENESIS 6, doi: 10.1038/s41389-017-0006-6
• Sedlarikova, L; Gromesova, B; Kubaczkova, V; Radova, L; Filipova, J; Jarkovsky, J; Brozova, L; Velichova, R; Almasi, M; Penka, M; Bezdekova, R; Stork, M; Adam, Z; Pour, L; Krejci, M; Kuglik, P; Hajek, R; Sevcikova, S, 2017: Deregulated expression of long non-coding RNA UCA1 in multiple myeloma. EUROPEAN JOURNAL OF HAEMATOLOGY 99(3), p. 223 - 233, doi: 10.1111/ejh.12908
• Ruzicka, M; Kulhanek, P; Radova, L; Cechova, A; Spackova, N; Fajkusova, L; Reblova, K, 2017: DNA mutation motifs in the genes associated with inherited diseases. PLOS ONE 12(8), doi: 10.1371/journal.pone.0182377
• Bencurova, P; Baloun, J; Musilova, K; Radova, L; Tichy, B; Pail, M; Zeman, M; Brichtova, E; Hermanova, M; Pospisilova, S; Mraz, M; Brazdil, M, 2017: MicroRNA and mesial temporal lobe epilepsy with hippocampal sclerosis: Whole miRNome profiling of human hippocampus. EPILEPSIA 58(10), p. 1782 - 1793, doi: 10.1111/epi.13870
• Kantorova, B; Malcikova, J; Brazdilova, K; Borsky, M; Plevova, K; Smardova, J; Radova, L; Tom, N; Trbusek, M; Diviskova, E; Francova, HS; Navrkalova, V; Doubek, M; Brychtova, Y; Mayer, J; Pospisilova, S, 2017: Single cell analysis revealed a coexistence of NOTCH1 and TP53 mutations within the same cancer cells in chronic lymphocytic leukaemia patients. BRITISH JOURNAL OF HAEMATOLOGY 178(6), p. 979 - 982, doi: 10.1111/bjh.14176
• Ondracek, J; Fadrus, P; Sana, J; Besse, A; Loja, T; Vecera, M; Radova, L; Smrcka, M; Slampa, P; Slaby, O, 2017: Global MicroRNA Expression Profiling Identifies Unique MicroRNA Pattern of Radioresistant Glioblastoma Cells. ANTICANCER RESEARCH 37(3), p. 1099 - 1104, doi: 10.21873/anticanres.11422

