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If you would like to participate online, please contact us at events@ceitec.muni.cz. Online participation is not possible on a one-time basis. It is intended for students whose health and other conditions prevent them from attending on-site during the semester.
Endocytosis is a highly dynamic process that determines the composition of the plasma membrane (PM). The dysfunction of endocytic pathways is a causal factor behind a number of human genetic diseases, and its dys-regulation can contribute to neurodegeneration. Despite the critical role that endocytosis plays in health and disease, surprisingly little is known about how it is regulated. A major potential regulation point is the dynamic phosphorylation of endocytic components by kinases. However, it is poorly understood which kinases (and phosphatases) control endocytosis and the PM proteome, even though they represent potential targets for disease-modifying therapies. My long-term vision is to understand the integration of protein kinases within membrane-trafficking machinery with a starting focus is on the Numb-associated kinase family (NAK). NAKs were identified as a susceptibility factor in Parkinson’s disease and neuropathic pain but the molecular mechanisms behind this are not clear.
In this talk will elucidate the key cellular functions of NAKs: (1) which cellular processes and substrates are associated with NAKs (2) the consequences of their activity for cellular physiology.
