Prof. Michael Doubek, Ph.D.

Publications that are part of the Web of Science database, possibly also other publications chosen by authors.

2020

• Gokbuget, N; Dombret, H; Giebel, S; Bruggemann, M; Doubek, M; Foa, R; Hoelzer, D; Kim, C; Martinelli, G; Parovichnikova, E; Ribera, JM; Schoonen, M; Tuglus, C; Zugmaier, G; Bassan, R, 2020: Blinatumomab vs historic standard-of-care treatment for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukaemia. EUROPEAN JOURNAL OF HAEMATOLOGY , doi: 10.1111/ejh.13375
• Condoluci, A; di Bergamo, LT; Langerbeins, P; Hoechstetter, MA; Herling, CD; De Paoli, L; Delgado, J; Rabe, KG; Gentile, M; Doubek, M; Mauro, FR; Chiodin, G; Mattsson, M; Bahlo, J; Cutrona, G; Kotaskova, J; Deambrogi, C; Smedby, KE; Spina, V; Bruscaggin, A; Wu, W; Moia, R; Bianchi, E; Gerber, B; Zucca, E; Gillessen, S; Ghielmini, M; Cavalli, F; Stussi, G; Hess, MA; Baumann, TS; Neri, A; Ferrarini, M; Rosenquist, R; Forconi, F; Foa, R; Pospisilova, S; Morabito, F; Stilgenbauer, S; Dohner, H; Parikh, SA; Wierda, WG; Montserrat, E; Gaidano, G; Hallek, M; Rossi, D, 2020: International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia. BLOOD 135(21), p. 1859 - 1869, doi: 10.1182/blood.2019003453

