Prof. Jiří Fajkus

2019

• Schorova, S; Fajkus, J; Zaveska Drabkova, L; Honys, D; Schrumpfova, PP, 2019: The plant Pontin and Reptin homologues, RuvBL1 and RuvBL2a, colocalize with TERT and TRB proteins in vivo, and participate in telomerase biogenesis. PLANT JOURNAL 98(2), p. 195 - 212, doi: 10.1111/tpj.14306
• Goffova, I; Vagnerova, R; Peska, V; Franek, M; Havlova, K; Hola, M; Zachova, D; Fojtova, M; Cuming, A; Kamisugi, Y; Angelis, KJ; Fajkus, J, 2019: Roles of RAD51 and RTEL1 in telomere and rDNA stability in Physcomitrella patens. PLANT JOURNAL 98(6), p. 1090 - 1105, doi: 10.1111/tpj.14304
• Peska, V; Mandakova, T; Ihradska, V; Fajkus, J, 2019: Comparative Dissection of Three Giant Genomes: Allium cepa, Allium sativum, and Allium ursinum. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20(3), doi: 10.3390/ijms20030733
• Fajkus, P; Peška, V; Závodník, M; Fojtová, M; Fulnečková, J; Dobias, Š; Kilar, A; Dvořáčková, M; Zachová, D; Nečasová, I; Sims, J; Sýkorová, E; Fajkus, J, 2019: Telomerase RNAs in land plants. NUCLEIC ACIDS RESEARCH , doi: 10.1093/nar/gkz695

2018

• Sovakova, PP; Magdolenova, A; Konecna, K; Rajecka, V; Fajkus, J; Fojtova, M, 2018: Telomere elongation upon transfer to callus culture reflects the reprogramming of telomere stability control in Arabidopsis. PLANT MOLECULAR BIOLOGY 98(2018-02-01T00:00:00.000), p. 81 - 99, doi: 10.1007/s11103-018-0765-2
• Pavlasova, G; Borsky, M; Svobodova, V; Oppelt, J; Cerna, K; Novotna, J; Seda, V; Fojtova, M; Fajkus, J; Brychtova, Y; Doubek, M; Pospisilova, S; Mayer, J; Mraz, M, 2018: Rituximab primarily targets an intra-clonal BCR signaling proficient CLL subpopulation characterized by high CD20 levels. LEUKEMIA 32(9), p. 2028 - 2031, doi: 10.1038/s41375-018-0211-0
• Dvorackova, M; Raposo, B; Matula, P; Fuchs, J; Schubert, V; Peska, V; Desvoyes, B; Gutierrez, C; Fajkus, J, 2018: Replication of ribosomal DNA in Arabidopsis occurs both inside and outside the nucleolus during S phase progression. JOURNAL OF CELL SCIENCE 131(2), doi: 10.1242/jcs.202416
• Dvorackova, M; Fajkus, J, 2018: Visualization of the Nucleolus Using Ethynyl Uridine. FRONTIERS IN PLANT SCIENCE 9, doi: 10.3389/fpls.2018.00177

2017

• Jureckova, JF; Sykorova, E; Hafidh, S; Honys, D; Fajkus, J; Fojtova, M, 2017: Tissue-specific expression of telomerase reverse transcriptase gene variants in Nicotiana tabacum. PLANTA 245(3), p. 549 - 561, doi: 10.1007/s00425-016-2624-1
• Peska, V; Sitova, Z; Fajkus, P; Fajkus, J, 2017: BAL31-NGS approach for identification of telomeres de novo in large genomes. METHODS 114, p. 16 - 27, doi: 10.1016/j.ymeth.2016.08.017
• Vagnerova, R; Lukesova, A; Lukes, M; Roznovska, P; Hola, M; Fulneckova, J; Fajkus, J; Angelis, KJ, 2017: Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress. GENES 8(11), doi: 10.3390/genes8110331
• Brabencova, S; Ihnatova, I; Potesil, D; Fojtova, M; Fajkus, J; Zdrahal, Z; Lochmanova, G, 2017: Variations of Histone Modification Patterns: Contributions of Inter-plant Variability and Technical Factors. FRONTIERS IN PLANT SCIENCE 8, doi: 10.3389/fpls.2017.02084

