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Frascan II: methods and applications

Supervisor Pavel Kadeřávek, Ph.D.
Research Group Magneto-optical & THz spectroscopy (Petr Neugebauer) together with Dadok National NMR Center

One of the largest issues nowadays is efficient magnetic resonance spectroscopy, including NMR spectroscopy. This postdoctoral project focuses on the optimization and applications of the newly developed FRASCAN II spectrometer, which currently enables liquid high-field 1H, 13C, 31P,… NMR, 329 GHz ESR, and DNP. The candidate will focus on:

  • NMR and DNP experiments of biomolecules
  • implement and troubleshoot methodology for a frequency-swept and rapid scan ESR of radicals in liquids.
  • Seek potential applications of the developed methodology and its modification to other areas of chemical research – environmental studies, semiconductor industry,…
  • Closely collaborate with CEITEC MUNI and other CEITEC group partners.
See list of topics
  1. Assembly and maturation of flaviviruses
  2. Cell entry and genome delivery of non-enveloped viruses
  3. Design principles of fusogenic proteins for lipid vesicles
  4. Development of advanced MRI techniques for functional brain mapping
  5. Frascan II: methods and applications
  6. How whole-genome triplication shaped desert adaptation in Brassiceae
  7. Integrating osteological and biomolecular evidence to investigate chromosomal aneuploidies in past populations
  8. Lipid nanoparticles in drug delivery
  9. Method development in palaeoproteomics
  10. Next-generation anticancer therapies based on metallodrugs
  11. One protein to rule them all: Decoding the multifunctionality of paramyxovirus matrix proteins
  12. Pushing the frontiers of magnetic resonance spectroscopy for biotechnology and materials engineering
  13. Regulation of drought stress memory and resilience in Brassica napus plants
  14. Retrogene evolution in Brassicaceae: The roles of genomic context and polyploid history
  15. RNA-associated mechanisms in Polycomb-mediated epigenetic silencing
  16. Tracing brain disease back to developmental decisions
  17. Translation Control