2019

• Doubkova, M; Kozubik, KS; Radova, L; Pesova, M; Trizuljak, J; Pal, K; Svobodova, K; Reblova, K; Svozilova, H; Vrzalova, Z; Pospisilova, S; Doubek, M, 2019: A novel germline mutation of the SFTPA1 gene in familial interstitial pneumonia. HUMAN GENOME VARIATION 6, doi: 10.1038/s41439-019-0044-z
• Baliakas, P; Jeromin, S; Iskas, M; Puiggros, A; Plevova, K; Nguyen-Khac, F; Davis, Z; Rigolin, GM; Visentin, A; Xochelli, A; Delgado, J; Baran-Marszak, F; Stalika, E; Abrisqueta, P; Durechova, K; Papaioannou, G; Eclache, V; Dimou, M; Iliakis, T; Collado, R; Doubek, M; Calasanz, MJ; Ruiz-Xiville, N; Moreno, C; Jarosova, M; Leeksma, AC; Panayiotidis, P; Podgornik, H; Cymbalista, F; Anagnostopoulos, A; Trentin, L; Stavroyianni, N; Davi, F; Ghia, P; Kater, AP; Cuneo, A; Pospisilova, S; Espinet, B; Athanasiadou, A; Oscier, D; Haferlach, C; Stamatopoulos, K, 2019: Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact. BLOOD 133(11), p. 1205 - 1216, doi: 10.1182/blood-2018-09-873083
• Kozubik, KS; Trizuljak, J; Peova, M; Pal, K; Reblova, K; Radova, L; Pospiilova; Doubek, M, 2019: A novel germline mutation in GP1BA gene in family with hereditary macrothrombocytopenia. EUROPEAN JOURNAL OF HUMAN GENETICS 27, p. 208 - 208
• Trizuljak, J; Doubkova, M; Hrazdirova, A; Vrzalova, Z; Blahakova, I; Radova, L; Pospisilova, S; Doubek, M, 2019: A rare diagnosis: Hermansky-Pudlak syndrome in a patient with pulmonary fibrosis, oculocutaneous albinism and thrombocytopathy. EUROPEAN JOURNAL OF HUMAN GENETICS 27, p. 1252 - 1252
• Gorska, A; Gruchala-Niedoszytko, M; Lange, M; Niedoszytko, M; Valent, P; Brockow, K; Gotlib, J; Triggiani, M; Sperr, WR; Elberink, HO; Hartmann, K; Gleixner, KV; Bonifacio, M; Bonadonna, P; Zanotti, R; Arock, M; Hermine, O; Sabato, V; Aberer, E; Van Anrooij, B; Reiter, A; Doubek, M, 2019: Impact of the body mass index in patients with mastocytosis. ALLERGY 74, p. 424 - 425
• Condoluci, A; di Bergamo, LT; Langerbeins, P; Hoechstetter, M; Herling, C; De Paoli, L; Delgado, J; Rabe, KG; Gentile, M; Doubek, M; Mauro, FR; Chiodin, G; Mattsson, M; Bahlo, J; Cutrona, G; Kotaskova, J; Deambrogi, C; Spina, V; Bruscaggin, A; Moia, R; Bianchi, E; Gerber, B; Zucca, E; Ghielmini, M; Cavalli, F; Stussi, G; Neri, A; Ferrarini, M; Rosenquist, R; Forconi, F; Foa, R; Pospisilova, S; Morabito, F; Parikh, SA; Wierda, WG; Montserrat, E; Gaidano, G; Hallek, M; Rossi, D, 2019: International Prognostic Score (IPS-A) for Patients with Early Stage Chronic Lymphocytic Leukemia. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA 19, p. S278 - S278, doi: 10.1016/j.clml.2019.07.212
• Doubkova, M; Trizuljak, J; Vrzalova, Z; Hrazdirova, A; Blahakova, I; Radova, L; Pospisilova, S; Doubek, M, 2019: Novel genetic variant of HPS1 gene in Hermansky-Pudlak syndrome with fulminant progression of pulmonary fibrosis: a case report. BMC PULMONARY MEDICINE 19(1), doi: 10.1186/s12890-019-0941-4
• Jarosov?, M; Plevov?, K; Kotaskov?, J; Doubek, M; Posp?silov?, S, 2019: The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature. LEUKEMIA & LYMPHOMA 60(10), p. 2348 - 2355, doi: 10.1080/10428194.2019.1576038
• Sperr, WR; Kundi, M; Alvarez-Twose, I; van Anrooij, B; Elberink, JNGO; Gorska, A; Niedoszytko, M; Gleixner, KV; Hadzijusufovic, E; Zanotti, R; Bonadonna, P; Bonifacio, M; Perkins, C; Illerhaus, A; Elena, C; Merante, S; Shoumariyeh, K; von Bubnoff, N; Parente, R; Jawhar, M; Fortina, AB; Caroppo, F; Brockow, K; Zink, A; Fuchs, D; Kilbertus, AJ; Yavuz, AS; Doubek, M; Hagglund, H; Panse, J; Sabato, V; Bretterklieber, A; Niederwieser, D; Breynaert, C; Hartmann, K; Triggiani, M; Nedoszytko, B; Reiter, A; Orfao, A; Hermine, O; Gotlib, J; Arock, M; Kluin-Nelemans, HC; Valent, P, 2019: International prognostic scoring system for mastocytosis (IPSM): a retrospective cohort study. LANCET HAEMATOLOGY 6(12), p. E638 - E649, doi: 10.1016/S2352-3026(19)30166-8
• Salles, G; Bachy, E; Smolej, L; Simkovic, M; Baseggio, L; Panovska, A; Besson, H; Healy, N; Garside, J; Iraqi, W; Diels, J; Pick-Lauer, C; Spacek, M; Urbanova, R; Lysak, D; Hermans, R; Lundbom, J; Callet-Bauchu, E; Doubek, M, 2019: Single-agent ibrutinib in RESONATE-2 (TM) and RESONATE (TM) versus treatments in the real-world PHEDRA databases for patients with chronic lymphocytic leukemia. ANNALS OF HEMATOLOGY 98(12), p. 2749 - 2760, doi: 10.1007/s00277-019-03830-8