2016

• Marecek, R; Lamos, M; Mikl, M; Barton, M; Fajkus, J; Rektor, I; Brazdil, M, 2016: What can be found in scalp EEG spectrum beyond common frequency bands. EEG-fMRI study. JOURNAL OF NEURAL ENGINEERING 13(4), doi: 10.1088/1741-2560/13/4/046026
• Schrumpfova, PP; Schorova, S; Fajkus, J, 2016: Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell. FRONTIERS IN PLANT SCIENCE 7, doi: 10.3389/fpls.2016.00851
• Pontvianne, F; Carpentier, MC; Durut, N; Pavlistova, V; Jaske, K; Schorova, S; Parrinello, H; Rohmer, M; Pikaard, CS; Fojtova, M; Fajkus, J; Saez-Vasquez, J, 2016: Identification of Nucleolus-Associated Chromatin Domains Reveals a Role for the Nucleolus in 3D Organization of the A. thaliana Genome. CELL REPORTS 16(6), p. 1574 - 1587, doi: 10.1016/j.celrep.2016.07.016

2015

• Muchova, V; Amiard, S; Mozgova, I; Dvorackova, M; Gallego, ME; White, C; Fajkus, J, 2015: Homology-dependent repair is involved in 45S rDNA loss in plant CAF-1 mutants. PLANT JOURNAL 81(2), p. 198 - 209, doi: 10.1111/tpj.12718
• Peska, V; Fajkus, P; Fojtova, M; Dvorackova, M; Hapala, J; Dvoracek, V; Polanska, P; Leitch, AR; Sykorova, E; Fajkus, J, 2015: Characterisation of an unusual telomere motif (TTTTTTAGGG)(n) in the plant Cestrum elegans (Solanaceae), a species with a large genome. PLANT JOURNAL 82(4), p. 644 - 654, doi: 10.1111/tpj.12839

2014

• Fojtova, M; Fajkus, J, 2014: Epigenetic Regulation of Telomere Maintenance. CYTOGENETIC AND GENOME RESEARCH 143(42064), p. 125 - 135, doi: 10.1159/000360775
• Schrumpfova, PP; Vychodilova, I; Dvorackova, M; Majerska, J; Dokladal, L; Schorova, S; Fajkus, J, 2014: Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase. PLANT JOURNAL 77(5), p. 770 - 781, doi: 10.1111/tpj.12428
• Ogrocka, A; Polanska, P; Majerova, E; Janeba, Z; Fajkus, J; Fojtova, M, 2014: Compromised telomere maintenance in hypomethylated Arabidopsis thaliana plants. NUCLEIC ACIDS RESEARCH 42(5), p. 2919 - 2931, doi: 10.1093/nar/gkt1285
• Majerova, E; Mandakova, T; Vu, GTH; Fajkus, J; Lysak, MA; Fojtova, M, 2014: Chromatin features of plant telomeric sequences at terminal vs. internal positions. FRONTIERS IN PLANT SCIENCE 5, p. 593 - , doi: 10.3389/fpls.2014.00593

2013

• Kruta, M; Balek, L; Hejnova, R; Dobsakova, Z; Eiselleova, L; Matulka, K; Barta, T; Fojtik, P; Fajkus, J; Hampl, A; Dvorak, P; Rotrekl, V, 2013: Decrease in Abundance of Apurinic/Apyrimidinic Endonuclease Causes Failure of Base Excision Repair in Culture-Adapted Human Embryonic Stem Cells. STEM CELLS 31(4), p. 693 - 702, doi: 10.1002/stem.1312
• Fulneckova, J; Sevcikova, T; Fajkus, J; Lukesova, A; Lukes, M; Vlcek, C; Lang, BF; Kim, E; Elias, M; Sykorova, E, 2013: A Broad Phylogenetic Survey Unveils the Diversity and Evolution of Telomeres in Eukaryotes. GENOME BIOLOGY AND EVOLUTION 5(3), p. 468 - 483, doi: 10.1093/gbe/evt019
• Cincarova, L; Zdrahal, Z; Fajkus, J, 2013: New perspectives of valproic acid in clinical practice. EXPERT OPINION ON INVESTIGATIONAL DRUGS 22(12), p. 1535 - 1547, doi: 10.1517/13543784.2013.853037
• Pontvianne, F; Blevins, T; Chandrasekhara, C; Mozgova, I; Hassel, C; Pontes, OMF; Tucker, S; Mokros, P; Muchova, V; Fajkus, J; Pikaard, CS, 2013: Subnuclear partitioning of rRNA genes between the nucleolus and nucleoplasm reflects alternative epiallelic states. GENES & DEVELOPMENT 27(14), p. 1545 - 1550, doi: 10.1101/gad.221648.113

