RNA Quality Control

ABOUT US

RNA Quality Control

RNA is not simply an intermediary between DNA and proteins. It is involved in a wide range of processes that are essential for cell survival. To ensure that everything functions correctly, RNA must be modified and checked after it is produced, and removed if it is defective. RNA quality control is therefore an important mechanism that protects cells from the accumulation of damaged or non-functional molecules.

Projects

Grantová agentura ČR

Tackling the role of m6A RNA demethylase in mRNA biogenesis

2026 - 2028

Grantová agentura ČR

Identification and role of proteins in control and degradation of RNA and regulation of…

2023 - 2025

Grantová agentura ČR

System analysis of functional interactions of human RNA demethylases

2022 - 2024

Grantová agentura ČR

Molecular mechanisms and evolution of RNA polyadenylation in euglenophyte plastids

2021 - 2023

Our Publications

PROTEIN SCIENCE

Staufen-swapping motif is crucial for Staufen dimerization, structure, and Staufen-mediated mRNA decay

Tripepi, A; Shakoor, H; Zlobina, M; Klumpler, T; Kubícková, M; Houser, J; Klapetek, P; Lukavsky, PJ

doi: 10.1002/pro.70669

RNA

Global analysis by LC-MS/MS of N6-methyladenosine and inosine in mRNA reveal complex incidence

Stejskal, S; Rájecká, V; Covelo-Molares, H; Sinigaglia, K; Brozinová, K; Kasiarová, L; Dohnálková, M; Reyes-Gutierrez, PE; Cahová, H; Keegan, LP; O'Connell, MA; Vanácová, S

doi: 10.1261/rna.080324.124

MOLECULAR CELL

m6A sites in the coding region trigger translation-dependent mRNA decay

Zhou, Y; Corovic, M; Hoch-Kraft, P; Meiser, N; Mesitov, M; Körtel, N; Back, H; Naarmann-de Vries, IS; Katti, K; Obrdlík, A; Busch, A; Dieterich, C; Vanácová, S; Hengesbach, M; Zarnack, K; König, J

doi: 10.1016/j.molcel.2024.10.033

SCIENTIFIC REPORTS