2018

• Kozubik, KS; Radova, L; Pesova, M; Reblova, K; Trizuljak, J; Plevova, K; Fiamoli, V; Gumulec, J; Urbankova, H; Szotkowski, T; Mayer, J; Pospisilova, S; Doubek, M, 2018: C-terminal RUNX1 mutation in familial platelet disorder with predisposition to myeloid malignancies. INTERNATIONAL JOURNAL OF HEMATOLOGY 108(6), p. 652 - 657, doi: 10.1007/s12185-018-2514-3
• Trizuljak, J; Kozubik, KS; Radova, L; Pesova, M; Pal, K; Reblova, K; Stehlikova, O; Smejkal, P; Zavrelova, J; Pacejka, M; Mayer, J; Pospisilova, S; Doubek, M, 2018: A novel germline mutation in GP1BA gene N-terminal domain in monoallelic Bernard-Soulier syndrome. PLATELETS 29(8), p. 827 - 833, doi: 10.1080/09537104.2018.1529300
• Hrabovsky, S; Folber, F; Horacek, JM; Stehlikova, O; Jelinkova, H; Salek, C; Doubek, M, 2018: Comparison of Real-time Quantitative Polymerase Chain Reaction and Eight-color Flow Cytometry in Assessment of Minimal Residual Disease in Adult Acute Lymphoblastic Leukemia. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA 18(11), p. 743 - 748, doi: 10.1016/j.clml.2018.06.030
• Rawstron, AC; Kreuzer, KA; Soosapilla, A; Spacek, M; Stehlikova, O; Gambell, P; McIver-Brown, N; Villamor, N; Psarra, K; Arroz, M; Milani, R; de la Serna, J; Cedena, MT; Jaksic, O; Nomdedeu, J; Moreno, C; Rigolin, GM; Cuneo, A; Johansen, P; Johnsen, HE; Rosenquist, R; Niemann, CU; Kern, W; Westerman, D; Trneny, M; Mulligan, S; Doubek, M; Pospisilova, S; Hillmen, P; Oscier, D; Hallek, M; Ghia, P; Montserrat, E, 2018: Reproducible diagnosis of chronic lymphocytic leukemia by flow cytometry: An European Research Initiative on CLL (ERIC) & European Society for Clinical Cell Analysis (ESCCA) Harmonisation project. CYTOMETRY PART B-CLINICAL CYTOMETRY 94(1900-01-01T00:00:00.000), p. 121 - 128, doi: 10.1002/cyto.b.21595
• Brazdilova, K; Plevova, K; Francova, HS; Kockova, H; Borsky, M; Bikos, V; Malcikova, J; Oltova, A; Kotaskova, J; Tichy, B; Brychtova, Y; Mayer, J; Doubek, M; Pospisilova, S, 2018: Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL. LEUKEMIA 32(1), p. 234 - 236, doi: 10.1038/leu.2017.274
• Plesingerova, H; Janovska, P; Mishra, A; Smyckova, L; Poppova, L; Libra, A; Plevova, K; Ovesna, P; Radova, L; Doubek, M; Pavlova, S; Pospisilova, S; Bryja, V, 2018: Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia. HAEMATOLOGICA 103(2), p. 313 - 324, doi: 10.3324/haematol.2017.178699
• Kubesova, B; Pavlova, S; Malcikova, J; Kabathova, J; Radova, L; Tom, N; Tichy, B; Plevova, K; Kantorova, B; Fiedorova, K; Slavikova, M; Bystry, V; Kissova, J; Gisslinger, B; Gisslinger, H; Penka, M; Mayer, J; Kralovics, R; Pospisilova, S; Doubek, M, 2018: Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status. LEUKEMIA 32(2), p. 450 - 461, doi: 10.1038/leu.2017.230

