Contact
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| Phone: | +420 54949 7756 |
| Research group: | Structural Virology - Pavel Plevka |
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Pavel Plevka is research group leader at Central European Institute of Technology, Masaryk University. He obtained his MSc. degree in molecular biology and virology from Charles University and his Ph.D. in structural biology from Uppsala University in 2009. From 2009 till 2013 he was a post-doctoral fellow with Michael Rossmann at Purdue University. In 2013 he established the group of Structural Virology at CEITEC, Masaryk University.
Plevka has determined structures of several viruses, most notably that of human enterovirus 71 that causes potentially fatal encephalitis in small children. Furthermore, he studied maturation of dengue virus. He focuses on X-ray crystallography and cryo-electron microscopy of viruses and other macromolecular complexes.
2. Dec. 2019
Jak zničit zlatého stafylokoka, který odolá i antibiotikům? Nemocným dává naději fág P68
Vědecký tým pod vedením Dominika Hrebíka z brněnského institutu CEITEC dokázal popsat vlastnosti bakteriofágu, který si dokáže bez problémů…
25. Nov. 2019
Bacteriophages Could Help Against Antibiotic Resistance
Dominik Hrebik, in collaboration with his colleagues from CEITEC Masaryk University, described the structure of the phage P68, known for its ability…
30. May 2019
Virologists Discovered a New Mechanism for Penetration of Viruses into Cells
A number of diseases, from a common cold to encephalitis or poliomyelitis, are caused by enteroviruses. To proliferate, viruses have to deliver…
14. May 2019
International media El País and La Repubblica reported on CEITEC MU: Leading Research Institute Draws Scientific Talent to the Czech Republic
CEITEC Masaryk University scientific talents attract media across Europe - El País and La Repubblica. European funds have…
4. Mar. 2019
Report of Czech Television with Pavel Plevka: Virus in Nitrogen
The article is only in Czech.
26. June 2018
Pavel Plevka for TÉMA magazine: Virus. Enemy and friend.
Pavel Plevka, a virologist from CEITEC MU, provided an interview for TÉMA magazine. Pavel Plevka's research could be a basis for the treatment of…
5. Feb. 2018
Pavel Plevka’s Team From CEITEC MU Discovered How an Antibody Neutralizes the Tick-borne Encephalitis Virus
Press release, Brno, 2 February 2018 The Czech Republic belongs among the countries with the highest presence of tick-borne encephalitis virus in…
27. Feb. 2017
"Je to ohromně nefér." Čeští vědci reagují na Trumpův protimuslimský dekret, kolegům nabízejí práci (Aktuálně.cz)
2019
- Buchta, D; Füzik, T; Hrebík, D; Levdansky, Y; Sukeník, L; Mukhamedova, L; Moravcová, J; Vácha, R; Plevka, P., 2019: Enterovirus particles expel capsid pentamers to enable genome release. NATURE COMMUNICATIONS , doi: 10.1038/s41467-019-09132-x
2018
- Füzik, T; Formanová, P; Růžek, D; Yoshii, K; Niedrig, M; Plevka, P., 2018: Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody. NATURE COMMUNICATIONS , doi: 10.1038/s41467-018-02882-0
- Grybchuk, D; Akopyants, NS; Kostygov, AY; Konovalovas, A; Lye, LF; Dobson, DE; Zangger, H; Fasel, N; Butenko, A; Frolov, AO; Votypka, J; d´Avila-Levy, CM; Kulich, P; Moravcova, J; Plevka, P; Rogozin, IB; Serva, S; Lukes, J; Beverley, SM; Yurchenko, V, 2018: Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115(3), p. E506 - E515, doi: 10.1073/pnas.1717806115
