Lecture Seminar Series

PI Seminar: ADARs, the RNA Editing Enzymes That Are Key to Combating Disease

About event

This is part of the Principal Investigator Seminar Series.

 


ABSTRACT:

ADAR RNA editing enzymes deaminate adenosine bases to inosines in double-stranded (ds)RNA. During translation, inosine is read as guanosine and this editing diversifies the proteins present in the organism. In vertebrates, the editing by ADAR1 protein helps to distinguish between self and non-self dsRNA and is essential for the innate immune response. A mutation in human ADAR1 causes Aicardi-Goutières Syndrome in which children with a defective ADAR1 aberrantly express antiviral interferon and die with encephalitis. Investigation of the Fulani ethnic group that are resistant to malaria show a marked decease in RNA editing and we also observe a decrease in parasitaemia in our Adar1 mouse model when challenged with P. yoelii.

The vertebrate ADAR2 protein is involved primarily in editing transcripts encoding ion channels subunits and other proteins, particularly in the CNS. We have found that mutations in human ADAR2 cause Epilepsy of Infancy with Migrating Focal Seizures (EIMFS). Drosophila has a single Adar gene encoding an ADAR2 ortholog. Adar null mutant larval motorneurons have aberrantly increased excitability and elevated levels of synaptic vesicles and associated proteins. Adar mutants show reduced viability and severe locomotion defects and go on to develop age-dependent neurodegeneration with enlarged vacuoles in retina and brain

Date

4. 3. 2022, 13:00
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Speaker

Mary O' Connell, Era Chair – RNA and Immunity, CEITEC MU
Mary O' Connell, Era Chair – RNA and Immunity, CEITEC MU

Venue

University Campus Bohunice, Building B11, Room 205