2017

• Rabenhorst, A; Sperr, W; Elberink, JO; Lange, M; Gleixner, K; Brazzelli, V; Fontana, E; Vos, B; Gorska, A; Reiter, A; Schwaab, J; Zanotti, R; Bonadonna, P; Triggiani, M; Gotlib, J; Doubek, M; Jakob, T; Kilbertus, A; Sabato, V; Zink, A; Bretterklieber, A; Jaekel, N; Sotlar, K; Zink, A; Fortina, AB; Merante, S; Niedoszytko, M; Kluin-Nelemans, H; Valent, P; Hartmann, K, 2017: Age at disease onset has a major impact on clinical characteristics and course of mastocytosis. EXPERIMENTAL DERMATOLOGY 26(3), p. E6 - E6
• Plesingerova, H; Librova, Z; Plevova, K; Libra, A; Tichy, B; Francova, HS; Vrbacky, F; Smolej, L; Mayer, J; Bryja, V; Doubek, M; Pospisilova, S, 2017: COBLL1, LPL and ZAP70 expression defines prognostic subgroups of chronic lymphocytic leukemia patients with high accuracy and correlates with IGHV mutational status. LEUKEMIA & LYMPHOMA 58(1), p. 70 - 79, doi: 10.1080/10428194.2016.1180690
• Ledererova, A; Kozlova, V; Vakulova, V; Doubek, M; Mayer, J; Pospisilova, S; Smida, M, 2017: B CELLS RESISTANT TO CD20 MONOCLONAL ANTIBODIES DISPLAY SPECIFIC ALTERATIONS IN GENE EXPRESSION PROFILE. HAEMATOLOGICA 102, p. 709 - 709
• Pavlasova, G; Borsky, M; Svobodova, V; Musilova, K; Cerna, K; Seda, V; Osickova, J; Brychtova, Y; Doubek, M; Pospisilova, S; Mayer, J; Mraz, M, 2017: BCR SIGNALLING PROFICIENT CHRONIC LYMPHOCYTIC LEUKAEMIA B CELLS ARE PRONE TO RITUXIMAB MEDIATED ELIMINATION IN VIVO. HAEMATOLOGICA 102, p. 412 - 412
• Plevova, K; Malcikova, J; Pavlova, S; Kotaskova, J; Poppova, L; Smardova, J; Diviskova, E; Durechova, K; Oltova, A; Brychtova, Y; Panovska, A; Doubek, M; Pospisilova, S, 2017: BIALLELIC TP53 GENE MUTATIONS DUE TO COPY-NEUTRAL LOSS OF HETEROZYGOSITY AND MONOALLELIC MUTATIONS IN ABSENCE OF 17P DELETION OCCUR IN CLL WITH COMPARABLE FREQUENCY. HAEMATOLOGICA 102, p. 65 - 66
• Hrabovsky, S; Folber, F; Horacek, J; Stehlikova, O; Jelinkova, H; Salek, C; Doubek, M, 2017: COMPARISON OF 8-COLOR FLOW CYTOMETRY AND PCR-BASED METHODS IN MEASUREMENT OF MINIMAL RESIDUAL DISEASE IN ADULT ACUTE LYMPHOBLASTIC LEUKEMIA. HAEMATOLOGICA 102, p. 347 - 347
• Baliakas, P; Jeromin, S; Iskas, M; Puiggros, A; Plevova, K; Xochelli, A; Delgado, J; Kotaskova, J; Stalika, E; Abrisqueta, P; Durechova, K; Papaioannou, G; Collado, R; Doubek, M; Calasanz, MJ; Ruiz-Xiville, N; Moreno, C; Leeksma, AC; Anagnostopoulos, A; Ghia, P; Stavroyianni, N; Kater, AP; Espinet, B; Pospisilova, S; Athanasiadou, A; Stamatopoulos, K; Haferlach, C, 2017: CYTOGENETIC COMPLEXITY IN CHRONIC LYMPHOCYTIC LEUKEMIA: DEFINITIONS, ASSOCIATIONS WITH OTHER BIOMARKERS AND CLINICAL IMPACT; A RETROSPECTIVE STUDY ON BEHALF OF ERIC. HAEMATOLOGICA 102, p. 170 - 170
• Kotaskova, J; Pavlova, S; Plevova, K; Malcikova, J; Stehlikova, O; Poppova, L; Kockova, H; Doubek, M; Bryja, V; Pospisilova, S, 2017: TREATMENT WITH BCR INHIBITORS INCREASES ROR1 EXPRESSION IN CLL CELLS. HAEMATOLOGICA 102, p. 414 - 414