- Prochazkova, M; Fuzik, T; Skubnik, K; Moravcova, J; Ubiparip, Z; Pridal, A; Plevka, P, 2018: Virion structure and genome delivery mechanism of sacbrood honeybee virus. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115(30), p. 7759 - 7764, doi: 10.1073/pnas.1722018115
2017
- Jasnovidova, O; Klumpler, T; Kubicek, K; Kalynych, S; Plevka, P; Stefl, R, 2017: Structure and dynamics of the RNAPII CTDsome with Rtt103. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114(42), p. 11133 - 11138, doi: 10.1073/pnas.1712450114
- Kalynych, S.; Fuzik, T.; Pridal, A.; de Miranda, J.; Plevka, P., 2017: Cryo-EM study of slow bee paralysis virus at low pH reveals iflavirus genome release mechanism. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 3(114), p. 598 - 603, doi: 10.1073/pnas.1616562114
- Spurny, R; Pridal, A; Palkove, L; Tran Kiem, H. K; de Miranda, J R; Plevka,, 2017: Virion structure of black queen cell virus, a common honeybee pathogen. JOURNAL OF VIROLOGY , doi: 10.1128/JVI.02100-16
- Mullapudi, E; Fuzik, T; Pridal, A; Plevka, P, 2017: Cryo-electron Microscopy Study of the Genome Release of the Dicistrovirus Israeli Acute Bee Paralysis Virus. JOURNAL OF VIROLOGY 91(4), doi: 10.1128/jvi.02060-16
- Zeman, M; Maslanova, I; Indrakova, A; Siborova, M; Mikulasek, K; Bendickova, K; Plevka, P; Vrbovska, V; Zdrahal, Z; Doskar, J; Pantucek, R, 2017: Staphylococcus sciuri bacteriophages double-convert for staphylokinase and phospholipase, mediate interspecies plasmid transduction, and package mecA gene. SCIENTIFIC REPORTS 7, doi: 10.1038/srep46319
- Skubnik, K; Novacek, J; Fuzik, T; Pridal, A; Paxton, RJ; Plevka, P, 2017: Structure of deformed wing virus, a major honey bee pathogen. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114(12), p. 3210 - 3215, doi: 10.1073/pnas.1615695114
2016
- Sabin, C; Plevka, P, 2016: The use of noncrystallographic symmetry averaging to solve structures from data affected by perfect hemihedral twinning. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 72, p. 188 - 197, doi: 10.1107/S2053230X16000923
- Kalynych S; Přidal A; Pálková L; Levdansky Y; de Miranda JR; Plevka P, 2016: Virion structure of iflavirus slow bee paralysis virus at 2.6Å resolution. JOURNAL OF VIROLOGY 90(16), p. 7444 - 7455
- Mullapudi E; Nováček J; Pálková L; Kulich P; Lindberg AM; van Kuppeveld FJ; Plevka P, 2016: Structure and genome release mechanism of human cardiovirus Saffold virus-3. JOURNAL OF VIROLOGY , p. [Epub ahead of print] -
- Mullapudi E; Přidal A; Pálková L; de Miranda JR; Plevka P, 2016: Virion structure of Israeli acute bee paralysis virus. JOURNAL OF VIROLOGY 90(18), p. 8150 - 8159, doi: 10.1128/JVI.00854-16
- Nováček J; Šiborová M; Benešík M; Pantůček R; Doškař J; Plevka P, 2016: Structure and genome release of Twort-like Myoviridae phage with a double-layered baseplate. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113(33), p. 9351 - 6, doi: 10.1073/pnas.1605883113
- Sabin, C; Fuzik, T; Skubnik, K; Palkova, L; Lindberg, AM; Plevka, P, 2016: Structure of Aichi Virus 1 and Its Empty Particle: Clues to Kobuvirus Genome Release Mechanism. JOURNAL OF VIROLOGY 90(23), p. 10800 - 10810, doi: 10.1128/JVI.01601-16
- Kalynych, S; Palkova, L; Plevka, P, 2016: The Structure of Human Parechovirus 1 Reveals an Association of the RNA Genome with the Capsid. JOURNAL OF VIROLOGY 90(3), p. 1377 - 1386, doi: 10.1128/JVI.02346-15