2016

• Poppova, L; Janovska, P; Plevova, K; Radova, L; Plesingerova, H; Borsky, M; Kotaskova, J; Kantorova, B; Hlozkova, M; Figulova, J; Brychtova, Y; Machalova, M; Urik, M; Doubek, M; Kozubik, A; Pospisilova, S; Pavlova, S; Bryja, V, 2016: Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV. BRITISH JOURNAL OF HAEMATOLOGY 175(5), p. 851 - 859, doi: 10.1111/bjh.14312
• Hernandez-Sanchez, M; Radova, L; Kotaskova, J; Tamborero, D; Rodriguez, AE; Plevova, K; Abaigar, M; Bikos, V; Benito, R; Takacova, S; Quijada, M; Martin, AA; Alcoceba, M; de Coca, AG; Doubek, M; Gonzalez, M; Lopez-Bigas, N; Pospisilova, S; Hernandez-Rivas, JM, 2016: Analysis of Clonal Evolution in Chronic Lymphocytic Leukemia from Inactive to Symptomatic Disease Prior Treatment Using Whole-Exome Sequencing. BLOOD 128(22)
• Navrkalova, V; Young, E; Baliakas, P; Radova, L; Sutton, LA; Plevova, K; Mansouri, L; Ljungstrom, V; Ntoufa, S; Davis, Z; Juliusson, G; Smedby, KE; Belessi, C; Panagiotidis, P; Touloumenidou, T; Davi, F; Langerak, AW; Ghia, P; Strefford, JC; Oscier, D; Mayer, J; Stamatopoulos, K; Pospisilova, S; Rosenquist, R; Trbusek, M, 2016: ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres. HAEMATOLOGICA 101(9), doi: 10.3324/haematol.2016.142968
• Kubesova, B; Pavlova, S; Malcikova, J; Kabathova, J; Radova, L; Tom, N; Tichy, B; Plevova, K; Kantorova, B; Fiedorova, K; Kissova, J; Gisslinger, B; Gisslinger, H; Mayer, J; Kralovics, R; Pospisilova, S; Doubek, M, 2016: Low-Burden TP53 Mutations Occur in Chronic Phase of Myeloproliferative Neoplasms Regardless of Hydroxyurea Administration, Disease Type, and JAK2 Status. BLOOD 128(22)
• Melazzini, F; Palombo, F; Balduini, A; De Rocco, D; Marconi, C; Noris, P; Gnan, C; Pippucci, T; Bozzi, V; Faleschini, M; Barozzi, S; Doubek, M; Di Buduo, CA; Kozubik, KS; Radova, L; Loffredo, G; Pospisilova, S; Alfano, C; Seri, M; Balduini, CL; Pecci, A; Savoia, A, 2016: Clinical and pathogenic features of ETV6-related thrombocytopenia with predisposition to acute lymphoblastic leukemia. HAEMATOLOGICA 101(11), p. 1333 - 1342, doi: 10.3324/haematol.2016.147496
• Zaprazna, K; Malcikova, J; Tom, N; Radova, L; Trbusek, M; Atchison, M; Pospisilova, S, 2016: ACTIVATION INDUCED DEAMINASE SPLICE VARIANTS EXPRESSED IN B CELL LEUKEMIA AND LYMPHOMA DO NOT RETAIN THEIR CATALYTIC ACTIVITY. HAEMATOLOGICA 101, p. 429 - 430
• Kryukov, F; Nemec, P; Radova, L; Kryukova, E; Okubote, S; Minarik, J; Stefanikova, Z; Pour, L; Hajek, R, 2016: Centrosome associated genes pattern for risk sub-stratification in multiple myeloma. JOURNAL OF TRANSLATIONAL MEDICINE 14, doi: 10.1186/s12967-016-0906-9
• Poppova, L; Janovska, P; Plevova, K; Radova, L; Plesingerova, H; Borsky, M; Kotaskova, J; Kantorova, B; Hlozkova, M; Figulova, J; Brychtova, Y; Doubek, M; Kozubik, A; Pospisilova, S; Pavlova, S; Bryja, V, 2016: DECREASED EXPRESSION OF WNT3, A CANONICAL WNT PATHWAY LIGAND, IS FREQUENT IN CHRONIC LYMPHOCYTIC LEUKEMIA PROGRESSION AND IDENTIFIES PATIENTS WITH SHORT TREATMENT-FREE SURVIVAL IN MUTATED IGHV SUBSET. HAEMATOLOGICA 101, p. 423 - 424
• Mlcochova, H; Machackova, T; Rabien, A; Radova, L; Fabian, P; Iliev, R; Slaba, K; Poprach, A; Kilic, E; Stanik, M; Redova-Lojova, M; Svoboda, M; Dolezel, J; Vyzula, R; Jung, K; Slaby, O, 2016: Epithelial-mesenchymal transition-associated microRNA/mRNA signature is linked to metastasis and prognosis in clear-cell renal cell carcinoma. SCIENTIFIC REPORTS 6, doi: 10.1038/srep31852
• Sedlarikova, L; Gromesova, B; Kubaczkova, V; Radova, L; Almasi, M; Penka, M; Adam, Z; Pour, L; Krejci, M; Sevcikova, S; Hajek, R, 2016: LONG NON-CODING RNAS IN MULTIPLE MYELOMA. HAEMATOLOGICA 101, p. 518 - 518
• Vychytilova-Faltejskova, P; Radova, L; Sachlova, M; Kosarova, Z; Slaba, K; Fabian, P; Grolich, T; Prochazka, V; Kala, Z; Svoboda, M; Kiss, I; Vyzula, R; Slaby, O, 2016: Serum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer. CARCINOGENESIS 37(10), p. 941 - 950, doi: 10.1093/carcin/bgw078
• Vychytilova-Faltejskova, P; Pesta, M; Radova, L; Liska, V; Daum, O; Kala, Z; Svoboda, M; Kiss, I; Slaby, O, 2016: Genome-wide microRNA Expression Profiling in Primary Tumors and Matched Liver Metastasis of Patients with Colorectal Cancer. CANCER GENOMICS & PROTEOMICS 13(4), p. 311 - 316
• Nemecek, R; Berkovcova, J; Radova, L; Kazda, T; Mlcochova, J; Vychytilova-Faltejskova, P; Slaby, O; Svoboda, M, 2016: Mutational analysis of primary and metastatic colorectal cancer samples underlying the resistance to cetuximab-based therapy. ONCOTARGETS AND THERAPY 9, p. 4695 - 4703, doi: 10.2147/OTT.S102891
• Janikova, M; Zizkova, V; Skarda, J; Kharaishvili, G; Radova, L; Kolar, Z, 2016: Prognostic significance of miR-23b in combination with P-gp, MRP and LRP/MVP expression in non-small cell lung cancer. NEOPLASMA 63(4), p. 576 - 587, doi: 10.4149/neo_2016_411

