Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation

MOLECULAR CANCER THERAPEUTICS

Samadder, P; Suchankova, T; Hylse, O; Khirsariya, P; Nikulenkov, F; Drapela, S; Strakova, N; Vanhara, P; Vasickova, K; Kolarova, H; Bino, L; Bittova, M; Ovesna, P; Kollar, P; Fedr, R; Esner, M; Jaros, J; Hampl, A; Krejci, L; Paruch, K; Soucek, K, 2017: Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation. MOLECULAR CANCER THERAPEUTICS 16(9), p. 1831 - 1842, doi: 10.1158/1535-7163.MCT-17-0018

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