About event
Cancer is canonically understood as a genetically driven process, however, in the case of neoplastic B lymphocytes, this is very importantly modified by their ability to physiologically clonally proliferate upon stimulation by antigen and interaction with T lymphocytes. The talk will focus on understanding how leukemic B cells migrate to immune niches to achieve interactions with non-malignant cells, and how this can be used therapeutically.
Dr. Marek Mraz is interested in the regulation of microenvironmental interactions in CLL and other B cell malignancies, especially B-T cell interactions and B-cell receptor (BCR) signaling. He conducted post-doctoral work with Prof. Thomas Kipps (Univ. California-San Diego), and since 2016 is a group leader at the CEITEC Masaryk University and at University Hospital Brno (Czech Republic; ceitec.cz/mrazlab). He is best known for his work describing the role of non-coding RNAs (microRNAs) in BCR pathway, p53 pathway, and B-T cell interactions. In 2018 he was awarded the prestigious ERC grant.
This is part of the Principal Investigator Seminar Series.