2015

• Slaby, O; Srovnal, J; Radova, L; Gregar, J; Juracek, J; Luzna, P; Svoboda, M; Hajduch, M; Ehrmann, J, 2015: Dynamic changes in microRNA expression profiles reflect progression of Barrett´s esophagus to esophageal adenocarcinoma. CARCINOGENESIS 36(5), p. 521 - 527, doi: 10.1093/carcin/bgv023
• Malcikova, J; Stano-Kozubik, K; Tichy, B; Kantorova, B; Pavlova, S; Tom, N; Radova, L; Smardova, J; Pardy, F; Doubek, M; Brychtova, Y; Mraz, M; Plevova, K; Diviskova, E; Oltova, A; Mayer, J; Pospisilova, S; Trbusek, M, 2015: Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia. LEUKEMIA 29(4), p. 877 - 885, doi: 10.1038/leu.2014.297
• Mlcochova, J; Faltejskova-Vychytilova, P; Ferracin, M; Zagatti, B; Radova, L; Svoboda, M; Nemecek, R; John, S; Kiss, I; Vyzula, R; Negrini, M; Slaby, O, 2015: MicroRNA expression profiling identifies miR-31-5p/3p as associated with time to progression in wild-type RAS metastatic colorectal cancer treated with cetuximab. ONCOTARGET 6(36), p. 38695 - 38704
• Besse, L; Sedlarikova, L; Kryukov, F; Nekvindova, J; Radova, L; Slaby, O; Kuglik, P; Almasi, M; Penka, M; Krejci, M; Adam, Z; Pour, L; Sevcikova, S; Hajek, R, 2015: Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma. PLOS ONE 10(9), doi: 10.1371/journal.pone.0137294
• Navrkalova, V; Young, E; Baliakas, P; Radova, L; Plevova, K; Sutton, LA; Mansouri, L; Ljungstrom, V; Ntoufa, S; Davis, Z; Juliusson, G; Smedby, KE; Belessi, C; Panagiotidis, P; Davi, F; Langerak, AW; Ghia, P; Strefford, JC; Oscier, DG; Stamatopoulos, K; Pospisilova, S; Rosenquist, R; Trbusek, M, 2015: ATM Mutations in Major Stereotyped CLL Subsets: Enrichment in Subset #2 is Associated with Unfavourable Outcome. BLOOD 126(23)
• Tom, N; Malcikova, J; Radova, L; Kantorova, B; Pardy, F; Pavlova, S; Pal, K; Mraz, M; Tichy, B; Doubek, M; Brychtova, Y; Plevova, K; Mayer, J; Trbusek, M; Pospisilova, S, 2015: MUTATIONS IN THE TP53 GENE SHOW FEATURES OF SOMATIC HYPERMUTATION PROCESS WITH PROMINENT DIFFERENCE BETWEEN IGHV MUTATED AND UNMUTATED CHRONIC LYMPHOCYTIC LEUKEMIA. HAEMATOLOGICA 100, p. 224 - 225
• Kryukov, F; Nemec, P; Radova, L; Kryukova, E; Kufova, Z; Sedlarikova, L; Sevcikova, S; Hajek, R, 2015: CENTROSOME ASSOCIATED GENES PATTERN FOR RISK SUBSTRATIFICATION IN MULTIPLE MYELOMA. HAEMATOLOGICA 100, p. 247 - 247
• Besse, LK; Sedlarikova, L; Kryukov, F; Nekvindova, J; Radova, L; Almasi, M; Pelcova, J; Minarik, J; Pika, T; Pikalova, Z; Scudla, V; Krejci, M; Adam, Z; Pour, L; Hajek, R; Sevcikova, S, 2015: Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenstrom macroglobulinemia. AMERICAN JOURNAL OF HEMATOLOGY 90(3), p. E51 - E52, doi: 10.1002/ajh.23910
• Merhautova, J; Hezova, R; Poprach, A; Kovarikova, A; Radova, L; Svoboda, M; Vyzula, R; Demlova, R; Slaby, O, 2015: miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib. BIOMED RESEARCH INTERNATIONAL , doi: 10.1155/2015/941980