- Mullapudi, E; Novacek, J; Palkova, L; Kulich, P; Lindberg, AM; van Kuppeveld, FJM; Plevka, P, 2016: Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3. JOURNAL OF VIROLOGY 90(17), p. 7628 - 7639, doi: 10.1128/JVI.00746-16
- Kalynych, S; Pridal, A; Palkova, L; Levdansky, Y; de Miranda, JR; Plevka, P, 2016: Virion Structure of Iflavirus Slow Bee Paralysis Virus at 2.6-Angstrom Resolution. JOURNAL OF VIROLOGY 90(16), p. 7444 - 7455, doi: 10.1128/JVI.00680-16
2013
- Plevka, P; Perera, R; Yap, ML; Cardosa, J; Kuhn, RJ; Rossmann, MG, 2013: Structure of human enterovirus 71 in complex with a capsid-binding inhibitor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110(14), p. 5463 - 5467, doi: 10.1073/pnas.1222379110
- Zhang, XZ; Sheng, J; Plevka, P; Kuhn, RJ; Diamond, MS; Rossmann, MG, 2013: Dengue structure differs at the temperatures of its human and mosquito hosts. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110(17), p. 6795 - 6799, doi: 10.1073/pnas.1304300110
- Meng, G; Zhang, XZ; Plevka, P; Yu, Q; Tijssen, P; Rossmann, MG, 2013: The Structure and Host Entry of an Invertebrate Parvovirus. JOURNAL OF VIROLOGY 87(23), p. 12523 - 12530, doi: 10.1128/JVI.01822-13
- Prasad, VM; Willows, SD; Fokine, A; Battisti, AJ; Sun, SY; Plevka, P; Hobman, TC; Rossmann, MG, 2013: Rubella virus capsid protein structure and its role in virus assembly and infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110(50), p. 20105 - 20110, doi: 10.1073/pnas.1316681110
- Wang, ZQ; Li, L; Pennington, JG; Sheng, J; Yap, ML; Plevka, P; Meng, G; Sun, L; Jiang, W; Rossmann, MG, 2013: Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody. JOURNAL OF VIROLOGY 87(16), p. 8909 - 8915, doi: 10.1128/JVI.00472-13
2012
- Plevka P., Perera R., Cardosa J., Kuhn R. J., 2012: Crystal Structure of the Hand, Foot, and Mouth Disease Virus, Enterovirus 71. SCIENCE , p. 1274 -
- Battisti, AJ; Meng, G; Winkler, DC; McGinnes, LW; Plevka, P; Steven, AC; Morrison, TG; Rossmann, MG, 2012: Structure and assembly of a paramyxovirus matrix protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109(35), p. 13996 - 14000, doi: 10.1073/pnas.1210275109
- Battisti, AJ; Yoder, JD; Plevka, P; Winkler, DC; Prasad, VM; Kuhn, RJ; Frey, TK; Steven, AC; Rossmann, MG, 2012: Cryo-Electron Tomography of Rubella Virus. JOURNAL OF VIROLOGY 86(20), p. 11078 - 11085, doi: 10.1128/JVI.01390-12
- Plevka, P; Perera, R; Cardosa, J; Kuhn, RJ; Rossmann, MG, 2012: Crystal Structure of Human Enterovirus 71. SCIENCE 336(6086), p. 1274 - 1274, doi: 10.1126/science.1218713
- Plevka, P; Battisti, AJ; Winkler, DC; Tars, K; Holdaway, HA; Bator, CM; Rossmann, MG, 2012: Sample Preparation Induced Artifacts in Cryo-Electron Tomographs. MICROSCOPY AND MICROANALYSIS 18(5), p. 1043 - 1048, doi: 10.1017/S1431927612001298
- Plevka, P; Perera, R; Cardosa, J; Kuhn, RJ; Rossmann, MG, 2012: Structure determination of enterovirus 71. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 68, p. 1217 - 1222, doi: 10.1107/S0907444912025772
2011
- Plevka, P; Battisti, AJ; Junjhon, J; Winkler, DC; Holdaway, HA; Keelapang, P; Sittisombut, N; Kuhn, RJ; Steven, AC; Rossmann, MG, 2011: Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres. EMBO REPORTS 12(6), p. 602 - 606, doi: 10.1038/embor.2011.75
