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Our laboratory investigates the earliest stages of mammalian development, with a primary focus on human oocyte maturation, fertilization, and preimplantation embryo development. Using advanced imaging approaches, including live-cell microscopy and electron microscopy, we study how eggs acquire competence for fertilization and embryogenesis. We also explore factors that define embryo quality and influence early cell fate decisions, with the aim of improving outcomes of assisted reproduction. Complementary work in mammalian model systems, including mouse and bovine, allows us to dissect conserved and species-specific mechanisms that cannot be fully resolved in humans alone. This talk will highlight how basic cell biology of the egg and embryo shapes reproductive success and informs assisted reproduction.