2014

• Kubiczkova, L; Sedlarikova, L; Kryukov, F; Nekvindova, J; Radova, L; Vrabel, D; Adam, Z; Pour, L; Sevcikova, S; Hajek, R, 2014: CIRCULATING MIR-34A AND MIR-130A AS BIOMARKERS OF EXTRAMEDULLARY DISEASE. HAEMATOLOGICA 99, p. 97 - 97
• Pospisilova, D; Holub, D; Zidova, Z; Sulovska, L; Houda, J; Mihal, V; Hadacova, I; Radova, L; Dzubak, P; Hajduch, M; Divoky, V; Horvathova, M, 2014: Hepcidin levels in Diamond-Blackfan anemia reflect erythropoietic activity and transfusion dependency. HAEMATOLOGICA 99(7), doi: 10.3324/haematol.2014.104034

• Analysis of changes in genome and its expression in chronic lymphocytic leukemia patients during the disease development (NS10439), Ministry of Health - Departmental Programme of Research and Development (2008-2011), 2009 - 2011
• Studium mikroRNA a genů asociovaných s procesem epiteliálně-mezenchymální tranzice jako potenciálních markerů pro predikci rizika a časný záchyt metastazování u pacientů s renálním karcinomem (NT13547-4/2012), Ministry of Health of the CR, 2012 - 2015
• Identification and functional characterization of microRNAs with predictive significance in patients with glioblastoma (NT/11214), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2010 - 2013
• Development of microRNA diagnostic panel for identification Barret esophagus patients at high-risk of progression to adenocarcinoma (NT13585), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2014
• Complex characterization of molecular genetic changes in glioblastoma multiforme and its relapses, and evaluation of their possible significance in oncologic therapy and therapy effect (NT/13581), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2015
• MicroRNA analysis in glioblastoma stem cells: prediction of therapy response and identification of new therapeutic targets in glioblastoma patients (NT/13514), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2015
• Analysis of EGFR signalling and microRNA expression profiles in prediction of response to anti-EGFR (NT/13860), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2015
• Real-time PCR soupravy pro diagnostiku v onkologii (FR-TI2/254), Ministerstvo průmyslu a obchodu ČR, 2010 - 2013
• SuPReMMe - Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny (CZ.1.07/2.3.00/20.0045), Ministerstvo školství, mládeže a tělovýchovy ČR, 2011 - 2014
• NGS-PTL - Next Generation Sequencing platform for targeted Personalized Therapy of Leukemia (306242), Evropská unie, 2012 - 2015
• Involvement of nuclear HMGB proteins in sensitizing of human cells to anticancer drugs inhibiting DNA topoizomerases (GAP301/10/0590), Czech Science Foundation - Standard Grants, 2010 - 2012
• Functional and structural changes of microRNAs in lymphoproliferative malignancies and their impact on prognosis and prediction of therapy response (NT11218), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2010 - 2015
• Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies (MSM0021622430), Ministerstvo školství, mládeže a tělovýchovy ČR, 2007 - 2013
• Expression and function of activation-induced cytidine deaminase splice variants in normal B cell physiology and chronic lymphocytic leukemia (3SGA5792), Jihomoravský kraj, 2013 - 2016
• Development of diagnostic panel of circulating microRNAs for non-invasive early diagnostics and follow-up of colorectal cancer patients (NT/13549), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2015