2016

• Poppova, L; Janovska, P; Plevova, K; Radova, L; Plesingerova, H; Borsky, M; Kotaskova, J; Kantorova, B; Hlozkova, M; Figulova, J; Brychtova, Y; Doubek, M; Kozubik, A; Pospisilova, S; Pavlova, S; Bryja, V, 2016: DECREASED EXPRESSION OF WNT3, A CANONICAL WNT PATHWAY LIGAND, IS FREQUENT IN CHRONIC LYMPHOCYTIC LEUKEMIA PROGRESSION AND IDENTIFIES PATIENTS WITH SHORT TREATMENT-FREE SURVIVAL IN MUTATED IGHV SUBSET. HAEMATOLOGICA 101, p. 423 - 424
• Kubesova, B; Pavlova, S; Malcikova, J; Kabathova, J; Radova, L; Tom, N; Tichy, B; Plevova, K; Kantorova, B; Fiedorova, K; Kissova, J; Gisslinger, B; Gisslinger, H; Mayer, J; Kralovics, R; Pospisilova, S; Doubek, M, 2016: Low-Burden TP53 Mutations Occur in Chronic Phase of Myeloproliferative Neoplasms Regardless of Hydroxyurea Administration, Disease Type, and JAK2 Status. BLOOD 128(22)
• Doubkova, M; Karpisek, M; Mazoch, J; Skrickova, J; Doubek, M, 2016: PROGNOSTIC SIGNIFICANCE OF SURFACTANT PROTEIN A, SURFACTANT PROTEIN D, CLARA CELL PROTEIN 16, S100 PROTEIN, TREFOIL FACTOR 3, AND PROSTATIC SECRETORY PROTEIN 94 IN IDIOPATHIC PULMONARY FIBROSIS, SARCOIDOSIS, AND CHRONIC PULMONARY OBSTRUCTIVE DISEASE. SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES 33(3), p. 224 - 234

• Vyhledávání a funkční testování variant genů predisponujících k familiárním onemocněním krvetvorby, , 2020 - 2023
• Expression and function of activation-induced cytidine deaminase splice variants in normal B cell physiology and chronic lymphocytic leukemia (3SGA5792), Jihomoravský kraj, 2013 - 2016
• Functional and structural changes of microRNAs in lymphoproliferative malignancies and their impact on prognosis and prediction of therapy response (NT11218), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2010 - 2015
• NGS-PTL - Next Generation Sequencing platform for targeted Personalized Therapy of Leukemia (306242), Evropská unie, 2012 - 2015
• SuPReMMe - Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny (CZ.1.07/2.3.00/20.0045), Ministerstvo školství, mládeže a tělovýchovy ČR, 2011 - 2014
• Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies (MSM0021622430), Ministerstvo školství, mládeže a tělovýchovy ČR, 2007 - 2013
• Real-time PCR soupravy pro diagnostiku v onkologii (FR-TI2/254), Ministerstvo průmyslu a obchodu ČR, 2010 - 2013
• Involvement of nuclear HMGB proteins in sensitizing of human cells to anticancer drugs inhibiting DNA topoizomerases (GAP301/10/0590), Czech Science Foundation - Standard Grants, 2010 - 2012
• Analysis of changes in genome and its expression in chronic lymphocytic leukemia patients during the disease development (NS10439), Ministry of Health - Departmental Programme of Research and Development (2008-2011), 2009 - 2011