2012

• Fulneckova, J; Hasikova, T; Fajkus, J; Lukesova, A; Elias, M; Sykorova, E, 2012: Dynamic Evolution of Telomeric Sequences in the Green Algal Order Chlamydomonadales. GENOME BIOLOGY AND EVOLUTION 4(3), p. 248 - 264, doi: 10.1093/gbe/evs007
• Sykorova, E; Fulneckova, J; Mokros, P; Fajkus, J; Fojtova, M; Peska, V, 2012: Three TERT genes in Nicotiana tabacum. CHROMOSOME RESEARCH 20(4), p. 381 - 394, doi: 10.1007/s10577-012-9282-3
• Polanska, E; Dobsakova, Z; Dvorackova, M; Fajkus, J; Stros, M, 2012: HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction. CHROMOSOMA 121(4), p. 419 - 431, doi: 10.1007/s00412-012-0373-x
• Ogrocka, A; Sykorova, E; Fajkus, J; Fojtova, M, 2012: Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment. JOURNAL OF EXPERIMENTAL BOTANY 63(11), p. 4233 - 4241, doi: 10.1093/jxb/ers107
• Cincarova, L; Lochmanova, G; Novakova, K; Sultesova, P; Konecna, H; Fajkusova, L; Fajkus, J; Zdrahal, Z, 2012: A combined approach for the study of histone deacetylase inhibitors. MOLECULAR BIOSYSTEMS 8(11), p. 2937 - 2945, doi: 10.1039/c2mb25136a

2011

• Majerska, J; Sykorova, E; Fajkus, J, 2011: Non-telomeric activities of telomerase. MOLECULAR BIOSYSTEMS 7(4), p. 1013 - 1023, doi: 10.1039/c0mb00268b
• Majerova, E; Fojtova, M; Mandakova, T; Fajkus, J, 2011: Methylation of plant telomeric DNA: what do the results say?. PLANT MOLECULAR BIOLOGY 77(6), p. 533 - 536, doi: 10.1007/s11103-011-9834-5
• Schrumpfova, PP; Fojtova, M; Mokros, P; Grasser, KD; Fajkus, J, 2011: Role of HMGB Proteins in Chromatin Dynamics and Telomere Maintenance in Arabidopsis thaliana. CURRENT PROTEIN & PEPTIDE SCIENCE 12(2), p. 105 - 111
• Peska, V; Schrumpfova, PP; Fajkus, J, 2011: Using the Telobox to Search for Plant Telomere Binding Proteins. CURRENT PROTEIN & PEPTIDE SCIENCE 12(2), p. 75 - 83
• Fajkus, J, 2011: Proteins in Signalling Pathways and Chromosome Stability in Plants. CURRENT PROTEIN & PEPTIDE SCIENCE 12(2), p. 74 - 74
• Fojtova, M; Peska, V; Dobsakova, Z; Mozgova, I; Fajkus, J; Sykorova, E, 2011: Molecular analysis of T-DNA insertion mutants identified putative regulatory elements in the AtTERT gene. JOURNAL OF EXPERIMENTAL BOTANY 62(15), p. 5531 - 5545, doi: 10.1093/jxb/err235
• Majerova, E; Fojtova, M; Mozgova, I; Bittova, M; Fajkus, J, 2011: Hypomethylating drugs efficiently decrease cytosine methylation in telomeric DNA and activate telomerase without affecting telomere lengths in tobacco cells. PLANT MOLECULAR BIOLOGY 77(42128), p. 371 - 380, doi: 10.1007/s11103-011-9816-7

2010

• Dvorackova, M; Rossignol, P; Shaw, PJ; Koroleva, OA; Doonan, JH; Fajkus, J, 2010: AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin. PLANT JOURNAL 61(4), p. 637 - 649, doi: 10.1111/j.1365-313X.2009.04094.x
• Fojtova, M; Wong, JTY; Dvorackova, M; Yan, KTH; Sykorova, E; Fajkus, J, 2010: Telomere maintenance in liquid crystalline chromosomes of dinoflagellates. CHROMOSOMA 119(4 I), p. 485 - 493, doi: 10.1007/s00412-010-0272-y
• Mozgova, I; Mokros, P; Fajkus, J, 2010: Dysfunction of Chromatin Assembly Factor 1 Induces Shortening of Telomeres and Loss of 45S rDNA in Arabidopsis thaliana. PLANT CELL 22(8), p. 2768 - 2780, doi: 10.1105/tpc.110.076182
• Chester, M; Sykorova, E; Fajkus, J; Leitch, AR, 2010: Single Integration and Spread of a Copia-Like Sequence Nested in rDNA Intergenic Spacers of Allium cernuum (Alliaceae). CYTOGENETIC AND GENOME RESEARCH 129(1 III), p. 35 - 46, doi: 10.1159/000312959
• Jerabkova, B; Marek, J; Buckova, H; Kopeckova, L; Vesely, K; Valickova, J; Fajkus, J; Fajkusova, L, 2010: Keratin mutations in patients with epidermolysis bullosa simplex: correlations between phenotype severity and disturbance of intermediate filament molecular structure. BRITISH JOURNAL OF DERMATOLOGY 162(5), p. 1004 - 1013, doi: 10.1111/j.1365-2133.2009.09626.x
• Goldmann, R; Tichy, L; Freiberger, T; Zapletalova, P; Letocha, O; Soska, V; Fajkus, J; Fajkusova, L, 2010: Genomic characterization of large rearrangements of the LDLR gene in Czech patients with familial hypercholesterolemia. BMC MEDICAL GENETICS 11, doi: 10.1186/1471-2350-11-115