- Plevka, P; Kaufmann, B; Rossmann, MG, 2011: Analysis of phases in the structure determination of an icosahedral virus. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 67, p. 568 - 577, doi: 10.1107/S090744491101448X
- Plevka, P; Hafenstein, S; Li, L; D´Abramo, A; Cotmore, SF; Rossmann, MG; Tattersall, P, 2011: Structure of a Packaging-Defective Mutant of Minute Virus of Mice Indicates that the Genome Is Packaged via a Pore at a 5-Fold Axis. JOURNAL OF VIROLOGY 85(10), p. 4822 - 4827, doi: 10.1128/JVI.02598-10
- Kaufmann, B; El-Far, M; Plevka, P; Bowman, VD; Li, Y; Tijssen, P; Rossmann, MG, 2011: Structure of Bombyx mori Densovirus 1, a Silkworm Pathogen. JOURNAL OF VIROLOGY 85(10), p. 4691 - 4697, doi: 10.1128/JVI.02688-10
- Rossmann, MG; Battisti, AJ; Plevka, P, 2011: FUTURE PROSPECTS. ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY, VOL 82: RECENT ADVANCES IN ELECTRON CRYOMICROSCOPY, PT B 82, p. 101 - 121, doi: 10.1016/B978-0-12-386507-6.00005-1
2010
- Kaufmann, B; Plevka, P; Kuhn, RJ; Rossmann, MG, 2010: Crystallization and preliminary X-ray diffraction analysis of West Nile virus. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 66, p. 558 - 562, doi: 10.1107/S1744309110009899
- Plevka, P; Hafenstein, S; Harris, KG; Cifuente, JO; Zhang, Y; Bowman, VD; Chipman, PR; Bator, CM; Lin, F; Medof, ME; Rossmann, MG, 2010: Interaction of Decay-Accelerating Factor with Echovirus 7. JOURNAL OF VIROLOGY 84(24), p. 12665 - 12674, doi: 10.1128/JVI.00837-10
2009
- Plevka P, Kazaks A, Voronkova T, Kotelovica S, Dishlers A, Liljas L, Tars K, 2009: The structure of bacteriophage phi Cb5 reveals a role of the RNA genome and metal ions in particle stability and assembly. JOURNAL OF MOLECULAR BIOLOGY 391(3), p. 635 - 647
- Replikace fágů v bakteriálním biofilmu, , 2020 - 2024
- Structural study of enterovirus replication in situ, Grantová agentura ČR, 2019 - 2023
- In vivo strukturní analýza replikace fága infikujícího zlatého stafylokoka (GA18-17810S), Grantová agentura ČR, 2018 - 2020
- Structure and DNA delivery mechanism of gene transfer agent, Masarykova univerzita, 2019 - 2020
- Structural studies of human and animal pathogens from the order Picornavirales (3041), EMBO (European Molecular Biology Organization), 2015 - 2019
- Structural studies of flaviviruses and their neutralization by antibodies (GA17-02196S), Grantová agentura ČR, 2017 - 2019
- Czech Infrastructure for Integrative Structural Biology (LM2015043), Ministerstvo školství, mládeže a tělovýchovy ČR, 2016 - 2019
- Structural studies of human picornaviruses directed towards development of anti-viral compounds (335855), Evropská unie, 2014 - 2019
- Příprava mezinárodního projektu MSCA ITN ´ViralDetectives´ zaměřeného na studium RNA virů (MUNI/F/0019/2018), Masarykova univerzita, 2018 - 2018
- Structural studies of human and animal pathogens from the order Picornavirales, EMBO (European Molecular Biology Organization ) grants, 2015 - 2017
- Strukturní studie potenciálního protibakteriálního agens, fága 812K1-420 infikujícího zlatého stafylokoka (GA15-21631Y), Grantová agentura ČR, 2015 - 2017
- Structural biology methods (MUNI/FR/1676/2014), Masarykova univerzita, 2015 - 2015
- CEITEC - Central European Institute of Technology (CZ.1.05/1.1.00/02.0068), Ministerstvo školství, mládeže a tělovýchovy ČR, 2011 - 2015
- Zavedení předmětu Strukturní virologie do výuky na oboru Speciální biologie, směr Mikrobiologie a molekulární biotechnologie (MUNI/FR/0109/2014), Masarykova univerzita, 2014 - 2014