Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment

MOLECULAR CANCER

Sternberg, C; Raigel, M; Limberger, T; Trachtová, K; Schlederer, M; Lindner, D; Kodajova, P; Yang, JY; Ziegler, R; Kalla, J; Stoiber, S; Dey, S; Zwolanek, D; Neubauer, HA; Oberhuber, M; Redmer, T; Hejret, V; Tichy, B; Tomberger, M; Harbusch, NS; Pencik, J; Tangermann, S; Bystry, V; Persson, JL; Egger, G; Pospisilova, S; Eferl, R; Wolf, P; Sternberg, F; Högler, S; Lagger, S; Rose-John, S; Kenner, L, 2024: Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment. MOLECULAR CANCER 23(1), doi: 10.1186/s12943-024-02114-8

Research Groups:

Bioinformatics Core Facility
Medical Genomics
Molecular Oncology - Solid Cancer

CEITEC authors:

Karolína Trachtová
Václav Hejret
Boris Tichý, Ph.D.
Vojtěch Bystrý, Ph.D.
Prof. Šárka Pospíšilová, Ph.D.