2009

• Hofr, C., Sultesova, P., Zimmermann, M., Mozgova, I., Schrumpfova, P. P., Wimmerova, M., Fajkus, J.,, 2009: Single-Myb-histone proteins from Arabidopsis thaliana: a quantitative study of telomere-binding specificity and kinetics. BIOCHEMICAL JOURNAL 419, p. 221 - 228

• Molekulární podstata evolučních přeměn telomer u rostlin řádu Asparagales (GA17-09644S), Grantová agentura ČR, 2017 - 2019
• Genomické a proteomické přístupy k objasnění biologických procesů (MUNI/A/0829/2017) (MUNI/A/0829/2017), Grant Agency of Masaryk University, 2018 - 2018
• Centre of plant synthetic biology for bio-engineering and sustainable agriculture (763672), Evropská unie, 2017 - 2018
• Struktura a dynamika 45S rDNA lokusů v Arabidopsis thaliana (LH15189), Ministerstvo školství, mládeže a tělovýchovy ČR, 2015 - 2017
• Funkční a fyzická spojení oblastí organizátorů jadérka a telomer (7AMB16FR014), Ministerstvo školství, mládeže a tělovýchovy ČR, 2016 - 2017
• Strukturní a funkční komponenty rostlinných telomer (GA13-06943S), Grantová agentura ČR, 2013 - 2017
• Úloha proteinu Nse, podjednotek komplexu SMC5/6, v procesech stabilizujících pozastavené replikacní vidlice (GA13-00774S), Grantová agentura ČR, 2013 - 2016
• Studium dynamiky telomerových proteinových komplexů zajišťujících stabilitu genomu (LH13054), Ministerstvo školství, mládeže a tělovýchovy ČR, 2013 - 2015
• CEITEC - Central European Institute of Technology (CZ.1.05/1.1.00/02.0068), Ministerstvo školství, mládeže a tělovýchovy ČR, 2011 - 2015
• Telomery a stabilita genomu u nižších rostlin (GA13-06595S), Grantová agentura ČR, 2013 - 2015
• Dynamics of shelterin complex assembly (P205/12/0550), Czech Science Foundation - Standard Grants, 2012 - 2015
• Epigenetic mechanisms of plant telomeres regulation (GAP501/11/0569), Czech Science Foundation - Standard Grants, 2011 - 2015
• Ztráta specifických repetic DNA v důsledku dysfunkce CAF1 u rostlin (GAP501/11/0289), Grantová agentura ČR, 2011 - 2015
• Interakční partneři rostlinných telomer a telomeráz (LH13052), Ministerstvo školství, mládeže a tělovýchovy ČR, 2013 - 2015
• Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci (CZ.1.07/2.3.00/30.0009), Ministerstvo školství, mládeže a tělovýchovy ČR, 2012 - 2015
• MODEXBIO - Rozvoj moderních trendů v experimentální biologii: význam biomolekulárních interakcí pro funkci buněčných struktur (CZ.1.07/2.3.00/30.0019), Ministerstvo školství, mládeže a tělovýchovy ČR, 2012 - 2015
• PlantGPPS - Rozvoj lidských zdrojů pro výzkum, vývoj a inovace v oblasti genomiky a proteomiky rostlinných systémů (CZ.1.07/2.3.00/20.0043), Ministerstvo školství, mládeže a tělovýchovy ČR, 2011 - 2014
• Telomeres and telomerase: transition from molecular to structural biology approach (IAA500040801), Akademie věd ČR, 2008 - 2012
• Molecular basis of cell and tissue regulations (MSM0021622415), Ministerstvo školství, mládeže a tělovýchovy ČR, 2005 - 2011